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Fatty Liver Disease and Multi-System Complications | EK28


Transcriptomic signature of Western diet-induced lean non-alcoholic fatty liver disease in young adult guinea pigs


Mar 22, 2021 12:00am ‐ Mar 22, 2021 12:00am

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Transcriptomic signature of Western diet-induced lean non-alcoholic fatty liver disease in young adult guinea pigs Ousseynou Sarr1 Ting-Yim Lee2,3,4, and Timothy R.H. Regnault1,4,5 1Department of Physiology and Pharmacology, Western University 2Departments of Medical Imaging, Medical Biophysics, and Oncology, Western University 3Robarts Research Institute, London, Ontario, Canada 4Lawson Health Research Institute 5Children’s Health Research Institute Background: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with obesity but is occurring in increasing numbers in young non-obese patients and is known as "lean NAFLD", whose underlying pathophysiology is not well understood. We aimed to advance mechanistic understanding of lean NAFLD using guinea pigs fed a western diet (WD) during postnatal growing phase. Methods: Normally in utero grown guinea pig offspring were randomly assigned to receive ad libitum a control (CD) diet or WD (high fat/high sugar + 0.25% cholesterol) from weaning to postnatal day (PND) 150 (young adulthood). In vivo computed tomography (CT, ~ PDN 120), organ weight determinations and hepatic histology analyses (150 PDN) were undertaken. Hepatic differentially expressed genes (DEGs) were identified using the GeneChip™ Guinea Pig Gene 1.1 ST Array Plate and TAC software (-22, FRD p-value

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