Age-dependent asymmetric apportioning of mitochondria during division determines cell fate

Explore related products in the following collection:

Age-dependent asymmetric apportioning of mitochondria during division determines cell fate
 
Julia Döhla1,2, Ana Amaral1, Ella Salminen2, Johanna I Englund2, Swetha Gopalakrishnan2, Nadia Gebert3, Alessandro Ori3, Pekka Katajisto1,2*
1Institute of Biotechnology, HiLIFE, University of Helsinki, Finland; 2Department of Biosciences and Nutrition, Karolinska Institute, Sweden; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany
*Corresponding Author (pekka.katajisto@ki.se)
 
The maintenance of tissue renewal requires a balance between self-renewal and differentiation that can be achieved by asymmetric cell divisions. To ensure homeostasis throughout the lifespan, asymmetric divisions must be tightly regulated but it remains unknown which early decision mechanisms determine the fate of adult stem cells during such divisions. We have discovered age-dependent apportioning of mitochondria during asymmetric divisions as a potential mechanism guiding fates of the daughter cells. Stem-like human mammary epithelial cells (HMECs)1 apportion old mitochondria selectively to the differentiating daughter cell, while progeny omitting old mitochondria retains stem-like properties2. In this work we have characterised how the functional characteristics of the inherited mitochondria determine metabolic and functional properties of the daughter cells. Asymmetric apportioning of old mitochondria may therefore functionally contribute to the maintenance of a functional stem cell pool, and have important implications for the regenerative capacity of stem cells.
 
References (optional)
1. Chaffer, C. L. et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc. Natl. Acad. Sci. U. S. A. 108, 7950-7955 (2011).
 
2. Katajisto, P. et al. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. 348(6232): 340-3 (2015).
 
 
· · ·

Related Products

Thumbnail for Vms1 is a release factor for the Ribosome Quality control Complex
Vms1 is a release factor for the Ribosome Quality control Complex
VMS1 IS A RELEASE FACTOR FOR THE RIBOSOME QUALITY CONTROL COMPLEX
Thumbnail for AT1 and AT2 receptors mediate opposing mitochondrial respiratory and glycolytic stress responses to mitochondrial angiotensin II in proximal tubule cells
AT1 and AT2 receptors mediate opposing mitochondrial respiratory and glycolytic stress responses to mitochondrial angiotensin II in proximal tubule cells
AT1 AND AT2 RECEPTORS MEDIATE OPPOSING MITOCHONDRIAL RESPIRATORY AND GLYCOLYTIC STRESS RESPONSES TO MITOCHONDRIAL ANGIOTENSIN II IN PROXIMAL TUBULE CELLS
Thumbnail for Identification of mitochondrial RNA granules assembly factors and regulators using an image-based siRNA screen
Identification of mitochondrial RNA granules assembly factors and regulators using an image-based siRNA screen
IDENTIFICATION OF MITOCHONDRIAL RNA GRANULES ASSEMBLY FACTORS AND REGULATORS USING AN IMAGE-BASED SIRNA SCREEN
Thumbnail for Novel Functions of Rab24 in Regulating Blood Glucose Homeostasis and Mitochondrial Activity in the Liver
Novel Functions of Rab24 in Regulating Blood Glucose Homeostasis and Mitochondrial Activity in the Liver
NOVEL FUNCTIONS OF RAB24 IN REGULATING BLOOD GLUCOSE HOMEOSTASIS AND MITOCHONDRIAL ACTIVITY IN THE LIVER

Copyright © 2025 Keystone Symposia
Powered by Conexiant DXP
Privacy Policy Update: We value your privacy and want you to understand how your information is being used. To make sure you have current and accurate information about this sites privacy practices please visit the privacy center by clicking here.