Han Brunner pursues the scientific understanding of the connections between clinical and molecular features of rare diseases, including applications to patient care. He has pioneered the discovery of a large number of disease genes and the application of cutting-edge genomic technologies (genomic microarrays, exome sequencing, and whole genome sequencing) to discover the causes of genetic diseases. Much of this work focuses on neurodevelopmental conditions such as intellectual disability and abnormal behavior.
Han Brunner studied medicine at the University of Groningen 1975-1984. He trained as a clinical geneticist at Nijmegen University and was board certified in Clinical Genetics in 1988. In 1998 he was appointed full professor and head of department at the Radboud University Medical Center. As of January 2014 he has a joint appointment in Nijmegen at the department of Human Genetics in Nijmegen and in Maastricht at the department of Clinical Genetics.