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Emerging Cell Therapies:
Realizing the Vision of NextGen Cell Therapeutics

January 25-27, 2021 | 10:00AM EST | 3:00PM UTC | 4:00PM CET*
*Program is in development and subject to change


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Welcoming Remarks and Keynote Address
10:00am - 10:40am Eastern - January 25, 2021 | Room: V300 Guy Coombes
Kole T. Roybal, PhD, Organizer, University of California, San Francisco; David Baker, PhD, Keynote, University of Washington
Track: Welcoming Remarks and Keynote Address

Monday
Computational Protein Design for Next-Generation Cellular Therapeutics
10:00am - 10:40am Eastern - January 25, 2021 | Room: V300 Guy Coombes
David Baker, PhD, Keynote, University of Washington
Track: Welcoming Remarks and Keynote Address

The Current State of Cellular Therapies for Cancer: Lessons from the Clinic
10:40am - 01:00pm Eastern - January 25, 2021 | Room: Multi Tech Session
Kole T. Roybal, PhD, Co-Chair, University of California, San Francisco; Yvonne Y. Chen, PhD, Co-Chair, University of California, Los Angeles
Track: The Current State of Cellular Therapies for Cancer: Lessons from the Clinic

Monday
Next-Generation CART Approaches Exploiting Natural Killer Receptor Targeting
10:40am - 11:05am Eastern - January 25, 2021 | Room: V200 Ronney Laws
Track: The Current State of Cellular Therapies for Cancer: Lessons from the Clinic

Monday
[NOT AVAILABLE ON DEMAND] New T Cell Therapeutics
11:05am - 11:30am Eastern - January 25, 2021 | Room: V200 Ronney Laws
Marcela V. Maus, MD, PhD, Harvard Medical School
Track: The Current State of Cellular Therapies for Cancer: Lessons from the Clinic

Monday
CAR T Cells for the Treatment of Brain Malignancies
11:45am - 12:10pm Eastern - January 25, 2021
Christine E. Brown, PhD, Beckman Research Institute, City of Hope
Track: The Current State of Cellular Therapies for Cancer: Lessons from the Clinic

Monday
Manufacturing Next-Generation Cellular Therapies
12:10pm - 12:35pm Eastern - January 25, 2021
Isabelle Riviere, PhD, Memorial Sloan-Kettering Cancer Center
Track: The Current State of Cellular Therapies for Cancer: Lessons from the Clinic

Monday
Allogeneic CAR T Therapy for the Treatment of Cancer
12:35pm - 01:00pm Eastern - January 25, 2021
Barbra Sasu, PhD, Allogene Therapeutics
Track: The Current State of Cellular Therapies for Cancer: Lessons from the Clinic

Monday
Career Roundtable
02:30pm - 03:30pm Eastern - January 25, 2021
Darrell J. Irvine, PhD, Panelist, Massachusetts Institute of Technology; Marcela V. Maus, MD, PhD, Panelist, Harvard Medical School; Jane L. Grogan, PhD, Panelist, Arsenal Biosciences
Track: Career Roundtable

New Approaches for Programming Cellular Therapeutics
05:00pm - 08:00pm Eastern - January 25, 2021 | Room: Multi Tech Session
Alex Marson, MD, PhD, Co-Chair, University of California, San Francisco; Ahmad S. Khalil, PhD, Co-Chair, Boston University
Track: New Approaches for Programming Cellular Therapeutics

Monday
Reprogramming Immune Cell Therapeutics with Non-Viral Gene Editing Approaches
05:00pm - 05:25pm Eastern - January 25, 2021 | Room: V200 Ronney Laws
Alex Marson, MD, PhD, University of California, San Francisco
Track: New Approaches for Programming Cellular Therapeutics

Monday
Engineered Cytokines for Cancer Immunotherapy
05:25pm - 05:50pm Eastern - January 25, 2021 | Room: V200 Ronney Laws
Aaron Ring, MD, PhD, Yale School of Medicine
Track: New Approaches for Programming Cellular Therapeutics

