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Synthetic Biology: At the Crossroads of Genetic Engineering and Human Therapeutics

May 3-4, 2021 | 10:00AM EDT | 2:00PM UTC | 4:00PM CEST*
*Program is in development and subject to change


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Welcome and Keynote Address
10:00am - 10:40am Eastern - May 3, 2021
Jose M. Lora, PhD, Organizer, enGene, Inc; Joshua N. Leonard, PhD, Chair, Northwestern University
Track: Welcome and Keynote Address

Monday
[NOT AVAILABLE ON DEMAND] Cell-Based Therapies of the Future
10:00am - 10:40am Eastern - May 3, 2021
Track: Welcome and Keynote Address

Engineering Life with Synthetic Biology Tools and Principles
10:40am - 01:15pm Eastern - May 3, 2021
Joshua N. Leonard, PhD, Co-Chair, Northwestern University; Zhen Xie, PhD, Co-Chair, Tsinghua University
Track: Engineering Life with Synthetic Biology Tools and Principles

Monday
Advancing the Frontiers of Design-Driven Engineering for Programmable Cell-Based Therapies
10:40am - 11:05am Eastern - May 3, 2021
Joshua N. Leonard, PhD, Northwestern University
Track: Engineering Life with Synthetic Biology Tools and Principles

Monday
Engineered Gene Circuits for Diagnostics and Therapeutics
11:05am - 11:30am Eastern - May 3, 2021
Timothy K. Lu, MD, PhD, Massachusetts Institute of Technology
Track: Engineering Life with Synthetic Biology Tools and Principles

Monday
[NOT AVAILABLE ON DEMAND] Modulating Bacterial Populations with Synthetic Biology
11:40am - 12:05pm Eastern - May 3, 2021
Jeff Hasty, PhD, University of California, San Diego
Track: Engineering Life with Synthetic Biology Tools and Principles

Monday
[NOT AVAILABLE ON DEMAND] Synthetic Biology in Immunotherapy
12:05pm - 12:30pm Eastern - May 3, 2021
Yvonne Y. Chen, PhD, University of California, Los Angeles
Track: Engineering Life with Synthetic Biology Tools and Principles

Monday
Oncolytic Adenovirus Programmed by Synthetic Gene Circuit for Cancer Immunotherapy
12:30pm - 12:55pm Eastern - May 3, 2021
Zhen Xie, PhD, Tsinghua University
Track: Engineering Life with Synthetic Biology Tools and Principles

Monday
Reprogramming Microbes to Rewire Host-Microbiome Interactions
12:55pm - 01:15pm Eastern - May 3, 2021
Matthew Chang, PhD, National University of Singapore
Track: Engineering Life with Synthetic Biology Tools and Principles

Monday
Career Roundtable
02:30pm - 03:30pm Eastern - May 3, 2021
Roger Geiger, PhD, Panelist, Institute for Research in Biomedicine; Virginia W. Cornish, PhD, Panelist, Columbia University; David Hava, PhD, Panelist, Synlogic, Inc.
Track: Keystone Symposia Roundtables

Bioengineering Cells and Viruses in Disease
05:00pm - 08:00pm Eastern - May 3, 2021
Francisco J. Quintana, PhD, Co-Chair, Harvard Medical School and the Broad Institute of MIT and Harvard; Jason Paul Lynch, PhD, Co-Chair, Massachusetts General Hospital
Track: Bioengineering Cells and Viruses in Disease

Monday
Engineering E. coli for the Targeted Injections of Proteins into Tumor Cells
05:00pm - 05:25pm Eastern - May 3, 2021
Luis Ángel Fernández, PhD, National Center of Biotechnology - CSIC
Track: Bioengineering Cells and Viruses in Disease

Monday
Synthetic Immunotherapy with Engineered Bacteria
05:25pm - 05:50pm Eastern - May 3, 2021
Jose M. Lora, PhD, enGene, Inc
Track: Bioengineering Cells and Viruses in Disease

Monday
New Strategies for Improving the Therapeutic Potential of Oncolytic Viruses in Cancer and Other Diseases
05:50pm - 06:15pm Eastern - May 3, 2021
Howard L. Kaufman, MD, Massachusetts General Hospital
Track: Bioengineering Cells and Viruses in Disease

Monday
Engineering Bacteria and Yeast for the Control of Inflammation
06:15pm - 06:40pm Eastern - May 3, 2021
Francisco J. Quintana, PhD, Harvard Medical School and the Broad Institute of MIT and Harvard
Track: Bioengineering Cells and Viruses in Disease

Monday
Metabolic Modulation of the Tumor Microenvironment with Synthetic Biology
06:55pm - 07:20pm Eastern - May 3, 2021
Roger Geiger, PhD, Institute for Research in Biomedicine
Track: Bioengineering Cells and Viruses in Disease

Monday
Leveraging Bacterial Secretion Systems to Develop Therapeutic Designer Probiotics
07:20pm - 07:45pm Eastern - May 3, 2021
Cammie Lesser, MD, PhD, Massachusetts General Hospital
Track: Bioengineering Cells and Viruses in Disease

Monday
Short Talk: Development of Designer Probiotics for the Treatment of Inflammatory Bowel Disease
07:45pm - 08:00pm Eastern - May 3, 2021
Jason Paul Lynch, PhD, Massachusetts General Hospital
Track: Bioengineering Cells and Viruses in Disease

