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Targeted Protein Degradation: From Small Molecules to Complex Organelles

June 7-8, 2021 | 10:00AM EDT | 2:00PM UTC | 4:00PM CEST*
*Program is in development and subject to change


The live portion of this conference has concluded and all presentations are now available for purchase on demand. Registrants to the live event may access this content anytime for up to 9 months following the event.

 Free Access to On Demand Content to Scientists from Low-and Middle-Income Countries

Keystone Symposia welcomes the global scientific community and aims to connect researchers within and across disciplines to accelerate the advancement of biomedical and life sciences. This form may be used for scientists from low- and middle-income countries of all career stages to determine eligibility and request free access to scientific content presented during recent eSymposia events. If eligible, you will be sent an access code for the On Demand content of the eSymposia event(s) of interest.

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Targeted protein degradation plays a critical role in regulating nearly all cellular functions, and as such, its dysfunction is associated with severe pathologies including diseases like cancer, neurodegeneration and age-associated diseases. Therefore, fundamental insights into protein clearance pathways might be harnessed for therapeutic applications against a wide range of diseases. While much progress has been made in revealing mechanisms of autophagy and the ubiquitin-proteasome system, the major protein degradation pathways defined thus far, these fields continue to remain isolated from each other despite the interconnection of these processes. This separation is now leading to an urgent need to discuss the interplay of these pathways at the molecular and cellular levels to integrate our understanding of these processes and how they contribute to disease pathology. This conference will bring together researchers from these different fields, who do not typically interact, to build a holistic and integrated vision of protein degradation. Such an integrative conference highlighting the connections between the different branches of protein degradation research does not yet exist, so this Keystone Symposia conference will be the first of its kind to reshape how these fields interact and collaborate to yield transformative insights into both basic science and disease processes.

Topics of discussion will include:

  1. Substrate recognition and processing by energy-dependent proteases, autophagy and lysosomal pathways
  2. Signals targeting proteins to distinct degradation pathways
  3. Interplay between proteolytic systems and chaperone pathways
  4. Reprogramming degradation with small molecules for therapeutic applications
  5. Degradation programs driving global proteome remodeling

Attendees will be exposed to novel perspectives, as well as methods, techniques and approaches, that will advance research within their field, and across the many different components in the protein degradation landscape.


Regular Registration Rate: $275 USD
Student Registration Rate: $150 USD


Abstract Submission:
‣ For Short Talk Consideration: April 26, 2021
‣ For Poster Booth: May 24, 2021
ePoster / SciTalk Submission: May 27, 2021
Financial Aid Application: May 24, 2021

*Please note, abstract submission is required
in order to submit an ePoster and/or Scitalk


Financial Aid Opportunities

Graduate students and postdoctoral fellows, as well as individuals from low- and middle- income countries (all career stages) working in science and medicine related fields, are eligible to apply for a FREE registration code.

Find out more about financial aid opportunities here!

Call For Abstracts

Showcase your work to global audiences on the eSymposia platform!

Submit your abstract for the opportunity to be selected for a short talk presentation alongside field leaders on the meeting program! See Abstract Deadline for Short Talk Consideration

ePoster presenters will be provided with their own dedicated page on the event website to display their work in multiple formats and interact with meeting participants. ePoster features include:

  • Abstract
  • Poster PDF for download
  • SciTalk – up to 5 minute video presentation, available on-demand
  • Live chat function to answer audience questions in real-time
  • Contact information for private follow-up discussion

To submit your work for an ePoster presentation, and to be considered for short talk selection, go to the “Submit an Abstract” tab on the event homepage.

Program Details

Speaking at this eSymposia

Iannis Aifantis

New York University School of Medicine, USA

Ido Amit

Weizmann Institute, Israel

Fernando D. Camargo

Boston Children's Hospital, USA

Benjamin L. Ebert

Dana-Farber Cancer Institute, USA

Patricia Ernst

University of Colorado Anschutz Medical Center, USA

E. Camilla Forsberg

University of California, Santa Cruz, USA

Margaret A. Goodell

Baylor College of Medicine, USA

H. Leighton Grimes

Cincinnati Children's Hospital Medical Center, USA

Atsushi Iwama

University of Tokyo, Japan

Catriona H.M. Jamieson

University of California, San Diego, USA

Michael G. Kharas

Memorial Sloan Kettering Cancer Center, USA

Katherine Y. King

Baylor College of Medicine, USA

Ross L. Levine

Memorial Sloan Kettering Cancer Center, USA

Cristina Lo Celso

Imperial College London, UK

Ravi Majeti

Stanford University, USA

Shannon L. McKinney-Freeman

St. Jude Children's Research Hospital, USA

Hanna K.A. Mikkola

University of California, Los Angeles, USA

Sean J. Morrison

University of Texas Southwestern Medical Center, USA

Timm Schroeder

ETH Zürich, Switzerland

Daniel Starczynowski

Cincinnati Children's Hospital Medical Center, USA

Jennifer Trowbridge

The Jackson Laboratory, USA

Kate Yen

Auron Therapeutics, USA

Leonard I. Zon

HHMI/Boston Children's Hospital, USA

More program details will be available soon.

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Additional Support




Funding for this conference was made possible (in part) by Grant No. 1R13CA254442-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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This new virtual meeting format came out of difficult circumstances, but your commitment to scientific progress is what inspired us to launch Keystone eSymposia. In these virtual meetings, we are capturing the same innovative essence of our in-person meetings that you've all created as a scientific community. Here, Debbie Johnson, our CEO, explains how we're going to do that.

The views expressed in this eSymposia are those of the participants and not necessarily of the participants’ organizations or of Keystone Symposia.

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