Error loading player: No playable sources found

  To view this video content in its entirety, click on the "Access Content" button and login to your account.

If you do not have an account, register for free.

Please note that the account you create here is different than your Keystone Symposia account at www.keystonesymposia.org used to register for our multi-day conferences and is uniquely for viewing our virtual content.


Improved Vaccines for the Control of East Coast Fever for Cattle in Africa

Free
Standard Price
This product is also available as part of the following products:

East coast fever is a fatal bovine disease caused by the apicomplexan parasite, Thieleria parva, which is transmitted by the brown ear tick Rhipicephalus appendiculatus. The disease is found in 11 countries across eastern, central and southern Africa, killing a million cattle and resulting in economic losses exceeding $300 million per year.

Cattle can be protected against ECF by a vaccination procedure known as the Infection and Treatment Method (ITM) where animals are inoculated with live T. parva sporozoites and simultaneously treated with a long-acting antibiotic. However, the vaccine is expensive and therefore other, more affordable sub-unit vaccines are needed for use in these low- resource settings.

In this discussion, we will explore:

  • What is wrong with the current vaccine? Does it need improvement?
  • How can we improve the current live vaccine?
  • What might be a better vaccine? What is the sub-unit vaccine and what do we know about it?
  • What is needed for a sub-unit vaccine to:
    • Induce antibody-based immunity by targeting the sporozoites stage of the parasite?
    • Induce antibody-based immunity by targeting the sporozoites stage of the parasite?
    • Induce T-cell mediated immunity by targeting the schizont stage of the parasite?
    • Be effective in animal/CTL models?
  • What are the challenges faced in developing a sub-unit vaccine?



custom image

#VKSecfever





This Keystone Symposia ePanel was co-organized with:


custom image







The views expressed in this ePanel are those of the participants and not necessarily of the participants’ organizations or of Keystone Symposia.




Speakers

Speaker Image for Vish Nene
International Livestock Research Institute
Speaker Image for Lucilla Steinaa
International Livestock Research Institute
Speaker Image for Henry Kiara
International Livestock Research Institute

Related Products

Thumbnail for HIV: Antibody Functions Beyond Neutralization
HIV: Antibody Functions Beyond Neutralization
Antibodies that neutralize HIV can potentially provide sterilizing protection against the virus by blocking infection of cells…
Thumbnail for Establishment of vaccine platform technologies for African swine fever virus as the first target
Establishment of vaccine platform technologies for African swine fever virus as the first target
_THIS KEYSTONE SYMPOSIA SCITALK WAS MADE POSSIBLE IN COLLABORATION WITH:_
Thumbnail for Preparing for the Next Pandemic:  The Emerging Infectious Disease Threat
Preparing for the Next Pandemic: The Emerging Infectious Disease Threat
Emerging infectious diseases are relatively little understood. Their periodic, unpredictable outbreaks can quickly transform into global pandemics, as was the case with SARS and avian influenza…
Thumbnail for Mosquito-Borne Diseases: From Long Time Foes to Emerging Threats
Mosquito-Borne Diseases: From Long Time Foes to Emerging Threats
Arboviruses are a large group of viruses transmitted by insects such as mosquitos and ticks…
Privacy Policy Update: We value your privacy and want you to understand how your information is being used. To make sure you have current and accurate information about this sites privacy practices please visit the privacy center by clicking here.