Precision Oncology: Translating Discovery to the Clinic
June 21-24, 2021 | 9:00AM EDT | 1:00PM UTC | 3:00PM CEST*
*Program is in development and subject to change
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Showing results 1 - 10 of 11
Monday, June 21, 2021
Welcoming Remarks and Keynote Address
9:00 AM - 9:40 AM EDT
Monday, June 21, 2021Chair
Klaus Hoeflich, PhD
Nested Bio
Welcoming Remarks and Keynote Address
Lineage Plasticity: Lessons from Prostate Cancer
9:00 AM - 9:40 AM EDT
Monday, June 21, 2021Speaker
Charles Sawyers, MD
Johns Hopkins University School of Medicine
Welcoming Remarks and Keynote Address
Clinical Genomics
9:40 AM - 10:55 AM EDT
Monday, June 21, 2021Co-Chairs
Scott Lowe, PhD
Memorial Sloan Kettering Cancer Center
Todd Golub, MD
Broad Institute
Clinical Genomics
Pre-Clinical Approaches to Cancer Precision Medicine
9:40 AM - 10:05 AM EDT
Monday, June 21, 2021Speaker
Todd Golub, MD
Broad Institute
Clinical Genomics
Leukemia Genomics
10:05 AM - 10:30 AM EDT
Monday, June 21, 2021Speaker
Elli Papaemmanuil, PhD
Memorial Sloan Kettering Cancer Center
Clinical Genomics
Personalized Genomic Testing in Pediatric Oncology
10:30 AM - 10:55 AM EDT
Monday, June 21, 2021Speaker
Jaclyn Biegel, PhD
Children's Hospital Los Angeles and Keck School of Medicine of USC
Clinical Genomics
Targeting Novel Mechanisms
11:15 AM - 1:00 PM EDT
Monday, June 21, 2021Co-Chairs
Todd Golub, MD
Broad Institute
Scott Lowe, PhD
Memorial Sloan Kettering Cancer Center
Targeting Novel Mechanisms
LKB1/STK11 Axis in Precision Immunotherapy
11:15 AM - 11:40 AM EDT
Monday, June 21, 2021Speaker
John Heymach, MD, PhD
University of Texas MD Anderson Cancer Center
Targeting Novel Mechanisms
Structural Basis for the Action of Clinical MEK Inhibitors at KSR-Bound MEK
11:40 AM - 12:05 PM EDT
Monday, June 21, 2021Speaker
Arvin Dar, PhD
Icahn School of Medicine at Mount Sinai
Targeting Novel Mechanisms
Non-Cell Autonomous Tumor Control via Senescence
12:05 PM - 12:30 PM EDT
Monday, June 21, 2021Speaker
Scott Lowe, PhD
Memorial Sloan Kettering Cancer Center
Targeting Novel Mechanisms
Short Talk: Eganelisib (IPI-549) Activity as a Macrophage Reprogramming Therapeutic Candidate in 1L Metastatic TNBC, 2L Metastatic Urothelial Cancer and Other Solid Tumors
12:30 PM - 12:45 PM EDT
Monday, June 21, 2021Speaker
Brian Schwartz, MD
Infinity Pharmaceuticals, Inc.
SciTalk
Targeting Novel Mechanisms
Short Talk: SCD1-Regulated Ferroptosis as a Novel Therapeutic Strategy in Non-Small Cell Lung Cancer
12:45 PM - 1:00 PM EDT
Monday, June 21, 2021Speaker
Triparna Sen, PhD
Memorial Sloan Kettering Cancer Center
Targeting Novel Mechanisms
Tuesday, June 22, 2021
Emerging Technologies I
9:00 AM - 11:10 AM EDT
Tuesday, June 22, 2021Co-Chairs
Alice Shaw, MD, PhD
Novartis Institutes for Biomedical Research, Inc.
