Error loading player: No playable sources found

  To view this video content in its entirety, click on the "Access Content" button and login to your account.

If you do not have an account, register for free.

Please note that the account you create here is different than your Keystone Symposia account at www.keystonesymposia.org used to register for our multi-day conferences and is uniquely for viewing our virtual content.


Role of Lactobacillus iners in the Vaginal Microbiota

Free
Standard Price
This product is also available as part of the following products:

Mariya I. Petrova

KU Leuven, Belgium

The vaginal microbial community is typically characterized by abundant lactobacilli. Lactobacillus iners, a fairly recently detected species, is frequently present in the vaginal niche. However, the role of this species in vaginal health is unclear, since it can be identified in normal conditions as well as during vaginal dysbiosis, such as bacterial vaginosis, a condition characterized by an abnormal increase in bacterial diversity and lack of typical lactobacilli. Compared to other Lactobacillus species, L. iners has more complex nutritional requirements and a Gram-variable morphology. L. iners has an unusually small genome, indicative of a symbiotic or parasitic lifestyle, in contrast to other lactobacilli that show niche flexibility and genomes of up to 3-4 Mbp. The presence of specific L. iners genes, such as those encoding iron-sulfur proteins and unique σ-factors, reflects a high degree of niche specification. The genome of L. iners strains also encodes inerolysin, a pore-forming toxin related to vaginolysin of Gardnerella vaginalis. Possibly, this organism may have clonal variants that in some cases promote a healthy vagina, and in other cases are associated with dysbiosis and disease. Future research should examine the exact role of this species and its relationship with the host.

Speaker

Speaker Image for Mariya Petrova
KU Leuven

Related Products

Thumbnail for Immune genes are primed for robust transcription by proximal lncRNAs located in nuclear compartments
Immune genes are primed for robust transcription by proximal lncRNAs located in nuclear compartments
TITLE: IMMUNE GENES ARE PRIMED FOR ROBUST TRANSCRIPTION BY PROXIMAL LNCRNAS LOCATED IN NUCLEAR COMPARTMENTS
Thumbnail for Functional, antigen-specific stem cell memory (TSCM) CD4+ T cells are induced by human M.tuberculosis infection
Functional, antigen-specific stem cell memory (TSCM) CD4+ T cells are induced by human M.tuberculosis infection
Cheleka AM Mpande, One B Dintwe, Munyaradzi Musvosvi, Simbarashe Mabwe, Nicole Bilek, Mark Hatherill, Elisa Nemes and Thomas J Scriba and the SATVI Clinical Immunology Team…
Thumbnail for Ubiquitous gram-positive bacteria in the male urogenital tract are disease causing agents in chronic pelvic pain
Ubiquitous gram-positive bacteria in the male urogenital tract are disease causing agents in chronic pelvic pain
Praveen Thumbikat1, Stephen F. Murphy1, Jonathan F. Anker1, Daniel J. Mazur1, Anthony J…
Thumbnail for The impact of vaginal microbial communities on immune cells essential for pathogen protection and epithelial integrity
The impact of vaginal microbial communities on immune cells essential for pathogen protection and epithelial integrity
Ryan K. Cheu1,2,3, Avid Mohammadi4, Tiffany Hensley-Mcbain1,2, Jennifer Manuzak1,2,3, Alexander S. Zevin1,2, Charlene Miller3, Mark Yudin5, Rupert Kaul4, Nichole R…
Privacy Policy Update: We value your privacy and want you to understand how your information is being used. To make sure you have current and accurate information about this sites privacy practices please visit the privacy center by clicking here.