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Metabolic Decisions in Development and Disease

March 24-25, 2021 | 10:00AM EDT | 2:00PM UTC | 3:00PM CET*
*Program is in development and subject to change


The live portion of this conference has concluded and all presentations are now available for purchase on demand. Registrants to the live event may access this content anytime for up to 9 months following the event.

 Free Access to On Demand Content to Scientists from Low-and Middle-Income Countries

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Metabolism was once regarded as a homeostatic, housekeeping process that supported but did not instruct cell signaling, gene expression and other networks. In recent years, it has become apparent that metabolism is intimately intertwined with many other networks that determine cellular fate and tissue function, and that metabolites can transmit signals within and between cells. The impact of metabolic signaling is illustrated by the consequences of its dysregulation; we now understand that many diseases involve pathologically altered metabolism. Mutations in metabolic enzymes underlie numerous developmental disorders, and metabolic alterations in malignant cells impair cellular differentiation and fuel tumor growth. These observations have rekindled interest in disease-oriented metabolism research, which now benefits from increasingly sophisticated analytical and computational tools to understand metabolism and to localize important activities in space and time. With this new symposium, we aim to capitalize on both the technological and conceptual momentum of this budding field. 

The unifying theme of this symposium is that proper development requires exquisite metabolic control, and that perturbed metabolism can result in developmental diseases. The symposium will bring together scientists exploring how metabolites impact cellular and developmental decisions in a diverse range of model systems, and mechanisms underlying developmental disorders caused by aberrant metabolism. Topics will include – but need not be confined to – the epigenetic roles of metabolites and their oncogenic potential, signalling roles of metabolites across organs, metabolic control of development, and the impact of microbiota-mediated signaling in ageing and metabolic disease. Collectively, we hope to foster collaborations across a range of disciplines, provide biological questions for emerging technologies, and ultimately develop a new conceptual framework for the study of the instructive roles of metabolites in biology and disease.

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Regular Registration Rate: $275 USD
Student Registration Rate: $150 USD


Abstract Submission:
‣ For Short Talk Consideration: Passed
‣ For Poster Booth: Passed
ePoster / SciTalk Submission: Passed
Financial Aid Application: Passed

*Abstract submission is required in order to submit an ePoster and/or Scitalk


Program Details

Keynote Speaker

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Olivier Pourquié
Harvard Medical School

Speaking at this eSymposia

Theodore Alexandrov

European Molecular Biology Laboratory, Germany

Alexander Aulehla

European Molecular Biology Laboratory, Germany

Navdeep S. Chandel

Northwestern University, USA

Heather Christofk

University of California, Los Angeles, USA

Ralph J. DeBerardinis

University of Texas Southwestern Medical Center, USA

Ayelet Erez

Weizmann Institute of Science, Israel

Sarah-Maria Fendt

VIB Leuven, Belgium

Lydia Finley

Memorial Sloan Kettering Cancer Center, USA

Wendy S. Garrett

Harvard School of Public Health, USA

Alex Gould

Francis Crick Institute, UK

Lora V. Hooper

University of Texas Southwestern Medical Center, USA

Jason Locasale

Duke University School of Medicine, USA

Irene Miguel-Aliaga

Imperial College London, UK

Norbert Perrimon

Harvard Medical School, USA

Olivier Pourquié

Harvard Medical School, USA

Joshua D. Rabinowitz

Princeton University, USA

Markus Ralser

Francis Crick Institute, UK

Jared Rutter

University of Utah, USA

Aurelio Teleman

Deutsches Krebsforschungszentrum, Germany

Tadashi Uemura

Kyoto University, Japan

A.J. Marian Walhout

University of Massachusetts Medical School, USA

Kathryn E. Wellen

University of Pennsylvania, USA





Additional Support




Funding for this conference was made possible (in part) by 1R13DK128974-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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