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Tuberculosis: Science Aimed at Ending the Epidemic

December 2-4, 2020 | 10:00AM ET | 3:00PM UTC*
*Program is subject to change


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Welcoming Remarks and Keynote Address
10:00am - 10:40am Eastern - December 2, 2020
Anne G. Kasmar, MD, Organizer, Genentech; Soumya Swaminathan, MD, World Health Organization
Track: Welcoming Remarks and Keynote Address

Wednesday
Taking Science‑Based Solutions to Scale
10:00am - 10:40am Eastern - December 2, 2020
Soumya Swaminathan, MD, World Health Organization
Track: Welcoming Remarks and Keynote Address

Breakthroughs in Biomarkers
10:40am - 01:20pm Eastern - December 2, 2020
Bruno B. Andrade, MD, PhD, Co-Chair, Oswaldo Cruz Foundation (FIOCRUZ); Mark Hatherill, MD, PhD, Co-Chair, University of Cape Town
Track: Breakthroughs in Biomarkers

Wednesday
Breakthroughs from Brazil and Beyond
10:40am - 11:05am Eastern - December 2, 2020
Bruno B. Andrade, MD, PhD, Oswaldo Cruz Foundation (FIOCRUZ)
Track: Breakthroughs in Biomarkers

Wednesday
Can Host Blood Transcriptomic Biomarkers of Tuberculosis Inform Therapy?
11:05am - 11:30am Eastern - December 2, 2020
Mark Hatherill, MD, PhD, University of Cape Town
Track: Breakthroughs in Biomarkers

Wednesday
Short Talk: Biomarkers to Predict Leprosy: it takes two…
11:30am - 11:42am Eastern - December 2, 2020
Annemieke Geluk, PhD, Leiden University Medical Center
Track: Breakthroughs in Biomarkers

Wednesday
Short Talk: Immune Correlates of Protection in Humans
11:42am - 11:54am Eastern - December 2, 2020
Elisa Nemes, PhD, University of Cape Town
Track: Breakthroughs in Biomarkers

Wednesday
Short Talk: GPX4 and BACH1 Regulate Necrotic Cell Death and Host Resistance in Mycobacterium Tuberculosis Infection in vivo
12:04pm - 12:16pm Eastern - December 2, 2020
Eduardo Pinheiro Amaral, PhD, NIAID, National Institutes of Health
Track: Breakthroughs in Biomarkers

Wednesday
Short Talk: Apparent Sterilizing Immunity in BCG‑Immunized Mice Challenged with an Ultra Low Dose of Mycobacterium tuberculosis
12:16pm - 12:28pm Eastern - December 2, 2020
Courtney R. Plumlee, PhD, Seattle Children's Research Institute
Track: Breakthroughs in Biomarkers

Wednesday
Short Talk: Host Immune Regulator PARP1 Drives TB Sex Differences
12:28pm - 12:40pm Eastern - December 2, 2020
William R. Bishai, MD, PhD, Johns Hopkins School of Medicine
Track: Breakthroughs in Biomarkers

Wednesday
Panel: COVID4TB
12:50pm - 01:20pm Eastern - December 2, 2020
Rodrigo Corrêa-Oliveira, PhD, Moderator, FIOCRUZ; Morten Ruhwald, MD, PhD, Panelist, FIND; Annette Vogel, DSc, Panelist, BioNTech; David Alland, MD, Panelist, Rutgers University, New Jersey Medical School
Track: Breakthroughs in Biomarkers

Wednesday
Career Roundtable
02:30pm - 03:30pm Eastern - December 2, 2020
Bryan D. Bryson, PhD, Panelist, Massachusetts Institute of Technology; Joao Monteiro, MD, PhD, Panelist, Nature Medicine; Lakshmi Ramachandra, PhD, Panelist, NIAID, National Institutes of Health
Track: Career Roundtable


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Bryan D. Bryson, Massachusetts Institute of Technology

