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Hematopoiesis

April 21-23, 2021 | 10:00AM EDT | 2:00PM UTC | 4:00PM CEST*
*Program is in development and subject to change


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Welcome and Keynote Address
10:00am - 10:40am Eastern - April 21, 2021 | Room: V200 - Ian Loudon
Daniel Starczynowski, PhD, Organizer, Cincinnati Children's Hospital Medical Center; Benjamin L. Ebert, MD, PhD, Keynote, Dana-Farber Cancer Institute
Track: Welcome and Keynote Address

Wednesday
Clonal Hematopoiesis in Hematologic Malignancies and Cardiovascular Disease
10:00am - 10:40am Eastern - April 21, 2021 | Room: V200 - Ian Loudon
Benjamin L. Ebert, MD, PhD, Dana-Farber Cancer Institute
Track: Welcome and Keynote Address

Hematopoiesis during Stress and Aging
10:40am - 01:00pm Eastern - April 21, 2021 | Room: Multi-Room Split Session
Katherine Y. King, MD, PhD, Co-Chair, Baylor College of Medicine; Jennifer Trowbridge, PhD, Co-Chair, The Jackson Laboratory; Ido Amit, PhD, Weizmann Institute; H. Leighton Grimes, PhD, Cincinnati Children's Hospital Medical Center; Anna E. Beaudin, PhD, University of Utah School of Medicine; Serine Avagyan, MD, PhD, Boston Children’s Hospital Cancer and Blood Disorders Center
Track: Hematopoiesis during Stress and Aging

Wednesday
The Power of ONE: Immunology in the Age of Single Cell Genomics
10:40am - 11:05am Eastern - April 21, 2021 | Room: V300 - Chad Littman
Ido Amit, PhD, Weizmann Institute
Track: Hematopoiesis during Stress and Aging

Wednesday
Infection Is a Driver of Dnmt3a-Mutant Clonal Hematopoiesis
11:05am - 11:30am Eastern - April 21, 2021 | Room: V300 - Chad Littman
Katherine Y. King, MD, PhD, Baylor College of Medicine
Track: Hematopoiesis during Stress and Aging

Wednesday
Microenvironmental Regulation of HSC Aging
11:40am - 12:05pm Eastern - April 21, 2021 | Room: V100 - Ben Schramm
Jennifer Trowbridge, PhD, The Jackson Laboratory
Track: Hematopoiesis during Stress and Aging

Wednesday
Transitional States in Hematopoiesis
12:05pm - 12:30pm Eastern - April 21, 2021 | Room: V100 - Ben Schramm
H. Leighton Grimes, PhD, Cincinnati Children's Hospital Medical Center
Track: Hematopoiesis during Stress and Aging

Wednesday
Short Talk: Prenatal Inflammation Perturbs Fetal Hematopoiesis and Causes Persistent Changes to Postnatal Immunity
12:30pm - 12:45pm Eastern - April 21, 2021 | Room: V100 - Ben Schramm
Anna E. Beaudin, PhD, University of Utah School of Medicine
Track: Hematopoiesis during Stress and Aging

Wednesday
Short Talk: Clonal Hematopoiesis Results from the Response of Stem and Progenitor Cells to Inflammatory Cues from Mutant Mature Cells
12:45pm - 01:00pm Eastern - April 21, 2021 | Room: V100 - Ben Schramm
Serine Avagyan, MD, PhD, Boston Children’s Hospital Cancer and Blood Disorders Center
Track: Hematopoiesis during Stress and Aging

Wednesday
Career Roundtable
02:30pm - 03:30pm Eastern - April 21, 2021
Fernando D. Camargo, PhD, Panelist, Boston Children's Hospital; Hanna K.A. Mikkola, MD, PhD, Panelist, University of California, Los Angeles; Daniel Starczynowski, PhD, Panelist, Cincinnati Children's Hospital Medical Center
Track: Keystone Symposia Roundtables

Microenvironment and Signaling
05:00pm - 08:00pm Eastern - April 21, 2021 | Room: Multi-Room Split Session
Kateri Ann Moore, DVM, Co-Chair, Ichan School of Medicine at Mount Sinai; Timm Schroeder, PhD, Co-Chair, ETH Zürich; Cristina Lo Celso, PhD, Imperial College London; Sir Francis Crick Institute; Sean J. Morrison, PhD, University of Texas Southwestern Medical Center; Sisi Chen, PhD, Memorial Sloan Kettering Cancer Center; Adil Rasheed, PhD, University of Ottawa Heart Institute; Anthony D. Ho, MD, Heidelberg University; Christina Marie Termini, PhD, University of California, Los Angeles; Zanshe Thompson, MS, University of South Carolina; Melissa A. Meyer, PhD, La Jolla Institute for Immunology
Track: Microenvironment and Signaling

