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Higher-Order Chromatin Architecture in Time and Space

November 15-17, 2021 | 10:00AM EST | 3:00PM UTC | 4:00PM CET*
*Program is in development and subject to change


The live portion of this conference has concluded and all presentations are now available for purchase on demand. Registrants to the live event may access this content anytime for up to 9 months following the event.

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Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs, and looping interactions. As genome-wide chromatin architecture maps become widely available, the field is shifting focus from mapping to understanding the dynamics of such structures in development, the cell cycle, and on short time scales in single cells. A critical emerging goal will be to unravel the cause and effect relationship between genome folding and functions such as transcription, replication, recombination, and stability/maintenance. There is also a great need to evaluate the organizing principles governing chromatin topology across many biological conditions and genetic perturbations. Moreover, the role for 3D genome misfolding in the onset and progression of a wide range of human disease states remains an area of high interest across multiple disciplines and organ systems. Overall, this Keystone eSymposia virtual event is meant to highlight new frontiers across disciplines in tackling the dynamics and functional roles of the 3D genome in cellular functions across time and space in development and disease.

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Regular Registration Rate: $275 USD
Student Registration Rate: $150 USD


Abstract Submission
‣ For Short Talk Consideration: Passed
‣ For ePoster Presentation: Passed
Final ePoster / SciTalk Submission: Passed
Financial Aid Application: Passed

*Abstract submission is required in order to submit an ePoster and/or SciTalk


Program Details

Speaking at this eSymposia

Gerd A. Blobel

Children's Hospital of Philadelphia, USA

Alistair Boettiger

Stanford University, USA

Clifford P. Brangwynne

Princeton University, USA

Benoit G. Bruneau

Gladstone Institutes, USA

Long Cai

California Institute of Technology, USA

Bradley R. Cairns

HHMI/University of Utah, USA

Daniele Canzio

University of California, San Francisco, USA

Elzo de Wit

Netherlands Cancer Institute, Netherlands

Job Dekker

University of Massachusetts Medical School, USA

Luca Giorgetti

Friedrich Miescher Institute for Biomedical Research, Switzerland

Anders Sejr Hansen

Massachusetts Institute of Technology, USA

Gary Karpen

University of California, Berkeley, USA

Nancy E. Kleckner

Harvard University, USA

Minoree Kohwi

Columbia University, USA

Terumi Kohwi-Shigematsu

University of California, San Francisco, USA

Jeannie T. Lee

Massachusetts General Hospital / Harvard Medical School, USA

Erez Lieberman-Aiden

Baylor College of Medicine, USA

Stavros Lomvardas

Columbia University, USA

Leonid Mirny

Massachusetts Institute of Technology, USA

Daan Noordermeer

Institute for Integrative Biology of the Cell, France

Clodagh C. O'Shea

The Salk Institute for Biological Studies, USA

Jennifer E. Phillips-Cremins

University of Pennsylvania, USA

Ana Pombo

Max Delbrück Centre for Molecular Medicine, Germany

Karen L. Reddy

Johns Hopkins University, USA

Bing Ren

Ludwig Institute for Cancer Research, USA

François Spitz

Institut Pasteur, France

Amos Tanay

Weizmann Institute, Israel

Bas van Steensel

Netherlands Cancer Institute, Netherlands

Ting (C.-ting) Wu

Harvard Medical School, USA





Additional Support




Funding for this conference was made possible (in part) by Grant No. [GRANT NUMBER - UPDATE] from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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The views expressed in this eSymposia are those of the participants and not necessarily of the participants’ organizations or of Keystone Symposia.


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