Joao Monteiro, Nature Medicine

Lakshmi Ramachandra, NIAID, National Institutes of Health



Event Date/Time: Wednesday, December 2, 2:30–3:30PM EST

As part of our commitment to support and train the next generation of scientific leaders from all backgrounds, Keystone Symposia hosts Career Roundtables at selected in-person and virtual conferences. These workshops create a forum for field leaders to provide their unique perspectives on career development, professional pitfalls and the breadth of scientific opportunities available to support trainee scientists. Established researchers are chosen from a broad range of backgrounds (i.e., diverse demographics, career stages and career paths) to reflect a myriad of career paths and experiences. A panel discussion is followed by break out group sessions to enable trainees to interact with each senior scientist in a comfortable small group setting, to address specific questions, allow for mentorship and networking.

For More Information

For additional career advancement advice, see our Keypoint Blog "Words of Wisdom from Career Roundtables" with tips gleaned from past events on how to launch your career in academia, industry, publishing and beyond. Whether you are a student, post-doc, or early career investigator, check out these pearls of wisdom for all career stages!

Read the Blog


Highlights from the Host
05:00pm - 08:00pm Eastern - December 2, 2020
Katrin D. Mayer‑Barber, PhD, Co-Chair, NIAID, National Institutes of Health; Milton Ozório Moraes, PhD, Co-Chair, Oswaldo Cruz Institute‑ Fiocruz
Track: Highlights from the Host

Wednesday
Can Basic Immunology Solve Tuberculosis?
05:00pm - 05:25pm Eastern - December 2, 2020
Alan Sher, PhD, NIAID, National Institutes of Health
Track: Highlights from the Host

Wednesday
Mechanisms of Protection in Nonhuman Primates
05:25pm - 05:50pm Eastern - December 2, 2020
Patricia A. Darrah, PhD, NIAID, National Institutes of Health
Track: Highlights from the Host

Wednesday
Tricytotoxic CTLs in Leprosy and TB
05:50pm - 06:15pm Eastern - December 2, 2020
Robert L. Modlin, MD, University of California, Los Angeles
Track: Highlights from the Host

Wednesday
Unexpected Aspects of Granuloma Biology
06:35pm - 07:00pm Eastern - December 2, 2020
Katrin D. Mayer‑Barber, PhD, NIAID, National Institutes of Health
Track: Highlights from the Host

Wednesday
Short Talk: Autophagy and Host Metabolism in Leprosy
07:00pm - 07:12pm Eastern - December 2, 2020
Milton Ozório Moraes, PhD, Oswaldo Cruz Institute‑ Fiocruz
Track: Highlights from the Host

Wednesday


Abstract:


Intravenous BCG vaccination contributes to protection against Mtb via long-term remodeling of the pulmonary myeloid compartment

Alveolar macrophages are a major replicative niche for Mycobacterium tuberculosis (Mtb) and facilitate the entry of mycobacteria into the lung parenchyma. As such, alveolar macrophages are an attractive target for interventions aimed at preventing Mtb infection. Recent reports have described heightened anti-bacterial responses by myeloid cells in the bone marrow and blood of mice and humans vaccinated with BCG. However, it is unclear how BCG immunization affects tissue-resident myeloid populations. In the present study, we evaluated the long-term effects of BCG vaccination on alveolar macrophages in vivo. We used a BCG vaccination model in which mice were immunized via the intravenous (iv) route, previously shown to stimulate systemic inflammation and enhanced myelopoiesis in the bone marrow. In contrast to conventional subcutaneous (sc) BCG immunization, iv inoculation dramatically altered the composition of the myeloid cell compartment in the lung, triggering a striking, yet transient, depletion in alveolar macrophages that was dependent on IFNγ-producing T cells. The empty alveolar niche was subsequently re-populated by interferon-primed macrophages, likely derived from blood monocytes, that displayed heightened resistance to Mtb upon challenge 5 months after vaccination. Our results indicate that in promoting a robust Th1 response, systemic BCG immunization has a profound and long-term impact on lung-resident macrophages, affecting both their subset composition and responsiveness to microbial stimuli. This remodeling of the lung myeloid compartment may contribute to the enhanced protection against Mtb reported in experimental animals immunized with BCG via the iv route.

