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Joint meeting with Neurodegenerative Diseases: Genes, Mechanisms and Therapeutics

NeuroImmune Interactions in Health and Disease

June 7-9, 2021 | 9:00AM EDT | 1:00PM UTC | 3:00PM CEST*
*Program is in development and subject to change



Joint Meetings

Your registration provides you with access to both the “Neurodegenerative Diseases: Genes, Mechanisms and Therapeutics” and “NeuroImmune Interactions in Health and Disease” eSymposia events. Use the link below to explore the joint meeting features, including live plenary sessions, On Demand talks, posters, forums, job postings, 1:1 Connect appointments and more. This joint meeting access is designed to facilitate cross-disciplinary insights and collaborations to drive both fields in exciting new directions!

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[Joint Session] Welcoming Remarks and Keynote Address
09:00am - 10:10am Eastern - June 7, 2021
Eric J. Huang, MD, PhD, Co-Chair, University of California, San Francisco; Beth Stevens, PhD, Co-Chair, Boston Children's Hospital, Harvard Medical School
Track: [Joint Session] Welcoming Remarks and Keynote Address

Monday
Manipulating Immune Trafficking In and Out of the CNS
09:00am - 09:40am Eastern - June 7, 2021
Akiko Iwasaki, PhD, Yale University School of Medicine
Track: [Joint Session] Welcoming Remarks and Keynote Address

Monday
Exploiting Dynamic Enhancer Landscapes to Infer Pathogenic Mechanisms in Neurodegenerative Diseases
09:40am - 10:10am Eastern - June 7, 2021
Christopher K. Glass, MD, PhD, University of California, San Diego
Track: [Joint Session] Welcoming Remarks and Keynote Address

[Joint Session] Disease Mechanisms and Therapeutic Targets
10:10am - 01:00pm Eastern - June 7, 2021
Joseph W. Lewcock, PhD, Co-Chair, Denali Therapeutics; Kate Monroe, PhD, Co-Chair, Denali Therapeutics
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Antisense Oligonucleotides for the Treatment of Neurological Diseases
10:10am - 10:35am Eastern - June 7, 2021 | Room: V300 - Ian
Holly Kordasiewicz, PhD, Ionis Pharmaceuticals
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Therapeutic Strategies for the Treatment of Neurodegenerative Disease Based on Human Genetics
10:35am - 11:00am Eastern - June 7, 2021 | Room: V300 - Ian
Joseph W. Lewcock, PhD, Denali Therapeutics
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Enhancing Microglia Function with ATV:TREM2
11:00am - 11:25am Eastern - June 7, 2021 | Room: V300 - Ian
Kate Monroe, PhD, Denali Therapeutics
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Neuroimmunological Target Considerations - To Be or Not To Be in the Brain
11:50am - 12:15pm Eastern - June 7, 2021
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Short Talk: TREM2-Independent Neuroprotection Mediated by Monocyte-Derived Macrophages in a Mouse Model of Alzheimer’s Disease
12:15pm - 12:30pm Eastern - June 7, 2021
Raz Dvir Szternfeld, MS, Weizmann Institute of Science
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Short Talk: Myokine Irisin Is a Critical Regulator of Cognitive Function
12:30pm - 12:45pm Eastern - June 7, 2021
Christiane D. Wrann, PhD, Massachusetts General Hospital
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Monday
Short Talk: Highly Conserved Glial Pathology and Human-Specific Neuronal Pathology Promote Neurodegeneration in FTLD-GRN
12:45pm - 01:00pm Eastern - June 7, 2021
Elise Marsan, PhD, University of California, San Francisco
Track: [Joint Session] Disease Mechanisms and Therapeutic Targets

Mapping Immune Cell States in Health and Disease
01:00pm - 02:45pm Eastern - June 7, 2021 | Room: Multi-Room Split Session
Francisco J. Quintana, PhD, Co-Chair, Harvard Medical School and the Broad Institute of MIT and Harvard; Beth Stevens, PhD, Co-Chair, Boston Children's Hospital, Harvard Medical School
Track: Mapping Immune Cell States in Health and Disease

Monday
Mapping Microglia State to Function in Health and Disease
01:00pm - 01:25pm Eastern - June 7, 2021 | Room: V300 - Ian
Beth Stevens, PhD, Boston Children's Hospital, Harvard Medical School
Track: Mapping Immune Cell States in Health and Disease