Synthetic Biology: Industry Perspective
10:00am - 12:40pm Eastern - May 4, 2021
Breanna DiAndreth, PhD, Co-Chair, A2 Biotherapeutics, Inc.; Jose M. Lora, PhD, Co-Chair, enGene, Inc
Track: Synthetic Biology: Industry Perspective

Tuesday
Targeting Metabolic Diseases with Synthetic Biotic Medicines
10:00am - 10:25am Eastern - May 4, 2021
David Hava, PhD, Synlogic, Inc.
Track: Synthetic Biology: Industry Perspective

Tuesday
Expanding the Synthetic Capabilities of Yeast
10:25am - 10:50am Eastern - May 4, 2021
Virginia W. Cornish, PhD, Columbia University
Track: Synthetic Biology: Industry Perspective

Tuesday
Precise Targeting of Acute Myeloid Leukemia with OR / NOT Logic-Gated Gene Circuits in CAR-NK Cells
10:50am - 11:15am Eastern - May 4, 2021
Gary K. Lee, PhD, Senti Biosciences
Track: Synthetic Biology: Industry Perspective

Tuesday
Short Talk: Engineered T Cells Directed at Tumors with Defined Allelic Loss
11:40am - 11:55am Eastern - May 4, 2021
Breanna DiAndreth, PhD, A2 Biotherapeutics, Inc.
Track: Synthetic Biology: Industry Perspective

Tuesday
Short Talk: Machine Learning Models for Predictive Bioengineering
11:55am - 12:10pm Eastern - May 4, 2021
Michael Fero, PhD, TeselaGen Biotechnology
Track: Synthetic Biology: Industry Perspective

Tuesday
Short Talk: Engineering Reversible Logic Based Synthetic Gene Circuits in Living Bacteria and Its Potential Application in Therapeutic Delivery to Human Cancer Cells
12:10pm - 12:25pm Eastern - May 4, 2021
Rajkamal Srivastava, MS, Saha Institute of Nuclear Physics, HBNI
Track: Synthetic Biology: Industry Perspective

Tuesday
Short Talk: Anti-Arrhythmic Ion Channel Engineering Enables Self-Restoration of Cardiac Rhythm: Towards Synthetic Biomedicine in Cardiology
12:25pm - 12:40pm Eastern - May 4, 2021
Tim Joseph Chris De Coster, PhD, Leiden University Medical Center
Track: Synthetic Biology: Industry Perspective

Tuesday
Meet the Editors Roundtable
02:30pm - 03:30pm Eastern - May 4, 2021
George Inglis, PhD, Panelist, Nature Portfolio; Kusumika Mukherjee, PhD, Panelist, Cell Press; Maria Polychronidou, PhD, Panelist, Molecular Systems Biology (EMBO Press)
Track: Keystone Symposia Roundtables

Next Generation Synthetic Biology
05:00pm - 07:50pm Eastern - May 4, 2021
Tingxi (Tim) Guo, PhD, Co-Chair, Massachusetts Institute of Technology; Samira Kiani, MD, Co-Chair, University of Pittsburgh School of Medicine; Owen J. L. Rackham, PhD, Co-Chair, Duke-NUS
Track: Next Generation Synthetic Biology

Tuesday
Enhancing Engineered Immune Cell Therapies with Synthetic Biology
05:00pm - 05:25pm Eastern - May 4, 2021
Kole T. Roybal, PhD, University of California, San Francisco
Track: Next Generation Synthetic Biology

Tuesday
Using Data-Driven Approaches to Develop Engineered Cell Therapies
05:25pm - 05:50pm Eastern - May 4, 2021
Track: Next Generation Synthetic Biology

Tuesday
CRISPR-Based Genetic Circuits: Immunomodulation as a Tool to Address Safety and Developing Therapeutics
05:50pm - 06:15pm Eastern - May 4, 2021
Samira Kiani, MD, University of Pittsburgh School of Medicine
Track: Next Generation Synthetic Biology

Tuesday
Short Talk: Next Generation Receptors for the Enhanced Control of Cellular Immunotherapy
06:40pm - 06:55pm Eastern - May 4, 2021
Iowis Zhu, BS, University of California, San Francisco
Track: Next Generation Synthetic Biology

Tuesday
Short Talk: T Cell Circuits that Sense Antigen Density with Ultrasensitive Threshold
06:55pm - 07:10pm Eastern - May 4, 2021
Rogelio A. Hernandez-Lopez, PhD, University of California, San Francisco
Track: Next Generation Synthetic Biology

Tuesday
Short Talk: Sense-and-Respond Payload Delivery using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation
07:10pm - 07:25pm Eastern - May 4, 2021
Tingxi (Tim) Guo, PhD, Massachusetts Institute of Technology
Track: Next Generation Synthetic Biology

Tuesday
Short Talk: Highly Programmable Synthetic Transcription System for Precision Control of Gene Expression and Functional Phenotype in Mammalian Cells
07:25pm - 07:40pm Eastern - May 4, 2021
William C.W. Chen, MD, PhD, Massachusetts Institute of Technology
Track: Next Generation Synthetic Biology

Tuesday
Closing Remarks
07:40pm - 07:50pm Eastern - May 4, 2021
Track: Next Generation Synthetic Biology