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Targeted Protein Degradation: From Small Molecules to Complex Organelles

June 7-8, 2021 | 10:00AM EDT | 2:00PM UTC | 4:00PM CEST*
*Program is in development and subject to change


The live portion of this conference has concluded and all presentations are now available for purchase on demand. Registrants to the live event may access this content anytime for up to 9 months following the event.

 Free Access to On Demand Content to Scientists from Low-and Middle-Income Countries

Keystone Symposia welcomes the global scientific community and aims to connect researchers within and across disciplines to accelerate the advancement of biomedical and life sciences. This form may be used for scientists from low- and middle-income countries of all career stages to determine eligibility and request free access to scientific content presented during recent eSymposia events. If eligible, you will be sent an access code for the On Demand content of the eSymposia event(s) of interest.

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Targeted protein degradation plays a critical role in regulating nearly all cellular functions, and as such, its dysfunction is associated with severe pathologies including diseases like cancer, neurodegeneration and age-associated diseases. Therefore, fundamental insights into protein clearance pathways might be harnessed for therapeutic applications against a wide range of diseases. While much progress has been made in revealing mechanisms of autophagy and the ubiquitin-proteasome system, the major protein degradation pathways defined thus far, these fields continue to remain isolated from each other despite the interconnection of these processes. This separation is now leading to an urgent need to discuss the interplay of these pathways at the molecular and cellular levels to integrate our understanding of these processes and how they contribute to disease pathology. This conference will bring together researchers from these different fields, who do not typically interact, to build a holistic and integrated vision of protein degradation. Such an integrative conference highlighting the connections between the different branches of protein degradation research does not yet exist, so this Keystone Symposia conference will be the first of its kind to reshape how these fields interact and collaborate to yield transformative insights into both basic science and disease processes.

Topics of discussion will include:

  1. Substrate recognition and processing by energy-dependent proteases, autophagy and lysosomal pathways
  2. Signals targeting proteins to distinct degradation pathways
  3. Interplay between proteolytic systems and chaperone pathways
  4. Reprogramming degradation with small molecules for therapeutic applications
  5. Degradation programs driving global proteome remodeling

Attendees will be exposed to novel perspectives, as well as methods, techniques and approaches, that will advance research within their field, and across the many different components in the protein degradation landscape.

Apply Here for Free On Demand Access


Regular Registration Rate: $275 USD
Student Registration Rate: $150 USD


Abstract Submission:
‣ For Short Talk Consideration: Passed
‣ For Poster Booth: Passed
ePoster / SciTalk Submission: Passed
Financial Aid Application: Passed

*Abstract submission is required in order to submit an ePoster and/or Scitalk


Program Details

Speaking at this eSymposia

Eric J. Bennett

University of California, San Diego, USA

Carolyn R. Bertozzi

Stanford University, USA

Tim Clausen

Research Institute of Molecular Pathology, IMP, Austria

Della David

Eberhard Karls Universität Tübingen, Germanyy

Raymond J. Deshaies

Amgen, Inc., USA

Ivan Dikic

Goethe University Medical School, Germany

Daniel J. Finley

Harvard University, USA

Judith Frydman

Stanford University, USA

Jonathan Goodwin

Casma Therapeutics, USA

Malene Hansen

Sanford Burnham Prebys Medical Discovery Institute, USA

J. Wade Harper

Harvard Medical School, USA

Ursula Jakob

University of Michigan, USA

Sascha Martens

University of Vienna, Austria

Brenda A. Schulman

Max Planck Institute of Biochemistry, Germany

Michal Sharon

Weizmann Institute of Science, Israel

Anne Simonsen

University of Oslo, Norway

Nicolas H. Thomä

Friedrich Miescher Institute for Biomedical Research, Switzerland

Kylie J. Walters

NCI, National Institutes of Health, USA

Eilika Weber-Ban

ETH Zürich, Switzerland

Ingrid E. Wertz

Genentech, Inc., USA

Hong Zhang

Chinese Academy of Sciences, China


This new virtual meeting format came out of difficult circumstances, but your commitment to scientific progress is what inspired us to launch Keystone eSymposia. In these virtual meetings, we are capturing the same innovative essence of our in-person meetings that you've all created as a scientific community. Here, Debbie Johnson, our CEO, explains how we're going to do that.

The views expressed in this eSymposia are those of the participants and not necessarily of the participants’ organizations or of Keystone Symposia.

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