Monday
Expanding the Functional Capacity of Therapeutic Immune Cells
05:50pm - 06:15pm Eastern - January 25, 2021 | Room: V200 Ronney Laws
Dario Campana, MD, PhD, National University of Singapore
Track: New Approaches for Programming Cellular Therapeutics

Monday
Design of Eukaryotic Gene Regulatory Circuits
06:15pm - 06:40pm Eastern - January 25, 2021 | Room: V200 Ronney Laws
Ahmad S. Khalil, PhD, Boston University
Track: New Approaches for Programming Cellular Therapeutics

Monday
Short Talk: Elimination of Mouse B Cells by Non-Virally Engineered CAR19 Knock-In T Cells
06:45pm - 07:00pm Eastern - January 25, 2021
Romina Marone, PhD, University of Basel, DBM
Track: New Approaches for Programming Cellular Therapeutics

Monday
Short Talk: Engineering B Cells in-vivo Elicits Potent Cellular and Serological Responses in Mice
07:00pm - 07:15pm Eastern - January 25, 2021
Alessio David Nahmad, Tel Aviv University
Track: New Approaches for Programming Cellular Therapeutics

Monday
Short Talk: Efficient Gene Knockout in Primary Myeloid Cells by Non-Viral Delivery of CRISPR-Cas9
07:15pm - 07:30pm Eastern - January 25, 2021
Aditya Murthy, PhD, Genentech, Inc.
Track: New Approaches for Programming Cellular Therapeutics

Monday
Short Talk: Microfluidic Cell Squeezing Enables the Generation of Novel Cell Therapies for Diverse Clinical Applications
07:30pm - 07:45pm Eastern - January 25, 2021
Jonathan B. Gilbert, PhD, SQZ Biotechnology
Track: New Approaches for Programming Cellular Therapeutics

Monday
Short Talk: Using Data-Driven Approaches to Develop Engineered Cell Therapies
07:45pm - 08:00pm Eastern - January 25, 2021
Track: New Approaches for Programming Cellular Therapeutics

Next-Generation Cellular Therapeutics for Cancer
10:00am - 01:00pm Eastern - January 26, 2021 | Room: Multi Tech Session
Yvonne Y. Chen, PhD, Co-Chair, University of California, Los Angeles; Kole T. Roybal, PhD, Co-Chair, University of California, San Francisco
Track: Next-Generation Cellular Therapeutics for Cancer

Tuesday
[NOT AVAILABLE ON DEMAND] Enhancing T-Cell Therapies by Rational Biomolecular Engineering
10:00am - 10:25am Eastern - January 26, 2021 | Room: V200 Ronney Laws
Yvonne Y. Chen, PhD, University of California, Los Angeles
Track: Next-Generation Cellular Therapeutics for Cancer

Tuesday
T Cell Therapies with Engineered Control Systems
10:25am - 10:50am Eastern - January 26, 2021 | Room: V200 Ronney Laws
Martin Pule, MD, University College London
Track: Next-Generation Cellular Therapeutics for Cancer

Tuesday
Control and Customization of Immune Cell Therapies for Cancer
10:50am - 11:15am Eastern - January 26, 2021 | Room: V200 Ronney Laws
Kole T. Roybal, PhD, University of California, San Francisco
Track: Next-Generation Cellular Therapeutics for Cancer

Tuesday
Development of Next-Generation T Cell Therapies
11:15am - 11:40am Eastern - January 26, 2021 | Room: V200 Ronney Laws
Jane L. Grogan, PhD, Arsenal Biosciences
Track: Next-Generation Cellular Therapeutics for Cancer

Tuesday
Synthetic Biology Tools to Stimulate Anti-Tumor Immunity
12:05pm - 12:30pm Eastern - January 26, 2021
Timothy K. Lu, MD, PhD, Massachusetts Institute of Technology
Track: Next-Generation Cellular Therapeutics for Cancer

Tuesday
Short Talk: Mechanisms of Adoptive T Cell Micropharmacies
12:30pm - 12:45pm Eastern - January 26, 2021
Christopher Bourne, Memorial Sloan Kettering Cancer Center
Track: Next-Generation Cellular Therapeutics for Cancer

