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Autophagy: Mechanisms and Disease

October 5-8, 2020 | 8:00AM EDT | 12:00PM UTC*
*Program is in development and subject to change


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Welcoming Remarks and Keynote Address
08:00am - 08:35am Eastern - October 5, 2020
Patricia Boya, PhD, Organizer, Centro de Investigaciones Biológicas, CSIC; Eric H. Baehrecke, PhD, University of Massachusetts Medical School
Track: Opening Remarks and Keynote Address

Monday
Autophagy, Mitochondria and Disease
08:05am - 08:35am Eastern - October 5, 2020
Eric H. Baehrecke, PhD, University of Massachusetts Medical School
Track: Keynote Address: Beth Levine Lecture

Mini Symposium to Honor Beth Levine
08:35am - 09:45am Eastern - October 5, 2020
Patricia Boya, PhD, Co-Chair, Centro de Investigaciones Biológicas, CSIC; Eric H. Baehrecke, PhD, Co-Chair, University of Massachusetts Medical School
Track: Mini Symposium to Honor Beth Levine

Monday
Panel | Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship
08:35am - 09:00am Eastern - October 5, 2020
Herbert (Skip) W. Virgin, MD, PhD, Vir Biotechnology; Ana Maria Cuervo, PhD, MD, Albert Einstein College of Medicine; Malene Hansen, PhD, Sanford Burnham Prebys Medical Discovery Institute
Track: Mini Symposium to Honor Beth Levine

Monday
Short Talk: Role of Sorting Nexins in Virophagy
09:00am - 09:15am Eastern - October 5, 2020
Xiaonan Dong, PhD, University of Texas Southwestern Medical Center
Track: Mini Symposium to Honor Beth Levine

Monday
Short Talk: Crosstalk between TLR9 and Beclin 1 in Muscle
09:15am - 09:30am Eastern - October 5, 2020
Yang Liu, PhD, University of Texas Southwestern Medical Center
Track: Mini Symposium to Honor Beth Levine

Monday
Short Talk: Role of Autophagy and Beclin 1 in Aging
09:30am - 09:45am Eastern - October 5, 2020
Salwa Sebti, PhD, University of Texas Southwestern Medical Center
Track: Mini Symposium to Honor Beth Levine

New Insights into the Molecular Regulation of Autophagy
10:00am - 12:00pm Eastern - October 5, 2020
Felix Randow, PhD, Co-Chair, Medical Research Council; Fulvio Reggiori, PhD, Co-Chair, University Medical Centre Groningen
Track: New Insights into the Molecular Regulation of Autophagy

Monday
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy
10:00am - 10:25am Eastern - October 5, 2020
David C. Rubinsztein, MD, PhD, Cambridge Institute for Medical Research
Track: New Insights into the Molecular Regulation of Autophagy

Monday
Molecular Regulation of Autophagosome Formation
10:25am - 10:50am Eastern - October 5, 2020
Fulvio Reggiori, PhD, University Medical Centre Groningen
Track: New Insights into the Molecular Regulation of Autophagy

Monday
Molecular Mechanism of Large‑Scale Organelle Degradation in the Lens
10:50am - 11:15am Eastern - October 5, 2020
Noboru Mizushima, MD, PhD, University of Tokyo
Track: New Insights into the Molecular Regulation of Autophagy

Monday
Short Talk: Amyloid beta Modulates Neuronal Autophagy through the Primary Cilium
11:15am - 11:30am Eastern - October 5, 2020
Olatz Pampliega, PhD, Achucarro Basque Center for Neuroscience
Track: New Insights into the Molecular Regulation of Autophagy

Monday
Short Talk: Reconstituting Cargo Triggered LC3 Lipidation in Autophagy
11:30am - 11:45am Eastern - October 5, 2020
Chunmei Chang, PhD, University of California, Berkeley
Track: New Insights into the Molecular Regulation of Autophagy

Monday
Short Talk: Examining the Regulation of Autophagy via Identification and Characterisation of ULK Kinase Substrates
11:45am - 12:00pm Eastern - October 5, 2020
Thomas Mercer, PhD, Francis Crick Institute
Track: New Insights into the Molecular Regulation of Autophagy

Selective and Non‑Canonical Autophagy
08:00am - 12:00pm Eastern - October 6, 2020
Richard J. Youle, PhD, Co-Chair, NINDS, National Institutes of Health; Anne Simonsen, PhD, Co-Chair, University of Oslo
Track: Selective and Non‑Canonical Autophagy

Tuesday
[Talk Postponed] Chaperone Mediated Autophagy
08:00am - 08:25am Eastern - October 6, 2020
Ana Maria Cuervo, PhD, MD, Albert Einstein College of Medicine
Track: Selective and Non‑Canonical Autophagy

Tuesday
Mitophagy
08:00am - 08:25am Eastern - October 6, 2020
Richard J. Youle, PhD, NINDS, National Institutes of Health
Track: Selective and Non‑Canonical Autophagy

