Below are references mentioned during the roundtable discussion.  These items include scientific articles, abbreviations, news articles, panelists affiliations and  graphical representations of chemical structures.


Orally Active Macrocyclic Peptide: Cyclosporine


Bioavailability and pharmacokinetics of cyclosporine formulations: Neoral® vs Sandimmune®

Int. T. Dermatol. 1997, 36 (Suppl. 1), 1-6

Orally Active Peptide: Ozempic (semaglutide)

Davies et al.

Effect of Oral Semaglutide Compared with Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients with Type 2 Diabetes. A Randomized Clinical Trial

JAMA 2017, 318(15), 1460-1470


Design of Orally Bioavailable Macrocyclic Peptides

Boehm et al.

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators

J. Med. Chem. 2017, 60(23), 9653-9663

DOI: 10.1021/acs.jmedchem.7b01028

Enhancing Oral Drug Absorption

Alani and Robinson

Mechanistic understanding of oral drug absorption enhancement of cromolyn sodium by an amino acid derivative

Pharm. Res. 2008, 25(1), 48-54

DOI: 10.1007/s11095-007-9438-6

Size of Drug Space


The Chemical Space Project

Accts. Chem. Res. 2015 48(3), 722-730

DOI: 10.1021/ar500432k

Top 100 Drugs by Sales and Number of Prescriptions

Combinatorial Chemistry Perspective

Moos et al.

Combinatorial chemistry: Oh what a decade or two can do

Mol. Divers. 2009, 13, 241–245

DOI 10.1007/s11030-009-9127-y

Lipinski’s Rule of Five

Lipinski et al.

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Adv. Drug Delivery Rev. 1997, 23, 3−25

Beyond the Rule of Five

Doak et al.

How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets

J. Med. Chem. 2016, 59(6), 2312-2327

DOI: 10.1021/acs.jmedchem.5b01286

Drug Discovery Book

Miller et al.

Managing the Drug Discovery Process

Elsevier 2017 

Fragment-Based Drug Discovery

Erlanson et al.

Twenty years on: the impact of fragments on drug discovery

Nat. Rev. Drug Discov. 2016, 15, 605-619

DOI: 10.1038/nrd.2016.109

DNA-Encoded Libraries

Goodnow et al.

DNA-encoded chemistry: enabling the deeper sampling of chemical space

Nat. Rev. Drug Discov. 2017, 16, 131-147

DOI: 10.1038/nrd.2016.213

Covalent Drugs

De Cesco et al.

Covalent inhibitors design and discovery

Eur. J. Med. Chem. 2017, 138, 96-114

DOI: 10.1016/j.ejmech.2017.06.019 



Complex Organic Synthesis: Structure, Properties, and/or Function? 

Isr J Chem 2018, 58, 142-150 
DOI: 10.1002/ijch.201800016


Natural Product Total Synthesis: As Exciting as Ever and Here To Stay 

J Am Chem Soc 2018, 140, 4751−4755 
DOI: 10.1021/jacs.8b02266

Betzer and Ardisson
Discodermolide: Total Synthesis of Natural Product and Analogues 

Strategies and Tactics in Organic Synthesis, Vol 11, Chapter 3, 51-84DOI: 10.1016/B978-0-08-100023-6.00003-8

New Drugs Article

WSJ Article

ROCS Website

First Approved Antibody: Orthoclone OKT3 in 1986

Approved CAR-T Therapies

Kymriah (tisagenlecleucel)

Yescarta (axicabtagene ciloleucel)


ADC, Antibody Drug Conjugate

BTK, Bruton’s Tyrosine Kinase

CAR-T, Chimeric Antigen Receptor T-Cell Therapy

c-kit, a Human Tumor Biomarker, Mast Cell/Stem Cell Growth Factor Receptor, Proto-Oncogene Tyrosine Protein Kinase, or CD117

CRO, Contract Research Organization

CYP3A4, Cytochrome P-450 3A4, an enzyme (found mainly in liver and intestines) that oxidizes small foreign organic chemicals—xenobiotics, including drugs and toxins—to remove them from the body

DEL, DNA-Encoded Library

DNA, Deoxyribonucleic Acid

RNA, Ribonucleic Acid

ROCS, Rapid Overlay of Chemical Structures

SAR, Structure-Activity Relationship(s)


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