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eSymposia | Tuberculosis: Science Aimed at Ending the Epidemic


Host transcriptome of diabetic individuals with latent tuberculosis indicates increased downregulation of immune activation and host metabolic genes


Dec 2, 2020 12:00am ‐ Dec 2, 2020 12:00am

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Host transcriptome of diabetic individuals with latent tuberculosis indicates increased downregulation of immune activation and host metabolic genes Kiran Iqbal Masood1, Maliha Yameen1, Nanik Ram1, Qamar Masood1, Bushra Jamil1, Amina Ajmal1, Muhammad Irfan1, Jackie Cliff2, Saba Shahid1 and Zahra Hasan1* 1The Aga Khan University, Stadium Road, P.O.Box 3500, Karachi 74800, Pakistan; 2London School of Hygiene and Tropical Medicine, UK. Submitting author email; Zahra.hasan@aku.edu Background: One third of the world’s population is thought to have latent disease (LTB) caused by infection with Mycobacterium tuberculosis (MTB). Diabetes causes a change in immune activation genes and is thought to result in unfavourable outcomes in tuberculosis (TB). We investigated the impact of LTB on DM cases in a TB endemic region using a host blood transcriptome approach. Methods: We studied host blood transcriptome analysis in healthy endemic controls (EC), those with latent TB (LTB), diabetic individuals (DM) and DM with LTB using the Clariom S Array 21,448 gene set, Affymetrix. Cellular pathway analysis of significant differentially expressed genes (DEGs) up- or down-regulated (log FC (fold change) < -2 or > 2; FDR adjusted P value

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