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Targeted Protein Degradation: From Small Molecules to Complex Organelles

June 7-8, 2021 | 10:00AM EDT | 2:00PM UTC | 4:00PM CEST*
*Program is in development and subject to change



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The live portion of this conference has concluded and all presentations are now available for purchase on demand. Registrants to the live event may access this content anytime for up to 9 months following the event.


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Targeted protein degradation plays a critical role in regulating nearly all cellular functions, and as such, its dysfunction is associated with severe pathologies including diseases like cancer, neurodegeneration and age-associated diseases. Therefore, fundamental insights into protein clearance pathways might be harnessed for therapeutic applications against a wide range of diseases. While much progress has been made in revealing mechanisms of autophagy and the ubiquitin-proteasome system, the major protein degradation pathways defined thus far, these fields continue to remain isolated from each other despite the interconnection of these processes. This separation is now leading to an urgent need to discuss the interplay of these pathways at the molecular and cellular levels to integrate our understanding of these processes and how they contribute to disease pathology. This conference will bring together researchers from these different fields, who do not typically interact, to build a holistic and integrated vision of protein degradation. Such an integrative conference highlighting the connections between the different branches of protein degradation research does not yet exist, so this Keystone Symposia conference will be the first of its kind to reshape how these fields interact and collaborate to yield transformative insights into both basic science and disease processes.

Topics of discussion will include:

  1. Substrate recognition and processing by energy-dependent proteases, autophagy and lysosomal pathways
  2. Signals targeting proteins to distinct degradation pathways
  3. Interplay between proteolytic systems and chaperone pathways
  4. Reprogramming degradation with small molecules for therapeutic applications
  5. Degradation programs driving global proteome remodeling

Attendees will be exposed to novel perspectives, as well as methods, techniques and approaches, that will advance research within their field, and across the many different components in the protein degradation landscape.

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Pricing:

Regular Registration Rate: $275 USD
Student Registration Rate: $150 USD

Deadlines:

Abstract Submission:
‣ For Short Talk Consideration: Passed
‣ For Poster Booth: Passed
ePoster / SciTalk Submission: Passed
Financial Aid Application: Passed

*Abstract submission is required in order to submit an ePoster and/or Scitalk

#VKSPDegradation21




Program Details



Speaking at this eSymposia



Eric J. Bennett

University of California, San Diego, USA


Carolyn R. Bertozzi

Stanford University, USA


Tim Clausen

Research Institute of Molecular Pathology, IMP, Austria


Della David

Eberhard Karls Universität Tübingen, Germanyy


Raymond J. Deshaies

Amgen, Inc., USA


Ivan Dikic

Goethe University Medical School, Germany



Daniel J. Finley

Harvard University, USA


Judith Frydman

Stanford University, USA


Jonathan Goodwin

Casma Therapeutics, USA


Malene Hansen

Sanford Burnham Prebys Medical Discovery Institute, USA


J. Wade Harper

Harvard Medical School, USA


Ursula Jakob

University of Michigan, USA


Sascha Martens

University of Vienna, Austria


Brenda A. Schulman

Max Planck Institute of Biochemistry, Germany


Michal Sharon

Weizmann Institute of Science, Israel


Anne Simonsen

University of Oslo, Norway


Nicolas H. Thomä

Friedrich Miescher Institute for Biomedical Research, Switzerland


Kylie J. Walters

NCI, National Institutes of Health, USA


Eilika Weber-Ban

ETH Zürich, Switzerland


Ingrid E. Wertz

Genentech, Inc., USA


Hong Zhang

Chinese Academy of Sciences, China






Sponsors


 

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Additional Support



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Funding for this conference was made possible (in part) by 1R13TR003730-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.




Media-in-Kind Support


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Additional in-Kind Support



 

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Funding for this conference was made possible (in part) by Grant No. 1R13CA254442-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.





#ScienceMustGoOn


This new virtual meeting format came out of difficult circumstances, but your commitment to scientific progress is what inspired us to launch Keystone eSymposia. In these virtual meetings, we are capturing the same innovative essence of our in-person meetings that you've all created as a scientific community. Here, Debbie Johnson, our CEO, explains how we're going to do that.







The views expressed in this eSymposia are those of the participants and not necessarily of the participants’ organizations or of Keystone Symposia.






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