Wednesday
Long-Term Single-Cell Quantification: New Tools for Old Questions
05:00pm - 05:30pm Eastern - April 21, 2021 | Room: V300 - Chad Littman
Timm Schroeder, PhD, ETH Zürich
Track: Microenvironment and Signaling

Wednesday
Microenvironmental Regulation of HSC Function
05:30pm - 06:00pm Eastern - April 21, 2021 | Room: V300 - Chad Littman
Cristina Lo Celso, PhD, Imperial College London; Sir Francis Crick Institute
Track: Microenvironment and Signaling

Wednesday
Niche Biology: Beyond Growth Factors
06:30pm - 06:55pm Eastern - April 21, 2021 | Room: V300 - Chad Littman
Sean J. Morrison, PhD, University of Texas Southwestern Medical Center
Track: Microenvironment and Signaling

Wednesday
Short Talk: Altered LZTR1 and RIT1 Signaling Drive Clonal Hematopoietic Transformation
06:55pm - 07:10pm Eastern - April 21, 2021 | Room: V100 - Ben Schramm
Sisi Chen, PhD, Memorial Sloan Kettering Cancer Center
Track: Microenvironment and Signaling

Wednesday
Short Talk: Mixed Lineage Kinase Domain-Like Protein (MLKL) Maintains the Splenic Microenvironment to Restrict Hematopoiesis During Atherosclerosis
07:10pm - 07:25pm Eastern - April 21, 2021 | Room: V100 - Ben Schramm
Adil Rasheed, PhD, University of Ottawa Heart Institute
Track: Microenvironment and Signaling

Wednesday
Short Talk: Hematopoietic Stem Cells with Elevated Central Carbon Metabolism Drive the Aging Process and Harbor Clonal Hematopoiesis
07:25pm - 07:40pm Eastern - April 21, 2021 | Room: V100 - Ben Schramm
Anthony D. Ho, MD, Heidelberg University
Track: Microenvironment and Signaling

Wednesday
Short Talk: Semaphorin 3A Controls Bone Marrow Vascular Regeneration and Hematopoietic Reconstitution
07:40pm - 07:55pm Eastern - April 21, 2021 | Room: V100 - Ben Schramm
Christina Marie Termini, PhD, University of California, Los Angeles
Track: Microenvironment and Signaling

Wednesday
Short Talk: Ing4 Suppresses Quiescence and Inflammation in Hematopoietic Stem Cells
07:55pm - 08:10pm Eastern - April 21, 2021 | Room: V100 - Ben Schramm
Zanshe Thompson, MS, University of South Carolina
Track: Microenvironment and Signaling

Wednesday
Short Talk: Discovery of a Neutrophil Subset with B Cell Features and the Ability to Modulate CD4+ T Cells
08:10pm - 08:25pm Eastern - April 21, 2021 | Room: V100 - Ben Schramm
Melissa A. Meyer, PhD, La Jolla Institute for Immunology
Track: Microenvironment and Signaling

HSC Biology and Development
10:00am - 01:05pm Eastern - April 22, 2021 | Room: Multi-Room Split Session
Hanna K.A. Mikkola, MD, PhD, Co-Chair, University of California, Los Angeles; Fernando D. Camargo, PhD, Co-Chair, Boston Children's Hospital; Shannon L. McKinney-Freeman, PhD, St. Jude Children's Research Hospital; E. Camilla Forsberg, PhD, University of California, Santa Cruz; Leonard I. Zon, MD, HHMI/Boston Children's Hospital; Catherine S. Rhee, PhD, Harvard University/ MGH; Grant Rowe, MD, PhD, Boston Children's Hospital; YeEun Kim, BS, Stanford; Bianca A. Ulloa, MS, Albert Einstein College of Medicine; Hiromitsu Nakauchi, Stanford University
Track: HSC Biology and Development

