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Joint meeting with NeuroImmune Interactions in Health and Disease

Neurodegenerative Diseases: Genes, Mechanisms and Therapeutics

June 7-9, 2021 | 9:00AM EDT | 1:00PM UTC | 3:00PM CEST*
*Program is in development and subject to change



Joint Meetings

Your registration provides you with access to both the “Neurodegenerative Diseases: Genes, Mechanisms and Therapeutics” and “NeuroImmune Interactions in Health and Disease” eSymposia events. Use the link below to explore the joint meeting features, including live plenary sessions, On Demand talks, posters, forums, job postings, 1:1 Connect appointments and more. This joint meeting access is designed to facilitate cross-disciplinary insights and collaborations to drive both fields in exciting new directions!

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[Joint Session] Welcoming Remarks and Keynote Address
09:00am - 10:10am Eastern - June 7, 2021
Eric J. Huang, MD, PhD, Co-Chair, University of California, San Francisco; Beth Stevens, PhD, Co-Chair, Boston Children's Hospital, Harvard Medical School
Track: [Joint Session] Welcoming Remarks and Keynote Address

Monday
Manipulating Immune Trafficking In and Out of the CNS
09:00am - 09:40am Eastern - June 7, 2021
Akiko Iwasaki, PhD, Yale University School of Medicine
Track: [Joint Session] Welcoming Remarks and Keynote Address

Monday
Exploiting Dynamic Enhancer Landscapes to Infer Pathogenic Mechanisms in Neurodegenerative Diseases
09:40am - 10:10am Eastern - June 7, 2021
Christopher K. Glass, MD, PhD, University of California, San Diego
Track: [Joint Session] Welcoming Remarks and Keynote Address

[Joint Session] Disease Mechanisms and Therapeutic Targets
10:10am - 01:00pm Eastern - June 7, 2021
Joseph W. Lewcock, PhD, Co-Chair, Denali Therapeutics; Kate Monroe, PhD, Co-Chair, Denali Therapeutics
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Antisense Oligonucleotides for the Treatment of Neurological Diseases
10:10am - 10:35am Eastern - June 7, 2021 | Room: V300 - Ian
Holly Kordasiewicz, PhD, Ionis Pharmaceuticals
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Therapeutic Strategies for the Treatment of Neurodegenerative Disease Based on Human Genetics
10:35am - 11:00am Eastern - June 7, 2021 | Room: V300 - Ian
Joseph W. Lewcock, PhD, Denali Therapeutics
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Enhancing Microglia Function with ATV:TREM2
11:00am - 11:25am Eastern - June 7, 2021 | Room: V300 - Ian
Kate Monroe, PhD, Denali Therapeutics
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Neuroimmunological Target Considerations - To Be or Not To Be in the Brain
11:50am - 12:15pm Eastern - June 7, 2021
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Short Talk: TREM2-Independent Neuroprotection Mediated by Monocyte-Derived Macrophages in a Mouse Model of Alzheimer’s Disease
12:15pm - 12:30pm Eastern - June 7, 2021
Raz Dvir Szternfeld, MS, Weizmann Institute of Science
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Short Talk: Myokine Irisin Is a Critical Regulator of Cognitive Function
12:30pm - 12:45pm Eastern - June 7, 2021
Christiane D. Wrann, PhD, Massachusetts General Hospital
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Short Talk: Highly Conserved Glial Pathology and Human-Specific Neuronal Pathology Promote Neurodegeneration in FTLD-GRN
12:45pm - 01:00pm Eastern - June 7, 2021
Elise Marsan, PhD, University of California, San Francisco
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

From Therapeutic Targets to Clinic
01:00pm - 02:30pm Eastern - June 7, 2021
Joseph W. Lewcock, PhD, Co-Chair, Denali Therapeutics; Charlotte J. Sumner, MD, Co-Chair, Johns Hopkins School of Medicine
Track: From Therapeutic Targets to Clinic

Monday
The Evolving Challenges of Gene Targeted Therapeutics for SMA
01:00pm - 01:25pm Eastern - June 7, 2021
Charlotte J. Sumner, MD, Johns Hopkins School of Medicine
Track: From Therapeutic Targets to Clinic