Tuesday
Short Talk: T Cell Circuits that Sense Antigen Density with an Ultrasensitive Threshold
12:45pm - 01:00pm Eastern - January 26, 2021
Rogelio A. Hernandez-Lopez, PhD, University of California, San Francisco
Track: Next-Generation Cellular Therapeutics for Cancer

Tuesday
Meet the Editors Roundtable
01:30pm - 02:30pm Eastern - January 26, 2021
Zeljko Durdevic, PhD, Panelist, EMBO Press; Sarah Hamilton, PhD, Panelist, Cell Reports Medicine; Claudia G. Willmes, Panelist, Cell Press
Track: Meet the Editors Roundtable

Beyond Effector T Cell Therapeutics
05:00pm - 08:00pm Eastern - January 26, 2021 | Room: Multi Tech Session
Saar I. Gill, PhD, Co-Chair, University of Pennsylvania; Megan K. Levings, PhD, Co-Chair, University of British Columbia
Track: Beyond Effector T Cell Therapeutics

Tuesday
Engineered Macrophage Therapeutics
05:00pm - 05:25pm Eastern - January 26, 2021 | Room: V300 Guy Coombes
Saar I. Gill, PhD, University of Pennsylvania
Track: Beyond Effector T Cell Therapeutics

Tuesday
NK Cell Therapies for Cancer
05:25pm - 05:50pm Eastern - January 26, 2021 | Room: V300 Guy Coombes
Dan S. Kaufman, MD, University of California, San Diego
Track: Beyond Effector T Cell Therapeutics

Tuesday
Programming Bacteria as a Cancer Therapy
05:50pm - 06:15pm Eastern - January 26, 2021 | Room: V300 Guy Coombes
Tal Danino, PhD, Columbia University
Track: Beyond Effector T Cell Therapeutics

Tuesday
NextGen Treg Therapies
06:40pm - 07:05pm Eastern - January 26, 2021
Megan K. Levings, PhD, University of British Columbia
Track: Beyond Effector T Cell Therapeutics

Tuesday
Synthetic Biology Tools for the Development of Engineered Stem Cell Therapeutics
07:05pm - 07:30pm Eastern - January 26, 2021
Tara L. Deans, PhD, University of Utah
Track: Beyond Effector T Cell Therapeutics

Tuesday

Engineering Materials for Cellular Therapeutics
10:00am - 01:00pm Eastern - January 27, 2021 | Room: Multi Tech Session
Darrell J. Irvine, PhD, Co-Chair, Massachusetts Institute of Technology; Tatiana Segura, PhD, Co-Chair, Duke University
Track: Engineering Materials for Cellular Therapeutics

Wednesday
Synthetic mRNA Nanocarriers for the in situ Programming of Disease-Specific Immune Cells
10:00am - 10:25am Eastern - January 27, 2021 | Room: V300 Guy Coombes
Matthias Stephan, PhD, Fred Hutchinson Cancer Research Center
Track: Engineering Materials for Cellular Therapeutics

Wednesday
Endogenous Immunity Primed by Vaccine-Boosted CAR T Cell Therapy
10:25am - 10:50am Eastern - January 27, 2021 | Room: V300 Guy Coombes
Darrell J. Irvine, PhD, Massachusetts Institute of Technology
Track: Engineering Materials for Cellular Therapeutics

Wednesday
Biomaterials for Tissue Repair and Regulation of Inflammation
10:50am - 11:15am Eastern - January 27, 2021 | Room: V300 Guy Coombes
Tatiana Segura, PhD, Duke University
Track: Engineering Materials for Cellular Therapeutics

Wednesday
Artificial APCs to Manufacture and Boost T Cell Therapies
11:35am - 12:00pm Eastern - January 27, 2021
David J. Mooney, PhD, Harvard University
Track: Engineering Materials for Cellular Therapeutics

Wednesday
Short Talk: High-Aspect Ratio Nano-Structures for Efficient, Minimally Perturbative and Transgene-Free Immuno-Transfection
12:00pm - 12:15pm Eastern - January 27, 2021
Andy Tay, PhD, National University of Singapore
Track: Engineering Materials for Cellular Therapeutics

