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Targeted Protein Degradation: From Small Molecules to Complex Organelles

June 7-8, 2021 | 10:00AM EDT | 2:00PM UTC | 4:00PM CEST*
*Program is in development and subject to change


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Protease Machines
10:00am - 01:00pm Eastern - June 7, 2021 | Room: Multi-Room Split Session
Eilika Weber-Ban, PhD, Co-Chair, ETH Zürich; Tim Clausen, PhD, Co-Chair, Research Institute of Molecular Pathology, IMP
Track: Protease Machines

Monday
Substrate Recruitment to Proteasomal Degradation in Mycobacteria
10:00am - 10:25am Eastern - June 7, 2021 | Room: V100 - Atticus
Track: Protease Machines

Monday
Regulation, Substrate Targeting and Reprogramming of the Bacterial ClpC:ClpP Protease
10:25am - 10:50am Eastern - June 7, 2021 | Room: V100 - Atticus
Tim Clausen, PhD, Research Institute of Molecular Pathology, IMP
Track: Protease Machines

Monday
Structural and Mechanistic Insights into Proteasome Function
10:50am - 11:15am Eastern - June 7, 2021 | Room: V100 - Atticus
Kylie J. Walters, PhD, NCI, National Institutes of Health
Track: Protease Machines

Monday
Specific Regulation of the 20S Proteasome Complex
11:15am - 11:40am Eastern - June 7, 2021 | Room: V100 - Atticus
Michal Sharon, PhD, Weizmann Institute of Science
Track: Protease Machines

Monday
Proteome Remodeling by the Ubiquitin-Proteasome System
11:50am - 12:15pm Eastern - June 7, 2021 | Room: V200 - Ronney
Daniel J. Finley, PhD, Harvard University
Track: Protease Machines

Monday
Short Talk: Proximity Labeling Proteomics Reveals Critical Regulators for Inner Nuclear Membrane Protein Degradation in Plants
12:15pm - 12:30pm Eastern - June 7, 2021 | Room: V200 - Ronney
Yangnan Gu, PhD, University of California, Berkeley
Track: Protease Machines

Monday
Short Talk: Structures of Chaperone-Associated Assembly Intermediates Reveal Coordinated Mechanisms of Proteasome Biogenesis
12:30pm - 12:45pm Eastern - June 7, 2021 | Room: V200 - Ronney
John Hanna, MD, PhD, Harvard Medical School
Track: Protease Machines

Monday
Short Talk: Serine and Threonine Phosphorylation Marks Proteins for Degradation by Mitochondrial ClpXP
12:45pm - 01:00pm Eastern - June 7, 2021 | Room: V200 - Ronney
Yue Feng, BS, University of Toronto
Track: Protease Machines

Monday
Meet the Editors Roundtable
02:30pm - 03:30pm Eastern - June 7, 2021
Shawnna Buttery, PhD, Cell Press; Angela R. Parrish, PhD, Springer Nature; Martina Rembold, PhD, EMBO Reports; Nonia Pariente, PhD, PLOS Biology; Petra Gross, PhD, The Company of Biologists
Track: Keystone Symposia Roundtables

Autophagy and Lysosomal Degradation Pathways
05:00pm - 08:00pm Eastern - June 7, 2021 | Room: Multi-Room Split Session
Sascha Martens, PhD, Co-Chair, University of Vienna; Malene Hansen, PhD, Co-Chair, Sanford Burnham Prebys Medical Discovery Institute
Track: Autophagy and Lysosomal Degradation Pathways

Monday
Protein Degradation by Selective Autophagy
05:00pm - 05:25pm Eastern - June 7, 2021 | Room: V100 - Atticus
Sascha Martens, PhD, University of Vienna
Track: Autophagy and Lysosomal Degradation Pathways

Monday
Selective Autophagy Pathways
05:25pm - 05:50pm Eastern - June 7, 2021 | Room: V100 - Atticus
Anne Simonsen, PhD, University of Oslo
Track: Autophagy and Lysosomal Degradation Pathways

Monday
Role of Autophagy in Aging and Disease
05:50pm - 06:15pm Eastern - June 7, 2021 | Room: V100 - Atticus
Malene Hansen, PhD, Sanford Burnham Prebys Medical Discovery Institute
Track: Autophagy and Lysosomal Degradation Pathways

Monday
Phase Separation and Autophagy
06:15pm - 06:40pm Eastern - June 7, 2021 | Room: V100 - Atticus
Hong Zhang, PhD, Chinese Academy of Sciences
Track: Autophagy and Lysosomal Degradation Pathways

Monday
Control of TFEB/TFE3 Family Transcription Factors through FLCN Sequestration
06:50pm - 07:15pm Eastern - June 7, 2021 | Room: V200 - Ronney
Jonathan Goodwin, PhD, Casma Therapeutics
Track: Autophagy and Lysosomal Degradation Pathways

Monday
Short Talk: Role of FAM134 Family Members in Endoplasmic Reticulum Remodeling, ER-Phagy and Collagen Quality Control
07:15pm - 07:30pm Eastern - June 7, 2021 | Room: V200 - Ronney
Alessio Reggio, PhD, Telethon Institute of Genetics and Medicine - TIGEM
Track: Autophagy and Lysosomal Degradation Pathways

Monday
Short Talk: Reconstitution of Cargo-Induced LC3 Lipidation in Mammalian Selective Autophagy
07:30pm - 07:45pm Eastern - June 7, 2021 | Room: V200 - Ronney
Chunmei Chang, PhD, University of California, Berkeley
Track: Autophagy and Lysosomal Degradation Pathways