Monday
The T Cell-Myeloid Axis in Neuroinflammation
01:25pm - 01:50pm Eastern - June 7, 2021 | Room: V300 - Ian
Burkhard Becher, PhD, University of Zurich
Track: Mapping Immune Cell States in Health and Disease

Monday
Redefining Astrocytes States in Health and Disease
01:50pm - 02:15pm Eastern - June 7, 2021 | Room: V300 - Ian
Shane Antony Liddelow, PhD, New York University Langone Medical Center
Track: Mapping Immune Cell States in Health and Disease

Monday
Short Talk: Identification of a Novel Astrocyte Toxic Factor
02:15pm - 02:30pm Eastern - June 7, 2021 | Room: V300 - Ian
Kevin Guttenplan, PhD, Oregon Health & Science University
Track: Mapping Immune Cell States in Health and Disease

Monday
Short Talk: Brain Macrophage Transplantation for Research and Therapy Development
02:30pm - 02:45pm Eastern - June 7, 2021 | Room: V300 - Ian
Frederick Bennett, MD, University of Pennsylvania
Track: Mapping Immune Cell States in Health and Disease

Neuroimmune Regulation of Sleep and Brain States
09:00am - 10:30am Eastern - June 8, 2021 | Room: Multi-Room Split Session
Jonathan Kipnis, PhD, Co-Chair, Washington University School of Medicine; Maria Lehtinen, PhD, Co-Chair, Harvard Medical School
Track: Neuroimmune Regulation of Sleep and Brain States

Tuesday
Sleep Regulation and Disease Roles of the Glymphatic System
09:00am - 09:25am Eastern - June 8, 2021
Maiken Nedergaard, MD, PhD, University of Rochester
Track: Neuroimmune Regulation of Sleep and Brain States

Tuesday
APOE, Innate Immunity, and Neurodegeneration
09:25am - 09:50am Eastern - June 8, 2021
David M. Holtzman, MD, Washington University
Track: Neuroimmune Regulation of Sleep and Brain States

Tuesday
ILCs and Sleep
09:50am - 10:15am Eastern - June 8, 2021
Marco Colonna, MD, Washington University School of Medicine
Track: Neuroimmune Regulation of Sleep and Brain States

Tuesday
[NOT AVAILABLE ON DEMAND] Short Talk: Aging-Associated Myelin Dysfunction Drives Amyloid Deposition in Alzheimer’s Disease
10:15am - 10:30am Eastern - June 8, 2021
Constanze Martha Depp, MS, Max Planck Institute for Experimental Medicine
Track: Neuroimmune Regulation of Sleep and Brain States

NeuroImmune Crosstalk at Brain Borders
10:30am - 01:10pm Eastern - June 8, 2021 | Room: Multi-Room Split Session
Jonathan Kipnis, PhD, Co-Chair, Washington University School of Medicine; Maria Lehtinen, PhD, Co-Chair, Harvard Medical School
Track: NeuroImmune Crosstalk at Brain Borders

Tuesday
Lymphatic System Function and Dysfunction
10:30am - 10:55am Eastern - June 8, 2021
Jonathan Kipnis, PhD, Washington University School of Medicine
Track: NeuroImmune Crosstalk at Brain Borders

Tuesday
Boosting Immunity to Combat Alzheimer's Disease
10:55am - 11:20am Eastern - June 8, 2021
Michal Schwartz, PhD, Weizmann Institute of Science
Track: NeuroImmune Crosstalk at Brain Borders

Tuesday
Imaging and Probing Choroid Plexus Influence on Brain Development and Function
11:20am - 11:45am Eastern - June 8, 2021
Maria Lehtinen, PhD, Harvard Medical School
Track: NeuroImmune Crosstalk at Brain Borders

Tuesday
Control of Blood Brain Barrier Development, Function and Dysfunction
12:15pm - 12:40pm Eastern - June 8, 2021
Richard Daneman, PhD, University of California, San Diego
Track: NeuroImmune Crosstalk at Brain Borders

Tuesday
Short Talk: The Meninges Function as a Niche for B Lymphopoiesis in Early Life
12:40pm - 12:55pm Eastern - June 8, 2021
Alec Walker, BS, Boston Children's Hospital
Track: NeuroImmune Crosstalk at Brain Borders

Tuesday
Short Talk: Skull and Vertebral Bone Marrow Are Myeloid Cell Reservoirs for the Meninges and CNS Parenchyma
12:55pm - 01:10pm Eastern - June 8, 2021
Justin Rustenhoven, PhD, Washington University in St Louis
Track: NeuroImmune Crosstalk at Brain Borders

