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eSymposia | Tuberculosis: Science Aimed at Ending the Epidemic


Immune variations throughout the course of tuberculosis treatment and its relationship with adrenal hormone changes in HIV-1 patients co-infected with Mycobacterium tuberculosis


Dec 2, 2020 12:00am ‐ Dec 2, 2020 12:00am

Description

Immune variations throughout the course of tuberculosis treatment and its relationship with adrenal hormone changes in HIV-1 patients co-infected with Mycobacterium tuberculosis Maria Belen Vecchione 1, Denise Anabella Giannone 1, Matías Tomás Angerami 1, Natalia Laufer 1;2, Omar Sued 3 and Maria Florencia Quiroga 1. 1 Universidad de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS). Facultad de Medicina. Buenos Aires, Argentina. 2 Hospital Juan A. Fernández. Buenos Aires, Argentina. 3 Área de Investigaciones Médicas. Fundación Huésped. Buenos Aires, Argentina. Purpose: Risk of developing active TB among HIV-coinfected (HIV-TB) patients is 19 times higher than in HIV-negative individuals. Host's immune response determines resolution or dissemination of TB infection. We aimed to identify immuno-endocrine responses over a six-month follow-up of anti-tuberculous (anti-TB) treatment in HIV+ individuals that were associated with control of TB. Methods: Plasma levels of cortisol, DHEA and DHEA-S (DHEA sulfate), percentages of CD4+ regulatory T cell subsets and number of IFN-γ-secreting cells were determined. Several cytokines, chemokines and C-reactive protein (CRP) levels were measured. Results were analyzed, correlated with clinical data and compared to similar data from HIV-1-monoinfected individuals, HIV infected individuals with latent TB infection and healthy donors. Results: Throughout the course of anti-TB/HIV treatment, reduction of viral load (p

Speaker(s):

  • Maria B. Vecchione, PhD, Instituto de Investigaciones Biomedicas en Retrovirus y SIDA (U.B.A.-CONICET)

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