Monday
Short Talk: Multiple Chaperones Function as Autophagic Receptors for Aggreghagy
07:45pm - 08:00pm Eastern - June 7, 2021 | Room: V200 - Ronney
Liang Ge, PhD, Tsinghua University
Track: Autophagy and Lysosomal Degradation Pathways

Signaling Degradation
10:00am - 01:00pm Eastern - June 8, 2021 | Room: Multi-Room Split Session
Brenda A. Schulman, PhD, Co-Chair, Max Planck Institute of Biochemistry; Raymond J. Deshaies, PhD, Co-Chair, Amgen, Inc.
Track: Signaling Degradation

Tuesday
Cullin-RING E3 Ligase Specificity
10:00am - 10:25am Eastern - June 8, 2021 | Room: V100 - Atticus
Brenda A. Schulman, PhD, Max Planck Institute of Biochemistry
Track: Signaling Degradation

Tuesday
Reprogramming E3-Ligases using Small Molecules
10:25am - 10:50am Eastern - June 8, 2021 | Room: V100 - Atticus
Track: Signaling Degradation

Tuesday
Targeting Ubiquitin Signaling in Infectious Diseases
10:50am - 11:15am Eastern - June 8, 2021 | Room: V100 - Atticus
Ivan Dikic, MD, PhD, Goethe University Medical School
Track: Signaling Degradation

Tuesday
Proteomics of Ubiquitin Signaling
11:15am - 11:40am Eastern - June 8, 2021 | Room: V100 - Atticus
J. Wade Harper, PhD, Harvard Medical School
Track: Signaling Degradation

Tuesday
Co-opting the Ubiquitin System for Therapeutic Benefit
11:55am - 12:20pm Eastern - June 8, 2021 | Room: V200 - Ronney
Ingrid E. Wertz, MD, PhD, Bristol Myers Squibb
Track: Signaling Degradation

Tuesday
Diversion of E3 Ligase Function by Small Molecules
12:20pm - 12:45pm Eastern - June 8, 2021 | Room: V200 - Ronney
Nicolas H. Thomä, PhD, Friedrich Miescher Institute for Biomedical Research
Track: Signaling Degradation

Tuesday
Short Talk: Functional Genomic Dissection of the Mechanisms of Molecular Glue Degraders
12:45pm - 01:00pm Eastern - June 8, 2021 | Room: V200 - Ronney
Mikolaj Slabicki, PhD, Dana-Farber Cancer Institute
Track: Signaling Degradation

Tuesday
Career Roundtable
02:00pm - 03:00pm Eastern - June 8, 2021
Kylie J. Walters, PhD, NCI, National Institutes of Health; Ingrid E. Wertz, MD, PhD, Bristol Myers Squibb; Judith Frydman, PhD, Stanford University
Track: Keystone Symposia Roundtables

Proteostasis and Proteome Remodeling
05:00pm - 08:10pm Eastern - June 8, 2021 | Room: Multi-Room Split Session
Judith Frydman, PhD, Co-Chair, Stanford University; Della David, PhD, Co-Chair, Eberhard Karls Universität Tübingen
Track: Proteostasis and Proteome Remodeling

Tuesday
Interplay between Chaperones and Degradation Machineries
05:00pm - 05:25pm Eastern - June 8, 2021 | Room: V100 - Atticus
Judith Frydman, PhD, Stanford University
Track: Proteostasis and Proteome Remodeling

Tuesday
Protein Degradation in Response to Reactive Oxygens
05:25pm - 05:50pm Eastern - June 8, 2021 | Room: V100 - Atticus
Ursula Jakob, PhD, University of Michigan
Track: Proteostasis and Proteome Remodeling

Tuesday
Mechanisms to Prevent Age-Dependent Protein Aggregation
05:50pm - 06:15pm Eastern - June 8, 2021 | Room: V100 - Atticus
Della David, PhD, Eberhard Karls Universität Tübingen
Track: Proteostasis and Proteome Remodeling

Tuesday
Tuning Translation with Ubiquitin
06:15pm - 06:40pm Eastern - June 8, 2021 | Room: V100 - Atticus
Eric J. Bennett, PhD, University of California, San Diego
Track: Proteostasis and Proteome Remodeling

Tuesday
Targeted Protein Degradation through the Endosome/Lysosome Pathway
06:50pm - 07:15pm Eastern - June 8, 2021 | Room: V200 - Ronney
Carolyn R. Bertozzi, PhD, Stanford University
Track: Proteostasis and Proteome Remodeling

Tuesday
Short Talk: Quality Control of Mistargeted Membrane Proteins: Ubiquitin-Mediated Sorting to the Lysosome for Degradation
07:15pm - 07:30pm Eastern - June 8, 2021 | Room: V200 - Ronney
Richa Sardana, PhD, Cornell University
Track: Proteostasis and Proteome Remodeling

Tuesday
Short Talk: Quantitative Proteomics Reveals the Selectivity of Ubiquitin-Binding Autophagy Receptors in the Turnover of Damaged Lysosomes by Lysophagy
07:30pm - 07:45pm Eastern - June 8, 2021 | Room: V200 - Ronney
Vinay Verghese Eapen, PhD, Harvard Medical School
Track: Proteostasis and Proteome Remodeling

Tuesday
Short Talk: Hsp90-Mediated Regulation of DYRK3 Couples Stress Granule Disassembly to Stress Adaptation and Cell Growth: Implications for Amyotrophic Lateral Sclerosis
07:45pm - 08:00pm Eastern - June 8, 2021 | Room: V200 - Ronney
Serena Carra, PhD, University of Modena and Reggio Emilia
Track: Proteostasis and Proteome Remodeling

Tuesday
Closing Remarks
08:00pm - 08:10pm Eastern - June 8, 2021
Track: Proteostasis and Proteome Remodeling