Thursday
Assessing HSC Potential in vivo at the Single Cell Level
10:00am - 10:25am Eastern - April 22, 2021 | Room: V300 - Chad Littman
Fernando D. Camargo, PhD, Boston Children's Hospital
Track: HSC Biology and Development

Thursday
Ontogeny of the Hematopoietic Hierarchy
10:25am - 10:50am Eastern - April 22, 2021 | Room: V300 - Chad Littman
Shannon L. McKinney-Freeman, PhD, St. Jude Children's Research Hospital
Track: HSC Biology and Development

Thursday
Chasing Mavericks: The Quest to Understand Hematopoietic Stem Cell Waves
10:50am - 11:15am Eastern - April 22, 2021 | Room: V300 - Chad Littman
E. Camilla Forsberg, PhD, University of California, Santa Cruz
Track: HSC Biology and Development

Thursday
Embryonic Macrophage-Hematopoietic Stem Cell Interactions Determine Adult
11:25am - 11:50am Eastern - April 22, 2021 | Room: V100 - Ben Schramm
Leonard I. Zon, MD, HHMI/Boston Children's Hospital
Track: HSC Biology and Development

Thursday
Short Talk: Rigidity of Cell Fate and Function among Monocytes
11:50am - 12:05pm Eastern - April 22, 2021 | Room: V100 - Ben Schramm
Catherine S. Rhee, PhD, Harvard University/ MGH
Track: HSC Biology and Development

Thursday
Short Talk: Hematopoiesis at Single Cell Resolution Spanning Human Development and Maturation
12:05pm - 12:20pm Eastern - April 22, 2021 | Room: V100 - Ben Schramm
Grant Rowe, MD, PhD, Boston Children's Hospital
Track: HSC Biology and Development

Thursday

Thursday
Short Talk: Definitive Hematopoietic Stem Cells Minimally Contribute to Embryonic Hematopoiesis
12:35pm - 12:50pm Eastern - April 22, 2021 | Room: V100 - Ben Schramm
Bianca A. Ulloa, MS, Albert Einstein College of Medicine
Track: HSC Biology and Development

Thursday
Short Talk: Selective Expansion of Human HSCs in Cytokine-Free Chemically-Defined Medium
12:50pm - 01:05pm Eastern - April 22, 2021 | Room: V100 - Ben Schramm
Hiromitsu Nakauchi, Stanford University
Track: HSC Biology and Development

Thursday
Meet the Editors Roundtable
02:30pm - 03:30pm Eastern - April 22, 2021
Daniel Klimmeck, PhD, Panelist, EMBO Journal; Valerie Kouskoff, PhD, Panelist, University of Manchester; Eric Sawey, PhD, Panelist, Journal of Experimental Medicine (JEM); Swapnika Ramu, PhD, Panelist, Cell Press; Tanya Bondar, PhD, Panelist, Blood Cancer Discovery of the American Association for Cancer Research
Track: Keystone Symposia Roundtables

Hematologic Malignancies
05:00pm - 08:00pm Eastern - April 22, 2021 | Room: Multi-Room Split Session
Daniel Starczynowski, PhD, Co-Chair, Cincinnati Children's Hospital Medical Center; Ross L. Levine, MD, Co-Chair, Memorial Sloan Kettering Cancer Center; Michael G. Kharas, PhD, Memorial Sloan Kettering Cancer Center; Iannis Aifantis, PhD, New York University School of Medicine; Anna-Katharina Wirth, MS, Helmholtz Zentrum Munich; Jing Fang, MD, PhD, University of South Carolina; Amitava Sengupta, PhD, Indian Institute of Chemical Biology
Track: Hematologic Malignancies

Thursday
Adaptive Response of MDS Cells to the Inflammatory Milieu Contributes to Sustained Myeloid Expansion and a Competitive Advantage
05:00pm - 05:25pm Eastern - April 22, 2021 | Room: V100 - Ben Schramm
Daniel Starczynowski, PhD, Cincinnati Children's Hospital Medical Center
Track: Hematologic Malignancies

Thursday
RNA Binding Proteins in Leukemia
05:25pm - 05:50pm Eastern - April 22, 2021 | Room: V100 - Ben Schramm
Michael G. Kharas, PhD, Memorial Sloan Kettering Cancer Center
Track: Hematologic Malignancies

Thursday
RNA Binding Proteins as Regulators of Myeloid Leukemia Growth and Self-Renewal
05:50pm - 06:15pm Eastern - April 22, 2021 | Room: V100 - Ben Schramm
Iannis Aifantis, PhD, New York University School of Medicine
Track: Hematologic Malignancies