Tuesday
Regulation of Autophagy by Lipid‑Binding Proteins
08:25am - 08:50am Eastern - October 6, 2020
Anne Simonsen, PhD, University of Oslo
Track: Selective and Non‑Canonical Autophagy

Tuesday
Combined Targeting of RAS Signaling Plus Autophagy as a Future Treatment Strategy for Cancer
08:50am - 09:15am Eastern - October 6, 2020
Martin McMahon, PhD, University of Utah School of Medicine
Track: Selective and Non‑Canonical Autophagy

Tuesday
New Links between Autophagy and Developmental Cell Death
09:40am - 10:05am Eastern - October 6, 2020
Patricia Boya, PhD, Centro de Investigaciones Biológicas, CSIC
Track: Selective and Non‑Canonical Autophagy

Tuesday
Non‑Canonical Autophagy Mediates Immunotolerant Mechanisms
10:05am - 10:30am Eastern - October 6, 2020
Jennifer Martinez, PhD, NIEHS, National Institutes of Health
Track: Selective and Non‑Canonical Autophagy

Tuesday
Short Talk: Aging Represses Autophagosome Biogenesis but not Autophagosome Transport or Maturation in Neurons
10:30am - 10:45am Eastern - October 6, 2020
Andrea KH Stavoe, PhD, University of Texas Health Science Center at Houston
Track: Selective and Non‑Canonical Autophagy

Tuesday
Short Talk: Autophagy and Lysosomal Degradation Ensure Accurate Chromosomal Segregation to Prevent Genomic Instability
10:45am - 11:00am Eastern - October 6, 2020
Track: Selective and Non‑Canonical Autophagy

Tuesday
Short Talk: Receptor‑Mediated Clustering of FIP200 Bypasses the Role of LC3 Lipidation in Autophagy
11:00am - 11:15am Eastern - October 6, 2020
Chris Shoemaker, PhD, Dartmouth College
Track: Selective and Non‑Canonical Autophagy

Tuesday
Short Talk: Selective Autophagy of NEK9 Regulates Primary Cilia Formation
11:15am - 11:30am Eastern - October 6, 2020
Yasuhiro Yamamoto, MD, University of Tokyo
Track: Selective and Non‑Canonical Autophagy

Tuesday
Meet the Editors Roundtable
01:00pm - 02:00pm Eastern - October 6, 2020
Sadaf Shadan, PhD, Panelist, Nature; Stella M. Hurtley, PhD, Panelist, Science; Elisabetta Argenzio, PhD, Panelist, EMBO Journal; Petra Gross, PhD, Panelist, The Company of Biologists
Track: Meet the Editors Roundtable


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Sadaf Shadan, Nature

Stella Hurtley, Science

Elisabetta Argenzio, EMBO

Petra Gross, Journal of Cell Science


Event Date/Time: Tuesday, October 6, 1:00–2:00PM ET

Meet-the-Editor panels are important aspects of both in-person and virtual Keystone Symposia meetings, designed to foster connections between editors and scientists. These mutually beneficial relationships help to facilitate the publication process for researchers, while providing editors insight into exciting new discoveries and research directions to showcase in upcoming journal issues. We encourage you to take advantage of this special session, and to reach out to these editors during the meeting, to get the inside scoop on fast-tracking your work for publication.

Join us for this 30-minute ePanel discussion followed by a 30-minute live Q/A, and ask these editors your burning questions!


Autophagy and Organelle Crosstalk
08:00am - 11:40am Eastern - October 7, 2020
Alicia Melendez, PhD, Co-Chair, Queens College ‑ CUNY; Masaaki Komatsu, PhD, Co-Chair, Juntendo University School of Medicine
Track: Autophagy and Organelle Crosstalk

Wednesday
ER‑Phagy
08:00am - 08:25am Eastern - October 7, 2020
Ivan Dikic, MD, PhD, Goethe University Medical School
Track: Autophagy and Organelle Crosstalk

Wednesday
Autophagy in Germline Development
08:25am - 08:50am Eastern - October 7, 2020
Alicia Melendez, PhD, Queens College ‑ CUNY
Track: Autophagy and Organelle Crosstalk

Wednesday
Emerging New Roles of Lysosomes in Cellular Response to Stress
08:50am - 09:15am Eastern - October 7, 2020
Rosa Puertollano, PhD, NHLBI, National Institutes of Health
Track: Autophagy and Organelle Crosstalk

Wednesday
Autophagy and Bacterial Infection
09:15am - 09:40am Eastern - October 7, 2020
Felix Randow, PhD, Medical Research Council
Track: Autophagy and Organelle Crosstalk

Wednesday
Regulation of WIPI Beta‑Propeller Function in Autophagy
10:05am - 10:30am Eastern - October 7, 2020
Tassula Proikas Cezanne, PhD, University of Tuebingen
Track: Autophagy and Organelle Crosstalk

Wednesday
ER‑phagy Mediated by the Ufm1‑System
10:30am - 10:55am Eastern - October 7, 2020
Masaaki Komatsu, PhD, Juntendo University School of Medicine
Track: Autophagy and Organelle Crosstalk