Immune Mechanisms of Synapse Function and Dysfunction
01:10pm - 02:30pm Eastern - June 8, 2021 | Room: Multi-Room Split Session
Beth Stevens, PhD, Co-Chair, Boston Children's Hospital, Harvard Medical School; Jonathan Kipnis, PhD, Co-Chair, Washington University School of Medicine
Track: Immune Mechanisms of Synapse Function and Dysfunction

Tuesday
Neural-Immune Crosstalk at the Synapse
01:10pm - 01:35pm Eastern - June 8, 2021
Dorothy Schafer, PhD, University of Massachusetts Medical School
Track: Immune Mechanisms of Synapse Function and Dysfunction

Tuesday
Autoimmune Mechanisms of Cognitive Dysfunction
01:35pm - 02:00pm Eastern - June 8, 2021
Betty Diamond, MD, Feinstein Institute for Medical Research
Track: Immune Mechanisms of Synapse Function and Dysfunction

Tuesday
Short Talk: Synaptic Proteomics in an AD Mouse Model Reveals Complement-Dependent Synapse Elimination by Astrocytes
02:00pm - 02:15pm Eastern - June 8, 2021
Borislav Dejanovic, PhD, Broad Institute
Track: Immune Mechanisms of Synapse Function and Dysfunction

Tuesday
Short Talk: Novel Microglia-Mediated Mechanisms Underlying Synaptic Loss and Cognitive Impairment after Traumatic Brain Injury
02:15pm - 02:30pm Eastern - June 8, 2021
Susanna Rosi, PhD, University of California, San Francisco
Track: Immune Mechanisms of Synapse Function and Dysfunction

Tuesday
[Joint Session] Meet the Editors Roundtable
03:30pm - 04:30pm Eastern - June 8, 2021
Swapnika Ramu, PhD, Cell Press; Gabriel A. Gasque, PhD, PLOS (Public Library of Science); Sophie Morgan, PhD, Nature Communications; Tim Spencer, PhD, Journal of Cell Biology (JCB)
Track: Keystone Symposia Roundtables

Immune Regulation of Brain Development and Behavior
09:00am - 11:00am Eastern - June 9, 2021 | Room: Multi-Room Split Session
Dorothy Schafer, PhD, Co-Chair, University of Massachusetts Medical School; Burkhard Becher, PhD, Co-Chair, University of Zurich
Track: Immune Regulation of Brain Development and Behavior

Wednesday
The Impact of Social Stress on Immune Cell Trafficking and Neurobehavior
09:00am - 09:25am Eastern - June 9, 2021 | Room: V100 - Atticus
Jonathan P. Godbout, PhD, Ohio State University
Track: Immune Regulation of Brain Development and Behavior

Wednesday
Microglia and the Crossroads of Cortical Wiring and Environmental Signals
09:25am - 09:50am Eastern - June 9, 2021 | Room: V100 - Atticus
Track: Immune Regulation of Brain Development and Behavior

Wednesday
Neuroimmune Interactions Shaping Social Behavior
09:50am - 10:15am Eastern - June 9, 2021 | Room: V100 - Atticus
Gloria Choi, PhD, Massachusetts Institute of Technology
Track: Immune Regulation of Brain Development and Behavior

Wednesday
Short Talk: Pyramidal Neuron Subtype Diversity Governs Microglia States in the Neocortex
10:15am - 10:30am Eastern - June 9, 2021 | Room: V100 - Atticus
Jeffrey Stogsdill, PhD, Harvard University
Track: Immune Regulation of Brain Development and Behavior

Wednesday
Short Talk: Role of Microglia-Vasculature Interaction in Angiogenesis and Germinal Matrix hemorrhage in the Prenatal Brain
10:30am - 10:45am Eastern - June 9, 2021 | Room: V100 - Atticus
Jiapei Chen, BS, University of California, San Francisco
Track: Immune Regulation of Brain Development and Behavior

Wednesday
Short Talk: The Role of Virus-Like Intercellular Communication in Neuroinflammation
10:45am - 11:00am Eastern - June 9, 2021 | Room: V100 - Atticus
Jason Shepherd, PhD, University of Utah
Track: Immune Regulation of Brain Development and Behavior

T Cell Brain Communication
11:20am - 12:55pm Eastern - June 9, 2021 | Room: Multi-Room Split Session
Dorothy Schafer, PhD, Co-Chair, University of Massachusetts Medical School; Burkhard Becher, PhD, Co-Chair, University of Zurich
Track: T Cell Brain Communication