Thursday
Role of Mutations in Epigenetic Regulators in Clonal Hematopoiesis and Evolution to AML
06:35pm - 07:00pm Eastern - April 22, 2021 | Room: V200 - Ian Loudon
Ross L. Levine, MD, Memorial Sloan Kettering Cancer Center
Track: Hematologic Malignancies

Thursday
Short Talk: Modelling Acquired Treatment Resistance in PDX ALL in vivo Reveals Identical Therapeutic Targets Regardless of Diverse Genomic Alterations
07:00pm - 07:15pm Eastern - April 22, 2021 | Room: V200 - Ian Loudon
Anna-Katharina Wirth, MS, Helmholtz Zentrum Munich
Track: Hematologic Malignancies

Thursday
Short Talk: SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML
07:15pm - 07:30pm Eastern - April 22, 2021 | Room: V200 - Ian Loudon
Gaurav S. Choudhary, PhD, Albert Einstein College of Medicine
Track: Hematologic Malignancies

Thursday
Short Talk: Dissect the Function of GPR68 in Acute Myeloid Leukemia and Hematopoietic Stem Cells
07:30pm - 07:45pm Eastern - April 22, 2021 | Room: V200 - Ian Loudon
Jing Fang, MD, PhD, University of South Carolina
Track: Hematologic Malignancies

Thursday
Short Talk: Polybromo SWI/SNF Integrates Chromatin Remodeling & BMP/TGF-β Signaling to Determine Mesenchymal Stromal Osteolineage Commitment and Hematopoiesis
07:45pm - 08:00pm Eastern - April 22, 2021 | Room: V200 - Ian Loudon
Amitava Sengupta, PhD, Indian Institute of Chemical Biology
Track: Hematologic Malignancies

Hematologic Malignancies: Biology and Therapy
10:00am - 01:00pm Eastern - April 23, 2021 | Room: Multi-Room Split Session
Ravi Majeti, MD, PhD, Co-Chair, Stanford University; Catriona H.M. Jamieson, MD, PhD, Co-Chair, University of California, San Diego; Kate Yen, PhD, Auron Therapeutics; Melvin Edward Thomas III, PhD, St. Jude Children's Research Hospital; Panagiotis Ntziachristos, PhD, Northwestern University; Elvin Wagenblast, PhD, University Health Network, Princess Margaret Cancer Centre; Liping Li, MD, PhD, Johns Hopkins University; Shailaja Hegde, PhD, University of Cincinnati; Michael E. Lawler, MS, Thomas Jefferson University
Track: Hematologic Malignancies: Biology and Therapy

Friday
Reprogramming B-ALL into APCs for Cancer Vaccination
10:00am - 10:25am Eastern - April 23, 2021 | Room: V100 - Ben Schramm
Ravi Majeti, MD, PhD, Stanford University
Track: Hematologic Malignancies: Biology and Therapy

Friday
Differentiation Therapy in AML
10:25am - 10:50am Eastern - April 23, 2021 | Room: V100 - Ben Schramm
Kate Yen, PhD, Auron Therapeutics
Track: Hematologic Malignancies: Biology and Therapy

Friday
Innate Immune Deaminases Fuel Pre-Leukemia Stem Cell Malignant Transformation
10:50am - 11:15am Eastern - April 23, 2021 | Room: V100 - Ben Schramm
Catriona H.M. Jamieson, MD, PhD, University of California, San Diego
Track: Hematologic Malignancies: Biology and Therapy

Friday
Short Talk: Germline Mutations in SAMD9 and SAMD9L Impair Hematopoietic Cell Function
11:30am - 11:45am Eastern - April 23, 2021 | Room: V300 - Chad Littman
Melvin Edward Thomas III, PhD, St. Jude Children's Research Hospital
Track: Hematologic Malignancies: Biology and Therapy

Friday
Short Talk: Characterizing Mechanisms Controlling Aberrant Spliceosome Levels and Its Impact on Therapy Response in Acute Lymphoblastic Leukemia
11:45am - 12:00pm Eastern - April 23, 2021 | Room: V300 - Chad Littman
Panagiotis Ntziachristos, PhD, Northwestern University
Track: Hematologic Malignancies: Biology and Therapy