Wednesday
Short Talk: Selective Autophagy of the Endoplasmic Reticulum (ER‑phagy): From Cellular Functions to Signalling Regulation
10:55am - 11:10am Eastern - October 7, 2020
Carmine Settembre, PhD, Telethon Foundation
Track: Autophagy and Organelle Crosstalk

Wednesday
Short Talk: Live and Quantitative Imaging Reveals in vivo Dynamics and Molecular Basis of Physiological Stress Induced Mitophagy
11:10am - 11:25am Eastern - October 7, 2020
Paul J. Wrighton, PhD, Brigham and Women's Hospital
Track: Autophagy and Organelle Crosstalk

Wednesday
Short Talk: Atg4 Family Proteins Drive Phagophore Growth Independently of LC3/GABARAP Lipidation System
11:25am - 11:40am Eastern - October 7, 2020
Thanh N. Nguyen, PhD, Monash University
Track: Autophagy and Organelle Crosstalk

Wednesday
Career Roundtable
02:00pm - 03:00pm Eastern - October 7, 2020
Jennifer Martinez, PhD, Panelist, NIEHS, National Institutes of Health; Alicia Melendez, PhD, Panelist, Queens College ‑ CUNY; Leon O. Murphy, PhD, Panelist, Casma Therapeutics
Track: Career Roundtable
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Jennifer Martinez, NIEHS, National Institutes of Health

Alicia Melendez, Queens College - CUNY

Leon O. Murphy, Casma Therapeutics


Event Date/Time: Wednesday, October 7, 2:00–3:00PM ET

As part of our commitment to support and train the next generation of scientific leaders from all backgrounds, Keystone Symposia hosts Career Roundtables at selected in-person and virtual conferences. These workshops create a forum for field leaders to provide their unique perspectives on career development, professional pitfalls and the breadth of scientific opportunities available to support trainee scientists. Established researchers are chosen from a broad range of backgrounds (i.e., diverse demographics, career stages and career paths) to reflect a myriad of career paths and experiences. A panel discussion is followed by break out group sessions to enable trainees to interact with each senior scientist in a comfortable small group setting, to address specific questions, allow for mentorship and networking.


Autophagy and Disease, New Therapeutic Opportunities
08:00am - 12:00pm Eastern - October 8, 2020
Patricia Boya, PhD, Co-Chair, Centro de Investigaciones Biológicas, CSIC; Martin Graef, PhD, Co-Chair, Max Planck Institute for Biology of Aging
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
Autophagy and Obesity
08:00am - 08:25am Eastern - October 8, 2020
Guido Kroemer, MD, PhD, Cordeliers Research Center
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
Cell‑Extrinsic Role of Autophagy in Inflammation
08:25am - 08:50am Eastern - October 8, 2020
Katja Simon, PhD, University of Oxford
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Regulate Autophagy Activity
08:50am - 09:15am Eastern - October 8, 2020
Hong Zhang, PhD, Chinese Academy of Sciences
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
Autophagy and Cellular Aging
09:15am - 09:40am Eastern - October 8, 2020
Martin Graef, PhD, Max Planck Institute for Biology of Aging
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
New Mechanistic Insight into the Regulation of TFEB at the Lysosome
10:10am - 10:35am Eastern - October 8, 2020
Leon O. Murphy, PhD, Casma Therapeutics
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
New Therapies for Infectious Diseases
10:35am - 11:00am Eastern - October 8, 2020
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
Short Talk: Multiplexed Proteomics in Macrophages Uncovers Novel Roles of Autophagy in Anti Microbial Immunity
11:00am - 11:15am Eastern - October 8, 2020
Aditya Murthy, PhD, Genentech, Inc.
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
Short Talk: A Cross‑Kingdom Conserved ER‑Phagy Receptor Maintains Endoplasmic Reticulum Homeostasis during Stress
11:15am - 11:30am Eastern - October 8, 2020
Yasin Dagdas, PhD, Gregor Mendel Institute
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
Short Talk: Autophagy Compensates for Lkb1 Loss to Maintain Adult Mice Homeostasis and Survival
11:30am - 11:45am Eastern - October 8, 2020
Yanxiang (Jessie) Guo, PhD, Rutgers University
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
Short Talk: The Primary Cilium and Lipophagy Translate Mechanical Forces to Direct Metabolic Adaptation of Kidney Epithelial Cells
11:45am - 12:00pm Eastern - October 8, 2020
Nicolas Dupont, PhD, Université de Paris, INSERM U1151
Track: Autophagy and Disease, New Therapeutic Opportunities

Thursday
Closing Remarks (Organizers)
12:00pm - 12:10pm Eastern - October 8, 2020
Patricia Boya, PhD, Organizer, Centro de Investigaciones Biológicas, CSIC; Felix Randow, PhD, Organizer, Medical Research Council; Masaaki Komatsu, PhD, Organizer, Juntendo University School of Medicine