Dr. Jiangbin Ye received his Ph.D in the Cancer Biology Program at University of Pennsylvania on 2010. His research in Dr. Constantinous Koumenis’ lab uncovered the critical role of GCN2-ATF4 pathway in sensing amino acid depletion and maintaining metabolic homeostasis in tumor cells (EMBO J. 2010).
During his graduate studies, Dr. Ye developed a strong interest in how cancer cells respond to nutrient signals and how metabolic alterations impact tumor progression. Intrigued by the emerging theory that cancer is a metabolic disease, he started the postdoctoral training in Dr. Craig Thompson’s lab at Memorial Sloan Kettering Cancer Center. Dr. discovered the unique role of serine and one-carbon unit metabolism in cancer cell proliferation, mitochondrial redox regulation, and survival upon oxidative stress (PNAS 2012, Nature 2014, Cancer Discovery 2014). His recent work also defined an important link between two major amino acid sensing mechanisms that regulate adaptation to fluctuating amino acid levels in the environment: Sestrin2 is a critical effector of GCN2 signaling that regulates amino acid homeostasis through mTORC1 suppression (Genes & Dev. 2015).
Dr. Ye initiated his independent research career at Stanford University, Department of Radiation Oncology as an Assistant Professor on 2016. His current research interests include: 1. The interconnection between metabolic reprograming, epigenetic regulations and cell differentiation in cancer. 2. How to target altered metabolic pathways in metastatic cancer. 3. Metabolomics profiling of patient samples to identify biomarkers for cancer early detection.