Description

Tissue and Immune Cell Profiling of Healthy and Unhealthy, Lean and Obese Primates Alistaire D. Ruggiero1, Masha Block1, Matthew Davis2, Ravichandra Vemuri1, Darla D. DeStephanis1, Swapan K. Das2, Kylie Kavanagh1,3 1Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA 2Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA 3College of Health and Medicine, University of Tasmania, Hobart, AUS Background: More the 93 million people are obese and over 66 million suffer from metabolic syndrome (MetS) in the United States. However, between 5-40% of obese individuals do not suffer from metabolic abnormalities and over 10% of lean individuals do. As an endocrine organ, adipose tissue maintains energy equilibrium and regulates metabolism. We established that African green vervet monkeys (AGMs) demonstrate naturally occurring obesity and MetS without genetic manipulation or high-fat diet consumption. Here, we investigated differences in subcutaneous (SQ) adipose tissue (AT) transcription and circulating monocyte subtypes in AGMs classified as metabolically healthy lean (MHL), metabolically healthy obese (MHO), metabolically unhealthy lean (MUL), and metabolically unhealthy obese (MUO). Methods: A cohort of 44 age- and sex-matched AGMs were classified as MHL, MHO, MUL and MUO according to MetS criteria adjusted for nonhuman primates (waist circumference >40cm, HbA1c >6, fasting blood glucose >100 mg/dL, systolic blood pressure >135mmHg, diastolic blood pressure >85mmHg, triglycerides >125mg/dL, and HDL cholesterol

Speaker(s):

• Alistaire D. Ruggiero, Other, Wake Forest School of Medicine