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Metabolic Decisions in Development and Disease

March 24-25, 2021 | 10:00AM EDT | 2:00PM UTC | 4:00PM CEST*
*Program is subject to change

Metabolism was once regarded as a homeostatic, housekeeping process that supported but did not instruct cell signaling, gene expression and other networks. In recent years, it has become apparent that metabolism is intimately intertwined with many other networks that determine cellular fate and tissue function, and that metabolites can transmit signals within and between cells. The impact of metabolic signaling is illustrated by the consequences of its dysregulation; we now understand that many diseases involve pathologically altered metabolism. Mutations in metabolic enzymes underlie numerous developmental disorders, and metabolic alterations in malignant cells impair cellular differentiation and fuel tumor growth. These observations have rekindled interest in disease-oriented metabolism research, which now benefits from increasingly sophisticated analytical and computational tools to understand metabolism and to localize important activities in space and time. With this new symposium, we aim to capitalize on both the technological and conceptual momentum of this budding field. 

The unifying theme of this symposium is that proper development requires exquisite metabolic control, and that perturbed metabolism can result in developmental diseases. The symposium will bring together scientists exploring how metabolites impact cellular and developmental decisions in a diverse range of model systems, and mechanisms underlying developmental disorders caused by aberrant metabolism. Topics will include – but need not be confined to – the epigenetic roles of metabolites and their oncogenic potential, signalling roles of metabolites across organs, metabolic control of development, and the impact of microbiota-mediated signaling in ageing and metabolic disease. Collectively, we hope to foster collaborations across a range of disciplines, provide biological questions for emerging technologies, and ultimately develop a new conceptual framework for the study of the instructive roles of metabolites in biology and disease.


Regular Registration Rate: $275 USD
Student Registration Rate: $150 USD


Scholarships: January 26, 2021
Abstract Submission: February 9, 2021


Financial Aid Opportunities

Graduate students and postdoctoral fellows, as well as individuals from low- and middle- income countries (all career stages) working in science and medicine related fields, are eligible to apply for a FREE registration code.

Find out more about financial aid opportunities here!

Call For Abstracts

Showcase your work to global audiences on the eSymposia platform!

ePoster presenters will be provided with their own dedicated page on the event website to display their work in multiple formats and interact with meeting participants. ePoster features include:

  • Abstract
  • Poster PDF for download
  • SciTalk – up to 5 minute video presentation, available on-demand
  • Live chat function to answer audience questions in real-time
  • Contact information for private follow-up discussion

To submit your work for an ePoster presentation, complete the event registration process and you will be given access to the “Submit an Abstract” tab on the event homepage.

Program Details

Speaking at this eSymposia

Theodore Alexandrov

European Molecular Biology Laboratory, Germany

Alexander Aulehla

European Molecular Biology Laboratory, Germany

Navdeep S. Chandel

Northwestern University, USA

Heather Christofk

University of California, Los Angeles, USA

Ralph J. DeBerardinis

University of Texas Southwestern Medical Center, USA

More program details will be available soon.

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Funding for this conference was made possible (in part) by 1R13CA246936-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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The views expressed in this eSymposia are those of the participants and not necessarily of the participants’ organizations or of Keystone Symposia.

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