Keystone eSymposia Logo

Joint meeting with NeuroImmune Interactions in Health and Disease

Neurodegenerative Diseases: Genes, Mechanisms and Therapeutics

June 7-9, 2021 | 9:00AM EDT | 1:00PM UTC | 3:00PM CEST*
*Program is in development and subject to change


The live portion of this conference has concluded and all presentations are now available for purchase on demand. Registrants to the live event may access this content anytime for up to 9 months following the event.

 Free Access to On Demand Content to Scientists from Low-and Middle-Income Countries

Keystone Symposia welcomes the global scientific community and aims to connect researchers within and across disciplines to accelerate the advancement of biomedical and life sciences. This form may be used for scientists from low- and middle-income countries of all career stages to determine eligibility and request free access to scientific content presented during recent eSymposia events. If eligible, you will be sent an access code for the On Demand content of the eSymposia event(s) of interest.

Apply Here

Neurodegenerative diseases, such as Alzheimer’s disease (AD) and AD-related disorders (ADRD) are quickly becoming a global burden. The number of diagnosed cases of neurodegenerative diseases is staggering and rising at an alarming rate as the population ages. While it is well-recognized that neurodegenerative diseases are characterized by aberrant protein misfolding and aggregate formation, the mechanisms that initiate or promote proteinopathy in disease-specific neural circuits remain poorly understood. Recent advances in human genetics and genome-wide association study (GWAS) have uncovered several genetic loci that are critical for the pathogenesis of neurodegenerative diseases. Furthermore, technological advances in transcriptomics, proteomics, and metabolomics offer many critical new insights into the disease mechanism, as well as opportunities for the development of novel therapeutics that can reverse or mitigate neurodegeneration. Despite these exciting new developments, there are significant gaps in connecting genetic information with disease mechanism and in harnessing the critical role of glia-neuron interactions to develop therapeutic interventions. 

This conference aims to provide an integrated discussion of the latest advances in research and therapeutic development for neurodegenerative diseases. This conference program will focus on the roles of genetic risk factors and their contributions to glial and neuronal health in the aging brain, the biophysical properties of protein misfolding and the propagation of disease-specific proteinopathy, the role of intracellular vesicular trafficking in disease pathogenesis, new insights into the diverse role of glia, innate immunity and microbiomes in neurodegeneration, and novel therapeutic approaches that specifically target each of the novel biological areas. It is anticipated that this conference will stimulate more discussions and promote new collaborations among scientists in the academia and industry that ultimately lead to new therapeutic targets to combat neurodegenerative diseases.

Apply Here for Free On Demand Access


Regular Registration Rate: $275 USD
Student Registration Rate: $150 USD


Abstract Submission
‣ For Short Talk Consideration: Passed
‣ For ePoster Presentation: Passed
Final ePoster / SciTalk Submission: Passed
Financial Aid Application: Passed

*Abstract submission is required in order to submit an ePoster and/or Scitalk


Program Details

Keynote Speakers


Christopher K. Glass, MD, PhD
University of California, San Diego


Akiko Iwasaki, PhD
HHMI/Yale University School of Medicine

Speaking at this eSymposia

Mathew M. Blurton-Jones

University of California, Irvine, USA

Anne Brunet

Stanford University, USA

Beverly L. Davidson

Children’s Hospital of Philadelphia and University of Pennsylvania, USA

Valina L. Dawson

Johns Hopkins University School of Medicine, USA

Philip L. De Jager

Columbia University Medical Center, USA

Ádám Dénes

Hungarian Academy of Sciences, Hungary

Fred H. Gage

The Salk Institute for Biological Studies, USA

Christopher K. Glass

University of California, San Diego, USA

Alison Goate

Icahn School of Medicine at Mount Sinai, USA

Michael T. Heneka

German Center for Neurodegenerative Diseases, Germany

Akiko Iwasaki

HHMI/Yale University School of Medicine, USA

Holly Kordasiewicz

Ionis Pharmaceuticals, USA

Virginia M. Y. Lee

University of Pennsylvania School of Medicine, USA

Joseph W. Lewcock

Denali Therapeutics, USA

Johan Luthman

Lundbeck, Denmark

Marco Prinz

University of Freiburg, Germany

Anne Schaefer

Mount Sinai School of Medicine, USA

Sjors Scheres

MRC Laboratory of Molecular Biology, UK

Lorenz Studer

Memorial Sloan Kettering Cancer Center, USA

Charlotte J. Sumner

Johns Hopkins School of Medicine, USA

J. Paul Taylor

St. Jude Children's Research Hospital, USA

Hui-Hsin Tsai

Biogen, USA

Li-Huei Tsai

Massachusetts Institute of Technology, USA

Jennifer Yokoyama

University of California, San Francisco, USA







Additional Support




Funding for this conference was made possible (in part) by 1R13AG072818-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Media-in-Kind Support









The views expressed in this eSymposia are those of the participants and not necessarily of the participants’ organizations or of Keystone Symposia.


This new virtual meeting format came out of difficult circumstances, but your commitment to scientific progress is what inspired us to launch Keystone eSymposia. In these virtual meetings, we are capturing the same innovative essence of our in-person meetings that you've all created as a scientific community.  Here, Debbie Johnson, our CEO, explains how we're going to do that.

Donate to Keystone Symposia

Donate to Keystone Symposia