The transition of cryo-electron microscopy (cryo-EM) from a technology that was previously a useful tool to analyze large macromolecular assemblies, to one that can now successfully tackle structure determination of a wide range of proteins and protein complexes of broad general interest has been transformative. The structures of an impressive number of proteins, small and large, sometimes with extensive conformational spread, have been successfully analyzed by cryo-EM, although the landscape of macromolecular entities that are still intractable to analysis by cryo-EM remains immense. This meeting aims to bring together leaders in this emerging field who are defining the new frontiers of cryo-EM and future leaders who are rapidly beginning to adopt this new discipline and will likely drive future innovations in the coming decades. Speakers selected from academia, government and industry will cover applications of cryo-EM technology to fundamental problems in biology with particular relevance to cancer, neuroscience, microbiology and cell signaling, and discuss advances in method developments that are at the forefront of the field.

This new virtual meeting format came out of difficult circumstances, but your commitment to scientific progress is what inspired us to launch Keystone eSymposia. In these virtual meetings, we are capturing the same innovative essence of our in-person meetings that you've all created as a scientific community. Here, Debbie Johnson, our CEO, explains how we're going to do that.