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Metabolic Decisions in Development and Disease

March 24-25, 2021 | 10:00AM EDT | 2:00PM UTC | 3:00PM CET*
*Program is in development and subject to change



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Metabolism was once regarded as a homeostatic, housekeeping process that supported but did not instruct cell signaling, gene expression and other networks. In recent years, it has become apparent that metabolism is intimately intertwined with many other networks that determine cellular fate and tissue function, and that metabolites can transmit signals within and between cells. The impact of metabolic signaling is illustrated by the consequences of its dysregulation; we now understand that many diseases involve pathologically altered metabolism. Mutations in metabolic enzymes underlie numerous developmental disorders, and metabolic alterations in malignant cells impair cellular differentiation and fuel tumor growth. These observations have rekindled interest in disease-oriented metabolism research, which now benefits from increasingly sophisticated analytical and computational tools to understand metabolism and to localize important activities in space and time. With this new symposium, we aim to capitalize on both the technological and conceptual momentum of this budding field. 

The unifying theme of this symposium is that proper development requires exquisite metabolic control, and that perturbed metabolism can result in developmental diseases. The symposium will bring together scientists exploring how metabolites impact cellular and developmental decisions in a diverse range of model systems, and mechanisms underlying developmental disorders caused by aberrant metabolism. Topics will include – but need not be confined to – the epigenetic roles of metabolites and their oncogenic potential, signalling roles of metabolites across organs, metabolic control of development, and the impact of microbiota-mediated signaling in ageing and metabolic disease. Collectively, we hope to foster collaborations across a range of disciplines, provide biological questions for emerging technologies, and ultimately develop a new conceptual framework for the study of the instructive roles of metabolites in biology and disease.

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Pricing:

Regular Registration Rate: $275 USD
Student Registration Rate: $150 USD

Deadlines:

Abstract Submission:
‣ For Short Talk Consideration: Passed
‣ For Poster Booth: Passed
ePoster / SciTalk Submission: Passed
Financial Aid Application: Passed

*Abstract submission is required in order to submit an ePoster and/or Scitalk

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Program Details



Keynote Speaker


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Olivier Pourquié
Harvard Medical School




Speaking at this eSymposia


Theodore Alexandrov

European Molecular Biology Laboratory, Germany


Alexander Aulehla

European Molecular Biology Laboratory, Germany


Navdeep S. Chandel

Northwestern University, USA


Heather Christofk

University of California, Los Angeles, USA


Ralph J. DeBerardinis

University of Texas Southwestern Medical Center, USA


Ayelet Erez

Weizmann Institute of Science, Israel


Sarah-Maria Fendt

VIB Leuven, Belgium


Lydia Finley

Memorial Sloan Kettering Cancer Center, USA


Wendy S. Garrett

Harvard School of Public Health, USA


Alex Gould

Francis Crick Institute, UK


Lora V. Hooper

University of Texas Southwestern Medical Center, USA


Jason Locasale

Duke University School of Medicine, USA


Irene Miguel-Aliaga

Imperial College London, UK


Norbert Perrimon

Harvard Medical School, USA


Olivier Pourquié

Harvard Medical School, USA


Joshua D. Rabinowitz

Princeton University, USA


Markus Ralser

Francis Crick Institute, UK


Jared Rutter

University of Utah, USA


Aurelio Teleman

Deutsches Krebsforschungszentrum, Germany


Tadashi Uemura

Kyoto University, Japan


A.J. Marian Walhout

University of Massachusetts Medical School, USA


Kathryn E. Wellen

University of Pennsylvania, USA






Sponsors


 

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Additional Support



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Funding for this conference was made possible (in part) by 1R13DK128974-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.




Media-in-Kind Support


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This new virtual meeting format came out of difficult circumstances, but your commitment to scientific progress is what inspired us to launch Keystone eSymposia. In these virtual meetings, we are capturing the same innovative essence of our in-person meetings that you've all created as a scientific community. Here, Debbie Johnson, our CEO, explains how we're going to do that.







The views expressed in this eSymposia are those of the participants and not necessarily of the participants’ organizations or of Keystone Symposia.






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