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Tissue Plasticity:
Preservation and Alteration of Cellular Identity

October 5-7, 2020 | 10:00AM EDT | 2:00PM UTC*
*Program is in development and subject to change


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Opening Remarks and Keynote Address
10:00am - 10:40am Eastern - October 5, 2020
Ophir Klein, MD, PhD, Organizer, University of California, San Francisco; Magdalena D. Zernicka‑Goetz, PhD, Caltech and University of Cambridge
Track: Opening Remarks and Keynote Address

Monday
Developmental Plasticity, Cell Fate Specification and Morphogenesis in the Early Mouse and Human Embryo
10:00am - 10:40am Eastern - October 5, 2020
Magdalena D. Zernicka‑Goetz, PhD, Caltech and University of Cambridge
Track: Opening Remarks and Keynote Address

Plasticity in the Early Embryo
10:40am - 12:50pm Eastern - October 5, 2020
Daniel Klimmeck, PhD, Co-Chair, EMBO Journal; Ramesh A. Shivdasani, MD, PhD, Co-Chair, Dana‑Farber Cancer Institute
Track: Plasticity in the Early Embryo

Monday
Cell Plasticity in Development and Disease
10:40am - 11:05am Eastern - October 5, 2020
Angela Nieto, PhD, Instituto de Neurociencias de Alicante, CSIC‑UMH, Spain
Track: Plasticity in the Early Embryo

Monday
A Single Cell Road Map of Foregut Progenitors Identity
11:30am - 11:55am Eastern - October 5, 2020
Aaron M. Zorn, PhD, Cincinnati Children's Hospital Medical Center
Track: Plasticity in the Early Embryo

Monday
Short Talk: Reprogramming Axial Level Identity to Rescue Neural‑Crest‑Related Congenital Heart Defects
12:20pm - 12:32pm Eastern - October 5, 2020
Shashank Gandhi, MS, California Institute of Technology
Track: Plasticity in the Early Embryo

Monday
Panel Discussion with Speakers
12:32pm - 12:50pm Eastern - October 5, 2020
Track: Plasticity in the Early Embryo

Monday
Career Roundtable
02:30pm - 03:30pm Eastern - October 5, 2020
Shingo Kajimura, PhD, Panelist, University of California, San Francisco; Juanita L. Merchant, MD, PhD, Panelist, University of Arizona College of Medicine; Qing Sara Lin, PhD, Panelist, NHLBI, National Institutes of Health
Track: Career Roundtable
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Shingo Kajimura, University of California, San Francisco

Juanita L. Merchant, University of Arizona College of Medicine

Qing Sara Lin, NHLBI, National Institutes of Health


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Event Date/Time: Monday, October 5, 2:30–3:30PM ET

As part of our commitment to support and train the next generation of scientific leaders from all backgrounds, Keystone Symposia hosts Career Roundtables at selected in-person and virtual conferences. These workshops create a forum for field leaders to provide their unique perspectives on career development, professional pitfalls and the breadth of scientific opportunities available to support trainee scientists. Established researchers are chosen from a broad range of backgrounds (i.e., diverse demographics, career stages and career paths) to reflect a myriad of career paths and experiences. A panel discussion is followed by break out group sessions to enable trainees to interact with each senior scientist in a comfortable small group setting, to address specific questions, allow for mentorship and networking.

For More Information

For additional career advancement advice, see our Keypoint Blog "Words of Wisdom from Career Roundtables" with tips gleaned from past events on how to launch your career in academia, industry, publishing and beyond. Whether you are a student, post-doc, or early career investigator, check out these pearls of wisdom for all career stages!

Read the Blog


Tissue Plasticity from Invertebrates to Vertebrates
05:00pm - 08:00pm Eastern - October 5, 2020
Misty Riddle, PhD, Co-Chair, Blavatnik Institute, Harvard Medical School; Kathleen DelGiorno, Co-Chair, Vanderbilt University
Track: Tissue Plasticity from Invertebrates to Vertebrates

Monday
Fate Choices in Lung Development
05:00pm - 05:25pm Eastern - October 5, 2020
Xin Sun, PhD, University of California, San Diego
Track: Tissue Plasticity from Invertebrates to Vertebrates

Monday
Ablation and Replacement of Fly Stem Cells: Plasticity in the Epithelium
05:25pm - 05:50pm Eastern - October 5, 2020
Leanne Jones, PhD, University of California, Los Angeles
Track: Tissue Plasticity from Invertebrates to Vertebrates

Monday
Skeletal Stem Cells and GPCR Signaling
05:50pm - 06:15pm Eastern - October 5, 2020
Yingzi Yang, PhD, Harvard School of Dental Medicine
Track: Tissue Plasticity from Invertebrates to Vertebrates

Monday
Amitosis and Plasticity
06:40pm - 07:05pm Eastern - October 5, 2020
Benjamin Ohlstein, MD, PhD, UT Southwestern Medical Center
Track: Tissue Plasticity from Invertebrates to Vertebrates

Monday
Plasticity and Regeneration in the Intestinal Crypt
07:05pm - 07:30pm Eastern - October 5, 2020
Ophir Klein, MD, PhD, University of California, San Francisco
Track: Tissue Plasticity from Invertebrates to Vertebrates

Monday
Short Talk: Genetic Chimerism Causes Regeneration Defects in the Planarian
07:30pm - 07:42pm Eastern - October 5, 2020
Bo Wang, PhD, Stanford University
Track: Tissue Plasticity from Invertebrates to Vertebrates

