Run time: 20m

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On Demand


Lafora Disease & Removing the Pathogenic Glycogen-like Aggregates


Free

Description

Dr. Gentry is part of an upcoming live virtual event, "Intracellular Aggregates: Across the Spectrum of Health and Disease" on Thursday, July 18th, from 3:00 - 4:30PM ET. Register for free and submit your question to the panelists here.

Topics covered include:

  • Comparing/contrasting a small variety of intracellular aggregates (e.g., desmin, APP, TDP-43, synucleins, polyglucosan bodies);
  • Identifying tissues, cell types, and/or sub-cellular compartments where the underlying protein or carbohydrate of interest can be found normally and/or in the disease state;
  • Discussing the normal role for the underlying protein or carbohydrate, and how it may aggregate in normal regenerative tissue or in diseased tissue;
  • Contextualizing these aggregates in terms of their disease relevance;
  • Determining commonalities, for instance among various intracellular aggregate clearance mechanisms;
  • Highlighting theoretical and ongoing translational studies for potential patient impact.


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