This research was supported by the Intramural Research Program of the NIAID, NIH.


Wednesday
Short Talk: GPR183 Oxysterol Axis Is Dysregulated at the Site of Disease during M. tuberculosis Infection
07:48pm - 08:00pm Eastern - December 2, 2020
Stacey Reanna Bartlett, PhD, Translational Research Institute–Mater Research Institute
Track: Highlights from the Host

Back to Bacterial Basics
10:00am - 01:00pm Eastern - December 3, 2020
Deborah T. Hung, MD, PhD, Co-Chair, Broad Institute of MIT & Harvard; Oyindamola Adefisayo, PhD, Co-Chair, Weill Cornell Medicine
Track: Back to Bacterial Basics

Thursday
The Biology of Metals in Mycobacterial Virulence and Antimycobacterial Immunity
10:00am - 10:25am Eastern - December 3, 2020
Olivier Neyrolles, PhD, IPBS, CNRS‑University of Toulouse
Track: Back to Bacterial Basics

Thursday
How MTB Sees the Host‑Pathogen Interface
10:25am - 10:50am Eastern - December 3, 2020
Track: Back to Bacterial Basics

Thursday
Short Talk: Live‑Imaging M. Leprae
10:50am - 11:02am Eastern - December 3, 2020
Cressida Madigan, PhD, University of California, San Diego
Track: Back to Bacterial Basics

Thursday
Targeting Adaptive Mycobacterial Translation as Anti‑Virulence Strategies
11:02am - 11:27am Eastern - December 3, 2020
Babak Javid, MD, PhD, University of California San Francisco
Track: Back to Bacterial Basics

Thursday
Mining PROSPECT for TB Drugs
11:47am - 12:12pm Eastern - December 3, 2020
Deborah T. Hung, MD, PhD, Broad Institute of MIT & Harvard
Track: Back to Bacterial Basics

Thursday
Short Talk: The Abundant Small Proteome of Mycobacterium tuberculosis
12:12pm - 12:24pm Eastern - December 3, 2020
Todd A. Gray, PhD, New York State Department of Health
Track: Back to Bacterial Basics

Thursday
Short Talk: Pseudogenization as a Source of Genetic Variability to the Mycobacterium tuberculosis Complex
12:24pm - 12:36pm Eastern - December 3, 2020
Naila Cristina Soler Camargo, BS, University of São Paulo
Track: Back to Bacterial Basics

Thursday
Short Talk: Functional Characterization of the Transcriptional Response to DNA Damage in Mycobacteria
12:36pm - 12:48pm Eastern - December 3, 2020
Oyindamola Adefisayo, PhD, Weill Cornell Medicine
Track: Back to Bacterial Basics

Thursday
Short Talk: Visualization of Dormancy Induced by Ribosome Hibernation in Zinc Starved Mycobacteria
12:48pm - 01:00pm Eastern - December 3, 2020
Jamie H. Corro, MS, State University of New York at Albany
Track: Back to Bacterial Basics

Thursday
Meet the Editors Roundtable
02:30pm - 03:30pm Eastern - December 3, 2020
Salvatore Fabbiano, PhD, Panelist, Cell Press; George Hills, Panelist, Sage Publishing; Zeljko Durdevic, PhD, Panelist, EMBO Press; Francesca Dickens, BS, Panelist, Frontiers
Track: Meet the Editors


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Salvatore Fabbiano, Cell Press’ “Med” Journal