Monday
Engineering Gene-Based Medicines for the Brain
01:25pm - 01:50pm Eastern - June 7, 2021
Beverly L. Davidson, PhD, Children’s Hospital of Philadelphia and University of Pennsylvania
Track: From Therapeutic Targets to Clinic

Monday
IPSC-Derived Dopaminergic Neurons and Parkinson's Disease Therapy
01:50pm - 02:15pm Eastern - June 7, 2021
Lorenz Studer, MD, Memorial Sloan Kettering Cancer Center
Track: From Therapeutic Targets to Clinic

Monday
Short Talk: Discovering and Reversing the Metabolic Consequences of APOE4 in iPSC-Derived Glia
02:15pm - 02:30pm Eastern - June 7, 2021
Priyanka Narayan, PhD, National Institute of Health
Track: From Therapeutic Targets to Clinic

Genetic Contributions to Neurodegeneration
09:00am - 10:20am Eastern - June 8, 2021
Valina L. Dawson, PhD, Co-Chair, Johns Hopkins University School of Medicine; Alison Goate, PhD, Co-Chair, Icahn School of Medicine at Mount Sinai
Track: Genetic Contributions to Neurodegeneration

Tuesday
Human Genetics Implicates Microglial Function in Alzheimer’s Disease Risk
09:00am - 09:25am Eastern - June 8, 2021 | Room: V300 - Ian
Alison Goate, PhD, Icahn School of Medicine at Mount Sinai
Track: Genetic Contributions to Neurodegeneration

Tuesday
Immune Contributions to Early-Onset Neurodegenerative Disease
09:25am - 09:50am Eastern - June 8, 2021 | Room: V300 - Ian
Jennifer Yokoyama, PhD, University of California, San Francisco
Track: Genetic Contributions to Neurodegeneration

Tuesday
Short Talk: Modeling the Impact of AD Genetic Risk on Microglia States and Function
09:50am - 10:05am Eastern - June 8, 2021 | Room: V300 - Ian
Martine Therrien, PhD, Broad Institute
Track: Genetic Contributions to Neurodegeneration

Tuesday
Short Talk: Impact of PLCG2 Alzheimer's Disease Risk Variants on Microglia Biology and Disease Pathogenesis
10:05am - 10:20am Eastern - June 8, 2021 | Room: V300 - Ian
Andy Po-Yi Tsai, MS, Indiana University School of Medicine
Track: Genetic Contributions to Neurodegeneration

Cellular Pathways Targeted by Neurodegeneration
10:20am - 11:30am Eastern - June 8, 2021
Alison Goate, PhD, Co-Chair, Icahn School of Medicine at Mount Sinai; Valina L. Dawson, PhD, Co-Chair, Johns Hopkins University School of Medicine
Track: Cellular Pathways Targeted by Neurodegeneration

Tuesday
Mechanism of A-Synuclein-Mediated Neurodegeneration
10:20am - 10:45am Eastern - June 8, 2021
Valina L. Dawson, PhD, Johns Hopkins University School of Medicine
Track: Cellular Pathways Targeted by Neurodegeneration

Tuesday
Short Talk: Synapsin and Synaptic Vesicle Condensates Recruit alpha-Synuclein
10:45am - 11:00am Eastern - June 8, 2021
Christian Hoffmann, PhD, German Center for Neurodegenerative Diseases - DZNE
Track: Cellular Pathways Targeted by Neurodegeneration

Tuesday
Short Talk: Cerebellar Degeneration in ARSACS Disease Linked to Tau Hyperphosphorylation and Membrane-Protein Disruption
11:00am - 11:15am Eastern - June 8, 2021
Kathryn M. Hixson, PhD, UNC Chapel Hill
Track: Cellular Pathways Targeted by Neurodegeneration

Tuesday
Short Talk: Identification of Small Molecule Drugs that Target Apolipoprotein E4-Catalyzed Amyloid-β Fibrillization: A New Therapeutic Approach to Alzheimer’s Disease
11:15am - 11:30am Eastern - June 8, 2021
Noah Johnson, PhD, University of Colorado Anschutz Medical Campus
Track: Cellular Pathways Targeted by Neurodegeneration

