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eSymposia | The Microbiome: From Mother to Child


Early development of the gut bacteriome and virome and their interactions


Jan 18, 2021 12:00am ‐ Jan 18, 2021 12:00am

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Early development of the gut bacteriome and virome and their interactions S. Garmaeva1, T. Sinha1, A. Gulyaeva1, L. Chen1, S. Jankipersadsing1, J. Dekens1,2, J. Spreckels1, S. Brushett1, M. Kruk1, R. Gacesa1,3, A. Vich Vila1,3, F. Kuipers4, J. Sikkema2, A. Kurilshikov1, S. Scherjon5, C. Wijmenga1, J. Fu1,4, A. Zhernakova1 1Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands; 2Center of Development and Innovation, University Medical Center Groningen, Groningen, The Netherlands; 3Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands; 4Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands; 5Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands. Background The human gut microbiome is mostly shaped during infancy and affects health in adulthood. Studies in other ecosystems have revealed the crucial role of bacteria's interaction with viruses in microbiome establishment. However, the role of viruses in the development of the gut ecosystem is underexplored. Aims and Methods We thus aimed to investigate the role of virome and bacterial strains in the early development of the gut ecosystem and its relationship with infant gut health. For this purpose, we use Lifelines-NEXT, a prospective ongoing birth cohort in the Northern Netherlands aimed to include 1500 newborns and their parents. In the Lifelines-NEXT pilot, we isolated DNA from total microbiome and DNA from virus-like particles (VLP’s) from 30 mother-infant pairs with longitudinally collected samples (n=217) during pregnancy till three months after birth. We performed shotgun sequencing and investigated the abundances of viruses, mainly bacteriophages, along with their bacterial hosts and their strains. Results Both the diversity and composition of the bacteriome as well as the virome differed in mothers and babies (p

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