George Hills, University Hospitals of Leicester NHS Trust

Zeljko Durdevic, EMBO Molecular Medicine

Francesca Dickens, Frontiers in Tropical Diseases



Event Date/Time: Thursday, December 3, 2:30–3:30PM EST

Meet-the-Editor panels are important aspects of both in-person and virtual Keystone Symposia meetings, designed to foster connections between editors and scientists. These mutually beneficial relationships help to facilitate the publication process for researchers, while providing editors insight into exciting new discoveries and research directions to showcase in upcoming journal issues. We encourage you to take advantage of this special session, and to reach out to these editors during the meeting, to get the inside scoop on fast-tracking your work for publication.

Join us for this 30-minute ePanel discussion followed by a 30-minute live Q/A, and ask these editors your burning questions!


Data to Drive Innovation
05:00pm - 08:00pm Eastern - December 3, 2020
Purvesh Khatri, PhD, Co-Chair, Stanford University; Shuyi Ma, PhD, Co-Chair, University of Washington
Track: Data to Drive Innovation

Thursday
Clonal Dynamics of the Antibody Response
05:00pm - 05:25pm Eastern - December 3, 2020
Gabriel D. Victora, PhD, Rockefeller University
Track: Data to Drive Innovation

Thursday
Multiscale Approaches Decipher the Many Faces of Altered Drug Susceptibility in Mycobacterium Tuberculosis
05:25pm - 05:50pm Eastern - December 3, 2020
Sarah M. Fortune, MD, Harvard TH Chan School of Public Health
Track: Data to Drive Innovation

Thursday
Adventures of a Data Parasite: Using Heterogeneity in "Dirty Data" to Accelerate Translational Medicine
05:50pm - 06:15pm Eastern - December 3, 2020
Purvesh Khatri, PhD, Stanford University
Track: Data to Drive Innovation

Thursday
Modeling Genetic Diversity in TB Susceptibility
06:30pm - 06:55pm Eastern - December 3, 2020
Christopher M. Sassetti, PhD, University of Massachusetts Medical School
Track: Data to Drive Innovation

Thursday
Tuberculosis Strain Diversity Drives Immune Response
06:55pm - 07:20pm Eastern - December 3, 2020
Shabaana Khader, PhD, Washington University School of Medicine
Track: Data to Drive Innovation

Thursday
Short Talk: Data‑Driven Inference of Drug Synergy
07:20pm - 07:32pm Eastern - December 3, 2020
Shuyi Ma, PhD, University of Washington
Track: Data to Drive Innovation

Thursday
Short Talk: Defining the Role of CD8 T Cell Subsets in Tuberculosis in Non Human Primates
07:32pm - 07:44pm Eastern - December 3, 2020
Caylin G. Winchell, PhD, University of Pittsburgh School of Medicine
Track: Data to Drive Innovation

Thursday
Short Talk: Mycobacterium tuberculosis VapC4 Toxin Engages Small ORFs to Initiate an Integrated Oxidative and Copper Stress Response
07:44pm - 07:56pm Eastern - December 3, 2020
Valdir C. Barth, PhD, Boston Children's Hospital
Track: Data to Drive Innovation

Rethinking Risk in TB
10:00am - 01:00pm Eastern - December 4, 2020
Julio Croda, PhD, Co-Chair, Oswaldo Cruz Foundation / Federal University of Mato Grosso do Sul / Yale School; Sara Suliman, PhD, Co-Chair, Brigham and Women's Hospital
Track: Rethinking Risk in TB

Friday
Transmission is Driving the TB Epidemic, but Where Is the Majority of Transmission Occurring?
10:00am - 10:25am Eastern - December 4, 2020
Neel R. Gandhi, MD, Emory University
Track: Rethinking Risk in TB

Friday
Tuberculosis in Prisons: Spillover and Impact in the Community
10:25am - 10:50am Eastern - December 4, 2020
Julio Croda, PhD, Oswaldo Cruz Foundation / Federal University of Mato Grosso do Sul / Yale School
Track: Rethinking Risk in TB