Wednesday
T Cell-Neural Interactions in Health and Disease
11:20am - 11:45am Eastern - June 9, 2021 | Room: V200 - Craig
Anthony J. Filiano, PhD, Duke University
Track: T Cell Brain Communication

Wednesday
Immune Regulatory Processes within the Central Nervous System
11:45am - 12:10pm Eastern - June 9, 2021 | Room: V200 - Craig
Frauke Zipp, MD, Johannes-Gutenberg-Universität Mainz
Track: T Cell Brain Communication

Wednesday
Short Talk: Neutrophil Trafficking to Brain Driven by Peripheral Inflammatory Macrophages Modulates CNS Control of Behavior
12:10pm - 12:25pm Eastern - June 9, 2021 | Room: V200 - Craig
Celia E. Shiau, PhD, University of North Carolina at Chapel Hill
Track: T Cell Brain Communication

Wednesday
Short Talk: Direct Modulation of Neuronal Firing Patterns and Local Networks by Invading Lymphocytes
12:25pm - 12:40pm Eastern - June 9, 2021 | Room: V200 - Craig
Stefan Bittner, MD, University Medical Center Mainz
Track: T Cell Brain Communication

Wednesday
Short Talk: Microglia Engulf Myelin during Immune-Mediated Cortical Demyelination
12:40pm - 12:55pm Eastern - June 9, 2021 | Room: V200 - Craig
Ethan G. Hughes, PhD, University of Colorado Anschutz Medical Campus
Track: T Cell Brain Communication

Impact of Peripheral Signals and the Gut Brain Axis
12:55pm - 03:30pm Eastern - June 9, 2021 | Room: Multi-Room Split Session
Burkhard Becher, PhD, Co-Chair, University of Zurich; Elaine Y. Hsiao, PhD, Co-Chair, University of California, Los Angeles
Track: Impact of Peripheral Signals and the Gut Brain Axis

Wednesday
Neuronal Regulation of Innate Immune Cells
12:55pm - 01:20pm Eastern - June 9, 2021 | Room: V100 - Atticus
Daniel Mucida, PhD, Rockefeller University
Track: Impact of Peripheral Signals and the Gut Brain Axis

Wednesday
The Microbiome as a Modifier of Environmental Risk for Cognitive Impairment
01:20pm - 01:45pm Eastern - June 9, 2021 | Room: V100 - Atticus
Elaine Y. Hsiao, PhD, University of California, Los Angeles
Track: Impact of Peripheral Signals and the Gut Brain Axis

Wednesday
Neuronal Regulation of Innate Lymphoid Cells
01:45pm - 02:10pm Eastern - June 9, 2021 | Room: V100 - Atticus
Henrique Veiga-Fernandes, PhD, Champalimaud Research
Track: Impact of Peripheral Signals and the Gut Brain Axis

Wednesday
Neuroimmune Regulation of Itch
02:10pm - 02:35pm Eastern - June 9, 2021 | Room: V100 - Atticus
Brian Kim, MD, Washington University School of Medicine
Track: Impact of Peripheral Signals and the Gut Brain Axis

Wednesday
Microbial Regulation of Astrocyte Responses
02:35pm - 03:00pm Eastern - June 9, 2021 | Room: V100 - Atticus
Francisco J. Quintana, PhD, Harvard Medical School and the Broad Institute of MIT and Harvard
Track: Impact of Peripheral Signals and the Gut Brain Axis

Wednesday
Short Talk: Mechanisms of Th17 Cell-Mediated Microglial Activation and BBB Dysfunction in Post-Infectious Basal Ganglia Encephalitis
03:00pm - 03:15pm Eastern - June 9, 2021 | Room: V100 - Atticus
Charlotte R. Wayne, MS, Columbia University Irving Medical Center
Track: Impact of Peripheral Signals and the Gut Brain Axis

Wednesday
Short Talk: Colitis Disrupts Inflammatory Gene Networks and Nigrostriatal Integrity in the Brain and LRRK2 G2019S Mutant Mice Display Enhanced Vulnerability
03:15pm - 03:30pm Eastern - June 9, 2021 | Room: V100 - Atticus
Malu G. Tansey, PhD, University of Florida
Track: Impact of Peripheral Signals and the Gut Brain Axis

Wednesday
Closing Remarks
03:30pm - 03:40pm Eastern - June 9, 2021
Track: Impact of Peripheral Signals and the Gut Brain Axis