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Mechanism of Allosteric Regulation in Protein Kinases: A Single Molecule Approach

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Description

Mutations in protein kinases have been associated with the development of cancer. Research efforts in developing inhibitor molecules against the active site of the kinase catalytic subunit have shown positive effects such as prolonging patient survival. Unfortunately, in most cases these treatments result in drug resistance and tumor relapse. An alternative and novel approach is to identify allosteric sites that control protein kinase activity. In the Maillard laboratory, we will develop new single molecule biophysical methods to study how protein kinases are allosterically regulated. This study will guide the development of vitally needed novel therapeutic measures like allosteric inhibitors.

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