Glial Contributions to Neurodegeneration
12:05pm - 02:25pm Eastern - June 8, 2021
Michael T. Heneka, MD, Co-Chair, German Center for Neurodegenerative Diseases; Mathew M. Blurton-Jones, PhD, Co-Chair, University of California, Irvine
Track: Glial Contributions to Neurodegeneration

Tuesday
Novel Genetic Tools for Studying Myeloid Cells in the CNS
12:05pm - 12:25pm Eastern - June 8, 2021 | Room: V300 - Ian
Marco Prinz, MD, University of Freiburg
Track: Glial Contributions to Neurodegeneration

Tuesday
Microglia Shape Neuronal and Vascular Responses via Compartment-Specific Purinergic Mechanisms
12:25pm - 12:50pm Eastern - June 8, 2021 | Room: V300 - Ian
Ádám Dénes, PhD, Hungarian Academy of Sciences
Track: Glial Contributions to Neurodegeneration

Tuesday
Control of Neuron Activity by Microglia
12:50pm - 01:15pm Eastern - June 8, 2021 | Room: V300 - Ian
Anne Schaefer, MD, PhD, Mount Sinai School of Medicine
Track: Glial Contributions to Neurodegeneration

Tuesday
Inflammasome Activation in Alzheimer's Disease
01:15pm - 01:40pm Eastern - June 8, 2021 | Room: V300 - Ian
Michael T. Heneka, MD, German Center for Neurodegenerative Diseases
Track: Glial Contributions to Neurodegeneration

Tuesday
Short Talk: Astrocytic BMAL1 Regulates Protein Aggregation in Mouse Models of Alpha-Synuclein and Tau Pathology
01:55pm - 02:10pm Eastern - June 8, 2021 | Room: V300 - Ian
Patrick W. Sheehan, BS, Washington University in St. Louis
Track: Glial Contributions to Neurodegeneration

Tuesday
Short Talk: Loss of NPC1 Enhances Phagocytic Uptake and Impairs Lipid Trafficking in Microglia
02:10pm - 02:25pm Eastern - June 8, 2021 | Room: V300 - Ian
Sabina Tahirovic, PhD, Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. - DZNE
Track: Glial Contributions to Neurodegeneration

Tuesday
[Joint Session] Meet the Editors Roundtable
03:30pm - 04:30pm Eastern - June 8, 2021
Swapnika Ramu, PhD, Cell Press; Gabriel A. Gasque, PhD, PLOS (Public Library of Science); Sophie Morgan, PhD, Nature Communications; Tim Spencer, PhD, Journal of Cell Biology (JCB)
Track: Keystone Symposia Roundtables

Phase Separation, Protein Aggregation and Transmission
09:00am - 10:45am Eastern - June 9, 2021
Eric J. Huang, MD, PhD, Co-Chair, University of California, San Francisco; Virginia M. Y. Lee, PhD, Co-Chair, University of Pennsylvania School of Medicine
Track: Phase Separation, Protein Aggregation and Transmission

Wednesday
Phase Separation of RNA Binding Proteins in Neurodegeneration
09:00am - 09:25am Eastern - June 9, 2021 | Room: V300 - Ian
J. Paul Taylor, MD, PhD, St. Jude Children's Research Hospital
Track: Phase Separation, Protein Aggregation and Transmission

Wednesday
Cryo-EM Structures of Amyloid Filaments from Human Brain
09:25am - 09:50am Eastern - June 9, 2021 | Room: V300 - Ian
Sjors Scheres, PhD, MRC Laboratory of Molecular Biology
Track: Phase Separation, Protein Aggregation and Transmission

Wednesday
Tau and A-Synuclein Aggregation and Spreading
09:50am - 10:15am Eastern - June 9, 2021 | Room: V300 - Ian
Virginia M. Y. Lee, PhD, University of Pennsylvania School of Medicine
Track: Phase Separation, Protein Aggregation and Transmission