Wednesday
Short Talk: Implantable Cell Therapy Platform With In Situ Pre-Vascularization and Localized Immunosuppression for Allogeneic Cell Transplantation
12:15pm - 12:30pm Eastern - January 27, 2021
Jesus Paez Mayorga, BS, Houston Methodist Hospital
Track: Engineering Materials for Cellular Therapeutics

Wednesday
Short Talk: Dual Targeting of Cancer and Suppressive Myeloid Cells by Tumor-Redirected iNKT Cells and Antigen-Carrying Microparticles
12:30pm - 12:45pm Eastern - January 27, 2021
Gloria Delfanti, PhD, San Raffaele Scientific Institute
Track: Engineering Materials for Cellular Therapeutics

Wednesday
Short Talk: Generalizable Computational Approach to Design Chemically Controlled Protein Switches with Multi-Logics for Cell-Based Therapeutics
12:45pm - 01:00pm Eastern - January 27, 2021
Sailan Shui, M.S., École polytechnique fédérale de Lausanne
Track: Engineering Materials for Cellular Therapeutics

Wednesday
Networking and Social Hour
03:00pm - 05:00pm Eastern - January 27, 2021
Track: Networking and Social Hour

Immune Cell Biology: Implications for Cellular Immunotherapy
05:00pm - 08:00pm Eastern - January 27, 2021 | Room: Multi Tech Session
Miriam Merad, MD, PhD, Co-Chair, Mount Sinai School of Medicine; Andrea Schietinger, PhD, Co-Chair, Memorial Sloan Kettering Cancer Center
Track: Immune Cell Biology: Implications for Cellular Immunotherapy

Wednesday
Myeloid Cell Contribution to Tumor Lesion Composition and Outcome
05:00pm - 05:25pm Eastern - January 27, 2021
Miriam Merad, MD, PhD, Mount Sinai School of Medicine
Track: Immune Cell Biology: Implications for Cellular Immunotherapy

Wednesday
Regulation of T Cell Function in Tumors
05:25pm - 05:50pm Eastern - January 27, 2021
Andrea Schietinger, PhD, Memorial Sloan Kettering Cancer Center
Track: Immune Cell Biology: Implications for Cellular Immunotherapy

Wednesday
NK Cells in Health and Disease
05:50pm - 06:15pm Eastern - January 27, 2021
Joseph C. Sun, PhD, Memorial Sloan Kettering Cancer Center
Track: Immune Cell Biology: Implications for Cellular Immunotherapy

Wednesday
Short Talk: Disrupting Enhancers within the Core Epigenetic Program of Exhaustion Improves CD8+ T Cell Responses and Enhances Tumor Control
06:45pm - 07:00pm Eastern - January 27, 2021 | Room: V200 Ronney Laws
Debattama Sen, PhD, Massachusetts General Hospital
Track: Immune Cell Biology: Implications for Cellular Immunotherapy

Wednesday
Short Talk: Mapping Cellular Interactions between Cancer and Normal Cells via Synthetic Notch Ligand/Receptor Pairs
07:00pm - 07:15pm Eastern - January 27, 2021 | Room: V200 Ronney Laws
Baris Avsaroglu, University of California, San Francisco
Track: Immune Cell Biology: Implications for Cellular Immunotherapy

Wednesday
Short Talk: Unbiased Design of Engineered T Cell Therapies Using Functional CRISPR/Cas9 Screens
07:15pm - 07:30pm Eastern - January 27, 2021 | Room: V200 Ronney Laws
Micah Benson, PhD, KSQ Therapeutics
Track: Immune Cell Biology: Implications for Cellular Immunotherapy

Wednesday
Short Talk: Uncovering the Cell-Type Specificity in Human T1D Immune Activation Using iPSC-beta Cells
07:30pm - 07:45pm Eastern - January 27, 2021 | Room: V200 Ronney Laws
Track: Immune Cell Biology: Implications for Cellular Immunotherapy

Wednesday
Closing Remarks
07:45pm - 08:00pm Eastern - January 27, 2021
Track: Closing Remarks