Nicola Aceto, PhD
ETH Zürich
Emerging Technologies I
Harnessing Tumor Evolution and Immune Responses to Treat Lung Cancer
9:00 AM - 9:25 AM EDT
Tuesday, June 22, 2021Speaker
Valsamo Anagnostou, MD
Johns Hopkins University School of Medicine
Emerging Technologies I
Single Cell Genomics Technologies in the Clinic – Challenges and Opportunities
9:25 AM - 9:50 AM EDT
Tuesday, June 22, 2021Speaker
Gromoslaw Smolen, PhD
Celsius Therapeutics
Emerging Technologies I
Biology and Vulnerabilities of Circulating Tumor Cells
9:50 AM - 10:15 AM EDT
Tuesday, June 22, 2021Speaker
Nicola Aceto, PhD
ETH Zürich
Emerging Technologies I
Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Cancer
10:15 AM - 10:40 AM EDT
Tuesday, June 22, 2021Speaker
Cigall Kadoch, PhD
Dana-Farber Cancer Institute, Harvard Medical School
Emerging Technologies I
Short Talk: Nano-Targeted Kinase Inhibitor Treatment of KRAS Mutant Lung Cancer
10:40 AM - 10:55 AM EDT
Tuesday, June 22, 2021Speaker
Ramya Sridharan, BS
Weill Cornell Medical
Emerging Technologies I
Short Talk: A Metastasis Map of Human Cancer Cell Lines
10:55 AM - 11:10 AM EDT
Tuesday, June 22, 2021Speaker
Xin Jin, BS
Broad Institute of MIT and Harvard
Emerging Technologies I
Clinical Trials and Overcoming Resistance
11:20 AM - 1:00 PM EDT
Tuesday, June 22, 2021Co-Chairs
Nicola Aceto, PhD
ETH Zürich
Alice Shaw, MD, PhD
Novartis Institutes for Biomedical Research, Inc.
Clinical Trials and Overcoming Resistance
Resistance to Non-Small Cell Lung Cancer Therapies
11:20 AM - 11:45 AM EDT
Tuesday, June 22, 2021Speaker
Alice Shaw, MD, PhD
Novartis Institutes for Biomedical Research, Inc.
Clinical Trials and Overcoming Resistance
Targeted EGFR/HER2 Therapy to Overcome the Blood-Brain Barrier
11:45 AM - 12:10 PM EDT
Tuesday, June 22, 2021Speaker
Lori Friedman, PhD
ORIC Pharmaceuticals
Clinical Trials and Overcoming Resistance
Defining Mechanisms of Resistance to KRASG12C Inhibitors
12:10 PM - 12:35 PM EDT
Tuesday, June 22, 2021Speaker
Jessica Lin, MD
Massachusetts General Hospital
Clinical Trials and Overcoming Resistance
Mechanisms of Resistance to Endocrine Therapy and CDK4/6 Inhibitors in ER+ Breast Cancer
12:35 PM - 1:00 PM EDT
Tuesday, June 22, 2021Speaker
Nikhil Wagle, MD
Dana-Farber Cancer Institute
Clinical Trials and Overcoming Resistance
Meet the Editors Roundtable
2:00 PM - 3:00 PM EDT
Tuesday, June 22, 2021Speakers
Sarah Hamilton, PhD
Cell Reports Medicine
Miguel Foronda, PhD
Nature Cancer
Avital Lev, PhD
Cancer Discovery
Lise Roth, PhD
EMBO Press
Keystone Symposia Roundtables
Wednesday, June 23, 2021
Emerging Technologies II
9:00 AM - 10:55 AM EDT
Wednesday, June 23, 2021Co-Chairs
Jason Carroll, PhD
Cancer Research UK, University of Cambridge
Russell Jenkins, MD, PhD
Massachusetts General Hospital
Emerging Technologies II
Driving Precision Medicine through Clinical Computational Oncology
9:00 AM - 9:25 AM EDT
Wednesday, June 23, 2021Speaker
Priti Hegde, PhD
Foundation Medicine
Emerging Technologies II
Organotypic Modeling of Cancer and Immune Cell Dynamics
9:25 AM - 9:50 AM EDT
Wednesday, June 23, 2021Speaker
Russell Jenkins, MD, PhD
Massachusetts General Hospital
Emerging Technologies II
Inferring and Making Sense Out of Cancer Cell Phylogenies
9:50 AM - 10:15 AM EDT
Wednesday, June 23, 2021Speaker
Nir Yosef, PhD
University of California, Berkeley
Emerging Technologies II
Targeted Protein Degradation- A New Approach for Challenging Targets
10:15 AM - 10:40 AM EDT
Wednesday, June 23, 2021Speaker
Nathanael Gray, PhD
Stanford University
Emerging Technologies II
