Using mitochondrial TOP1 (TOP1mt) to probe the involvement of mitochondria in Systemic Lupus Erythematosus

This product is not available for individual purchase, but it is available as part of the following products:

Using mitochondrial TOP1 (TOP1mt) to probe the involvement of mitochondria in Systemic Lupus Erythematosus
 
Hongliang Zhang1, Mariana Kaplan2, and Yves Pommier1
1Developmental therapeutics Branch, CCR, NCI
2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH
 
Systemic lupus erythematosus (SLE), also known simply as lupus, is a chronic, multisystem autoimmune disorder. The standard lupus tests of anti-nuclear antibodies and anti-dsDNA antibodies establish the central role of nuclear components in the onset of lupus symptoms. Since both nuclear and mitochondrial domains contain DNA, we investigated the involvement of mitochondria in lupus. We take advantage of the facts that both nuclei and mitochondria have their own topoisomerase I—TOP1 and TOP1mt, respectively. We screened the lupus sera against TOP1 and TOP1mt with Enzyme-linked immunosorbent assay (ELISA). With the confirmation of Western blots, it is TOP1mt not TOP1 reacted to the lupus sera, which pointed out the importance of mitochondria in the process of lupus. We speculate that mitochondria play a to-be-realized important role in lupus etiology.
 
· · ·

Related Products

Thumbnail for Vanadium promotes atherosclerosis through induction of VSMC proliferation and migration mediated by p38-mediated ROS-IL-6 production
Vanadium promotes atherosclerosis through induction of VSMC proliferation and migration mediated by p38-mediated ROS-IL-6 production
VANADIUM PROMOTES ATHEROSCLEROSIS THROUGH INDUCTION OF VSMC PROLIFERATION AND MIGRATION MEDIATED BY P38-MEDIATED ROS-IL-6 PRODUCTION
Thumbnail for Vms1 is a release factor for the Ribosome Quality control Complex
Vms1 is a release factor for the Ribosome Quality control Complex
VMS1 IS A RELEASE FACTOR FOR THE RIBOSOME QUALITY CONTROL COMPLEX
Thumbnail for Identification of mitochondrial RNA granules assembly factors and regulators using an image-based siRNA screen
Identification of mitochondrial RNA granules assembly factors and regulators using an image-based siRNA screen
IDENTIFICATION OF MITOCHONDRIAL RNA GRANULES ASSEMBLY FACTORS AND REGULATORS USING AN IMAGE-BASED SIRNA SCREEN
Thumbnail for Novel Functions of Rab24 in Regulating Blood Glucose Homeostasis and Mitochondrial Activity in the Liver
Novel Functions of Rab24 in Regulating Blood Glucose Homeostasis and Mitochondrial Activity in the Liver
NOVEL FUNCTIONS OF RAB24 IN REGULATING BLOOD GLUCOSE HOMEOSTASIS AND MITOCHONDRIAL ACTIVITY IN THE LIVER

Copyright © 2025 Keystone Symposia
Powered by Conexiant DXP
Privacy Policy Update: We value your privacy and want you to understand how your information is being used. To make sure you have current and accurate information about this sites privacy practices please visit the privacy center by clicking here.