Friday
Short Talk: Mapping the Cellular Origin and Developmental Context of Myeloid Leukemia in Down Syndrome
12:00pm - 12:15pm Eastern - April 23, 2021 | Room: V300 - Chad Littman
Elvin Wagenblast, PhD, University Health Network, Princess Margaret Cancer Centre
Track: Hematologic Malignancies: Biology and Therapy

Friday
Short Talk: High Mobility Group A1 Chromatin Remodeling Proteins Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce GATA2 and Cell Cycle Progression
12:15pm - 12:30pm Eastern - April 23, 2021 | Room: V300 - Chad Littman
Liping Li, MD, PhD, Johns Hopkins University
Track: Hematologic Malignancies: Biology and Therapy

Friday
Short Talk: Cell Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α
12:30pm - 12:45pm Eastern - April 23, 2021 | Room: V300 - Chad Littman
Shailaja Hegde, PhD, University of Cincinnati
Track: Hematologic Malignancies: Biology and Therapy

Friday
Short Talk: Interrogation of TLR2 Inflammatory Signaling in AML
12:45pm - 01:00pm Eastern - April 23, 2021 | Room: V300 - Chad Littman
Michael E. Lawler, MS, Thomas Jefferson University
Track: Hematologic Malignancies: Biology and Therapy

Transcription and Epigenetics
05:00pm - 08:00pm Eastern - April 23, 2021 | Room: Multi-Room Split Session
Atsushi Iwama, MD, PhD, Co-Chair, University of Tokyo; Margaret A. Goodell, PhD, Co-Chair, Baylor College of Medicine; Patricia Ernst, PhD, University of Colorado Anschutz Medical Center; Hanna K.A. Mikkola, MD, PhD, University of California, Los Angeles; Vikram R. Paralkar, MD, University of Pennsylvania; Maxim Pimkin, MD, PhD, Dana Farber Cancer Institute; Xiaotian Zhang, PhD, University of Michigan
Track: Transcription and Epigenetics

Friday
Chromatin Accessibility in MDS Stem and Progenitor Cells
05:00pm - 05:25pm Eastern - April 23, 2021 | Room: V200 - Ian Loudon
Atsushi Iwama, MD, PhD, University of Tokyo
Track: Transcription and Epigenetics

Friday
MLL1 Levels and Activity Influence Hematopoietic Development
05:25pm - 05:50pm Eastern - April 23, 2021 | Room: V200 - Ian Loudon
Patricia Ernst, PhD, University of Colorado Anschutz Medical Center
Track: Transcription and Epigenetics

Friday
Mechanisms Regulating Human Hematopoietic Stem Cell Specification and Self-Renewal
05:50pm - 06:15pm Eastern - April 23, 2021 | Room: V200 - Ian Loudon
Hanna K.A. Mikkola, MD, PhD, University of California, Los Angeles
Track: Transcription and Epigenetics

Friday
Clonal Competition Among Hematopoietic Stem Cells
06:40pm - 07:05pm Eastern - April 23, 2021 | Room: V300 - Chad Littman
Margaret A. Goodell, PhD, Baylor College of Medicine
Track: Transcription and Epigenetics

Friday
Short Talk: An Atlas of Hematopoietic Transcription Factor Binding to Ribosomal DNA Reveals a Role for CEBPA in Regulation of rRNA Transcription
07:05pm - 07:20pm Eastern - April 23, 2021 | Room: V300 - Chad Littman
Vikram R. Paralkar, MD, University of Pennsylvania
Track: Transcription and Epigenetics

Friday
Short Talk: A Combinatorial Transcriptional Mechanism of Immune Escape in AML
07:20pm - 07:35pm Eastern - April 23, 2021 | Room: V300 - Chad Littman
Maxim Pimkin, MD, PhD, Dana Farber Cancer Institute
Track: Transcription and Epigenetics

Friday
Short Talk: 3D Genomics Analysis in Acute Myeloid Leukemia Reveals the Activation of the Homeobox Genes Driven Leukemic-Specific 3D Network
07:35pm - 07:50pm Eastern - April 23, 2021 | Room: V300 - Chad Littman
Xiaotian Zhang, PhD, University of Michigan
Track: Transcription and Epigenetics

Friday
Closing Remarks
07:50pm - 08:00pm Eastern - April 23, 2021 | Room: V300 - Chad Littman
Track: Transcription and Epigenetics