Short Talk: MLL-Menin Inhibition Reverses Pre-leukemic Progenitor Self-renewal in NPM1 Mutant AML
10:40 AM - 10:55 AM EDT
Wednesday, June 23, 2021Speaker
Hannah Uckelmann, PhD
Dana-Farber Cancer Institute
Emerging Technologies II
Targeting Gene Transcription
11:10 AM - 1:15 PM EDT
Wednesday, June 23, 2021Co-Chairs
Russell Jenkins, MD, PhD
Massachusetts General Hospital
Jason Carroll, PhD
Cancer Research UK, University of Cambridge
Targeting Gene Transcription
New Synthetic Lethal Interactions in Acute Myeloid Leukemia
11:10 AM - 11:35 AM EDT
Wednesday, June 23, 2021Speaker
Christopher Vakoc, MD, PhD
Cold Spring Harbor Laboratory
Targeting Gene Transcription
Proteomic Analysis of Chromatin Remodeling Complexes
11:35 AM - 12:00 PM EDT
Wednesday, June 23, 2021Speaker
Jason Carroll, PhD
Cancer Research UK, University of Cambridge
Targeting Gene Transcription
Using GEMMs to Identify Therapeutic Vulnerabilities in MYC-Driven Small Cell Lung Cancer
12:00 PM - 12:25 PM EDT
Wednesday, June 23, 2021Speaker
Trudy Oliver, PhD
Huntsman Cancer Institute
Targeting Gene Transcription
Targeting the MLL Complex to Control Gene Expression
12:25 PM - 12:50 PM EDT
Wednesday, June 23, 2021Speaker
Scott Armstrong, MD, PhD
Dana-Farber Cancer Institute
Targeting Gene Transcription
PRMT1: A Novel Dependency at the Nexus of RNA Metabolism and Cancer
12:50 PM - 1:15 PM EDT
Wednesday, June 23, 2021Speaker
Timothy Heffernan, PhD
MD Anderson Cancer Center
Targeting Gene Transcription
Thursday, June 24, 2021
Novel Therapeutics
9:00 AM - 11:10 AM EDT
Thursday, June 24, 2021Co-Chairs
Scott Lowe, PhD
Memorial Sloan Kettering Cancer Center
Klaus Hoeflich, PhD
Nested Bio
Novel Therapeutics
Mechanisms of Resistance to Combined Inhibition of RAS Signaling plus Autophagy in Pancreatic Cancer
9:00 AM - 9:25 AM EDT
Thursday, June 24, 2021Speaker
Martin McMahon, PhD
University of Utah School of Medicine
Novel Therapeutics
Targeting Protein Kinases in Cancer
9:25 AM - 9:50 AM EDT
Thursday, June 24, 2021Speaker
Klaus Hoeflich, PhD
Nested Bio
Novel Therapeutics
A General Allele-Specific Model for Understanding and Treating Tumors Driven by ERK-Activation
9:50 AM - 10:15 AM EDT
Thursday, June 24, 2021Speaker
Neal Rosen, MD, PhD
Memorial Sloan-Kettering Cancer Center
Novel Therapeutics
High Dose Vitamin C and Inactivation of DNA Repair Boost Cancer Immunotherapy
10:15 AM - 10:40 AM EDT
Thursday, June 24, 2021Speaker
Alberto Bardelli, PhD
University of Torino
Novel Therapeutics
Short Talk: Regulation of PTEN Translation by PI3K Signaling Maintains Pathway Homeostasis
10:40 AM - 10:55 AM EDT
Thursday, June 24, 2021Speaker
Radha Mukherjee, PhD
Memorial Sloan Kettering
Novel Therapeutics
Short Talk: Oncogenic CCNE1 Amplification Is Synthetic Lethal with PKMYT1 Kinase Inhibition
10:55 AM - 11:10 AM EDT
Thursday, June 24, 2021Speaker
Jordan Young, PhD
Repare Therapeutics, Canada
Novel Therapeutics
The Future of Precision Oncology
11:35 AM - 12:25 PM EDT
Thursday, June 24, 2021Co-Chairs
Klaus Hoeflich, PhD
Nested Bio
Scott Lowe, PhD
Memorial Sloan Kettering Cancer Center
The Future of Precision Oncology
Informing Patient Treatment with Clinicogenomic Data
11:35 AM - 12:00 PM EDT
Thursday, June 24, 2021Speaker
Elaine Mardis, PhD
Nationwide Children's Hospital
The Future of Precision Oncology
NCI’s Precision Medicines Initiatives
12:00 PM - 12:25 PM EDT
Thursday, June 24, 2021Speaker
Naoko Takebe, MD, PhD
NCI, National Institutes of Health
The Future of Precision Oncology
Closing Remarks
12:25 PM - 12:35 PM EDT
Thursday, June 24, 2021Organizers
Klaus Hoeflich, PhD
Nested Bio
Scott Lowe, PhD
Memorial Sloan Kettering Cancer Center