Friday
Mtb Transmissibility and Tissue Response
10:50am - 11:15am Eastern - December 4, 2020
Padmini Salgame, PhD, Rutgers University
Track: Rethinking Risk in TB

Friday
A Focus on Bacterial Factors
11:35am - 12:00pm Eastern - December 4, 2020
Kyu Y. Rhee, MD, Weill Cornell Medical College
Track: Rethinking Risk in TB

Friday
Short Talk: Integration of Genetic and Transcriptional Profiles of Innate Cells to Decipher Mechanisms of TB Susceptibility
12:00pm - 12:12pm Eastern - December 4, 2020
Sara Suliman, PhD, Brigham and Women's Hospital
Track: Rethinking Risk in TB

Friday

Friday
Short Talk: CryoEM Structure of an Mce/YrbE ABC Transporter Complex Sheds Light on Hydrophobic Transport across the Envelope
12:48pm - 01:00pm Eastern - December 4, 2020
Damian C. Ekiert, PhD, New York University School of Medicine
Track: Rethinking Risk in TB

Directing Discovery to Transform TB
05:00pm - 08:15pm Eastern - December 4, 2020
David Alland, MD, Co-Chair, Rutgers University, New Jersey Medical School; Stefanie Krug, PhD, Co-Chair, Johns Hopkins University School of Medicine
Track: Directing Discovery to Transform TB

Friday
Short Talk: BCG for COVID
05:00pm - 05:12pm Eastern - December 4, 2020
Mihai G. Netea, MD, Radboud University
Track: Directing Discovery to Transform TB

Friday
LTBI Management in Mainland China
05:12pm - 05:37pm Eastern - December 4, 2020
Lei Gao, PhD, Chinese Academy of Medical Sciences
Track: Directing Discovery to Transform TB

Friday
Taming Tuberculosis: The Path from Pathogen to Commensal
05:37pm - 06:02pm Eastern - December 4, 2020
Yasmine Belkaid, PhD, NIAID, National Institutes of Health
Track: Directing Discovery to Transform TB

Friday
Emerging Results from Next Gen EBA Studies
06:02pm - 06:27pm Eastern - December 4, 2020
Clifton E. Barry III, PhD, NIAID, National Institutes of Health
Track: Directing Discovery to Transform TB

Friday
Ending TB in the Next 15 Years: Can We Do It, Using the Tools We Have Now, Better?
06:27pm - 06:49pm Eastern - December 4, 2020
Guy B. Marks, PhD, University of New South Wales
Track: Directing Discovery to Transform TB

Friday
Short Talk: Pyrazinamide Inhibits the Host Enzyme PARP1 to Reduce Inflammation and Accelerate Bacterial Clearance
07:10pm - 07:22pm Eastern - December 4, 2020
Stefanie Krug, PhD, Johns Hopkins University School of Medicine
Track: Directing Discovery to Transform TB

Friday
Short Talk: A Donor‑Unrestricted TCR‑Bispecific Redirects T Cell Immunity Against Mycobacterium tuberculosis via HLA E
07:22pm - 07:34pm Eastern - December 4, 2020
Sarah Leonard, PhD, Immunocore Ltd
Track: Directing Discovery to Transform TB

Friday
Short Talk: An Anti‑Viral Vaccine Regimen that Leverages Mycobacteria Specific Helper T Cells Induced by Prior BCG Vaccination
07:34pm - 07:45pm Eastern - December 4, 2020
Tony W. Ng, PhD, Albert Einstein College of Medicine
Track: Directing Discovery to Transform TB

Friday
Closing Keynote Address: Turning Discoveries into Useful Tools
07:45pm - 08:15pm Eastern - December 4, 2020
David Alland, MD, Rutgers University, New Jersey Medical School
Track: Directing Discovery to Transform TB