Wednesday
Short Talk: Nuclear Accumulation of CHMP7 Initiates Nuclear Pore Complex Injury and Subsequent TDP-43 Dysfunction in Sporadic and Familial ALS
10:15am - 10:30am Eastern - June 9, 2021 | Room: V300 - Ian
Alyssa Coyne, PhD, Johns Hopkins University School of Medicine
Track: Phase Separation, Protein Aggregation and Transmission

Wednesday
Short Talk: Role of RAB7A Mutations in Charcot-Marie-Tooth Type 2B Disease
10:30am - 10:45am Eastern - June 9, 2021 | Room: V300 - Ian
Roberta Romano, PhD, University of Salento
Track: Phase Separation, Protein Aggregation and Transmission

Epigenetics and Transcriptomics of the Aging Brain
10:45am - 01:00pm Eastern - June 9, 2021
Li-Huei Tsai, PhD, Co-Chair, Massachusetts Institute of Technology; Richard M. Ransohoff, MD, Co-Chair, Harvard Medical School
Track: Epigenetics and Transcriptomics of the Aging Brain

Wednesday
Transcriptomic Dissection of Alzheimer’s Disease at the Single Cell Resolution
10:45am - 11:10am Eastern - June 9, 2021
Li-Huei Tsai, PhD, Massachusetts Institute of Technology
Track: Epigenetics and Transcriptomics of the Aging Brain

Wednesday
Epigenetics and Systems Biology of Alzheimer's Disease
11:10am - 11:35am Eastern - June 9, 2021
Philip L. De Jager, MD, PhD, Columbia University Medical Center
Track: Epigenetics and Transcriptomics of the Aging Brain

Wednesday
Neuro-Immune Interactions in the Aging Neurogenic Niche
12:05pm - 12:30pm Eastern - June 9, 2021
Anne Brunet, PhD, Stanford University
Track: Epigenetics and Transcriptomics of the Aging Brain

Wednesday
Short Talk: Multi-Tissue High-Throughput Proteomics Profiling for Neurodegenerative Disease
12:30pm - 12:45pm Eastern - June 9, 2021
Carlos Cruchaga, PhD, Washington University School of Medicine
Track: Epigenetics and Transcriptomics of the Aging Brain

Wednesday
Short Talk: Transposable Element Insertions Associated with Risk of Neurologic and Psychiatric Diseases
12:45pm - 01:00pm Eastern - June 9, 2021
Hyo Won Ahn, MS, National Institute of Child Health and Human Development
Track: Epigenetics and Transcriptomics of the Aging Brain

Modeling Neuro-Immune Interactions in Neurodegeneration
01:00pm - 02:40pm Eastern - June 9, 2021
Li-Huei Tsai, PhD, Co-Chair, Massachusetts Institute of Technology; Mathew M. Blurton-Jones, PhD, Co-Chair, University of California, Irvine
Track: Modeling Neuro-Immune Interactions in Neurodegeneration

Wednesday
Cerebral Organoids and Neurodegeneration
01:00pm - 01:25pm Eastern - June 9, 2021 | Room: V300 - Ian
Fred H. Gage, PhD, The Salk Institute for Biological Studies
Track: Modeling Neuro-Immune Interactions in Neurodegeneration

Wednesday
Multiple Sclerosis Neurorepair – A Drug Discovery Perspective
01:25pm - 01:50pm Eastern - June 9, 2021 | Room: V300 - Ian
Track: Modeling Neuro-Immune Interactions in Neurodegeneration

Wednesday
Neuro-Immune Interactions in AD Models
01:50pm - 02:15pm Eastern - June 9, 2021 | Room: V300 - Ian
Mathew M. Blurton-Jones, PhD, University of California, Irvine
Track: Modeling Neuro-Immune Interactions in Neurodegeneration

Wednesday
Short Talk: CRISPRi-based Genetic Screens in iPSC-Derived 3D Neuron-Astrocyte-Microglia iAssembloids
02:15pm - 02:30pm Eastern - June 9, 2021 | Room: V300 - Ian
Emmy Li, BS, University of California, San Francisco
Track: Modeling Neuro-Immune Interactions in Neurodegeneration

Wednesday
Closing Remarks
02:30pm - 02:40pm Eastern - June 9, 2021 | Room: V300 - Ian
Track: Modeling Neuro-Immune Interactions in Neurodegeneration