Zfp467 Plays a Key role in the Regulation of Thermogenesis in Adipocyte H. Liu1, PT. Le1, F. Gori2, R. Baron2 3, and CJ. Rosen1 1Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME 04074, USA 2Division of Bone and Mineral Research, Harvard School of Dental Medicine, Boston, MA 02115, USA 3Harvard Medical School, Department of Medicine and Endocrine Unit, Massachusetts General Hospital, Boston, 02115, USA Zinc finger proteins (ZFPs) are one of the largest classes of transcription factors in eukaryotic genomes. A small but increasing number of ZFPs have been associated with adipogenesis. Zinc finger protein 467 (Zfp467) was found to enhance adipogenic differentiation by upregulating Pparg. To further investigate the role of Zfp467 in adipose tissues, we generated Zfp467-/- mice. Zfp467-/- mice (-/-) were significantly smaller than Zfp467+/+ mice (+/+) due to both decreased fat mass and fat free mass (p=0.0002). Adipocyte gene expression markers in inguinal fat pads also showed a significant decrease in Leptin and Fabp4 in -/- compared to +/+ (p
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