Monday
Panel Discussion with Speakers
07:42pm - 08:00pm Eastern - October 5, 2020
Track: Tissue Plasticity from Invertebrates to Vertebrates

Epigenetics, Transcription and Plasticity
10:00am - 12:45pm Eastern - October 6, 2020
Michal Shoshkes-Carmel, PhD, Co-Chair, Hebrew University; Frederic Michon, PhD, Co-Chair, Hopital Saint Eloi
Track: Epigenetics, Transcription and Plasticity

Tuesday
Molecular Control of Fat and Muscle Plasticity
10:00am - 10:25am Eastern - October 6, 2020
Shingo Kajimura, PhD, University of California, San Francisco
Track: Epigenetics, Transcription and Plasticity

Tuesday
All Aboard: Adipocyte Function in Tissue Repair
10:25am - 10:50am Eastern - October 6, 2020
Valerie Horsley, PhD, Yale University
Track: Epigenetics, Transcription and Plasticity

Tuesday
Tissue Plasticity in a Human Disease: The Enigma of Barrett’s Metaplasia
10:50am - 11:15am Eastern - October 6, 2020
Ramesh A. Shivdasani, MD, PhD, Dana‑Farber Cancer Institute
Track: Epigenetics, Transcription and Plasticity

Tuesday
Chromatin Regulation of Skin Development and Skin Stem Cells
11:40am - 12:05pm Eastern - October 6, 2020
Elena Ezhkova, PhD, Icahn School of Medicine at Mount Sinai
Track: Epigenetics, Transcription and Plasticity

Tuesday
Short Talk: The Role of Histone Inheritance in Establishing Distinct Cell Identities
12:05pm - 12:17pm Eastern - October 6, 2020
Emily Zion, BS, Johns Hopkins University
Track: Epigenetics, Transcription and Plasticity

Tuesday
Short Talk: Vascular Smooth Muscle‑Derived Adipocyte Progenitors are the Cellular Origin of Cold Induced Brown Adipocytes
12:17pm - 12:29pm Eastern - October 6, 2020
Farnaz Shamsi, PhD, Joslin Diabetes Center
Track: Epigenetics, Transcription and Plasticity

Tuesday
Panel Discussion with Speakers
12:29pm - 12:45pm Eastern - October 6, 2020
Track: Epigenetics, Transcription and Plasticity

Inflammation, Renewal and Plasticity
05:00pm - 07:45pm Eastern - October 6, 2020
Nadya L. Lumelsky, PhD, Co-Chair, NIDCR, National Institutes of Health; Ophir Klein, MD, PhD, Co-Chair, University of California, San Francisco
Track: Inflammation, Renewal and Plasticity

Tuesday
Gut Inflammation in Disease
05:00pm - 05:25pm Eastern - October 6, 2020
Juanita L. Merchant, MD, PhD, University of Arizona College of Medicine
Track: Inflammation, Renewal and Plasticity

Tuesday
Regulation of Urothelial Plasticity and Regeneration
05:25pm - 05:50pm Eastern - October 6, 2020
Indira U. Mysorekar, PhD, Washington University School of Medicine
Track: Inflammation, Renewal and Plasticity

Tuesday
Hepatic Epithelial Cell Plasticity
05:50pm - 06:15pm Eastern - October 6, 2020
Stacey S. Huppert, PhD, Cincinnati Children’s Hospital Medical Center
Track: Inflammation, Renewal and Plasticity

Tuesday
Eavesdropping on the Conversation between Immune and Epithelial Stem Cells during Tissue Repair
06:40pm - 07:05pm Eastern - October 6, 2020
Shruti Naik, PhD, New York University
Track: Inflammation, Renewal and Plasticity

Tuesday
Epithelial Plasticity in Development and Tissue Regeneration
07:05pm - 07:30pm Eastern - October 6, 2020
Edward E. Morrisey, PhD, University of Pennsylvania
Track: Inflammation, Renewal and Plasticity

Tuesday
Panel Discussion with Speakers
07:30pm - 07:45pm Eastern - October 6, 2020
Track: Inflammation, Renewal and Plasticity

Cancer Stem Cells and Their Niche
10:00am - 01:00pm Eastern - October 7, 2020
Jonathan Saxe, PhD, Co-Chair, Cell Press; Stacey S. Huppert, PhD, Co-Chair, Cincinnati Children’s Hospital Medical Center
Track: Cancer Stem Cells and Their Niche

Wednesday
How Blood Ages
10:00am - 10:25am Eastern - October 7, 2020
Emmanuelle Passegué, PhD, Columbia University
Track: Cancer Stem Cells and Their Niche

Wednesday
Role of the Extracellular Matrix in Niche Construction
10:25am - 10:50am Eastern - October 7, 2020
Valerie M. Weaver, PhD, University of California, San Francisco
Track: Cancer Stem Cells and Their Niche

Wednesday
Differentiated Cells Undergo Metaplasia and Tumorigenesis via Paligenosis
10:50am - 11:15am Eastern - October 7, 2020
Jason C. Mills, MD, PhD, Washington University
Track: Cancer Stem Cells and Their Niche

Wednesday
EMT and Cellular Plasticity in Cancer
11:35am - 12:00pm Eastern - October 7, 2020
Ben Z. Stanger, MD, PhD, University of Pennsylvania
Track: Cancer Stem Cells and Their Niche

Wednesday
Short Talk: The Plasticity of Liver Epithelial Cells during Homeostasis, Regeneration and Tumor Formation
12:00pm - 12:12pm Eastern - October 7, 2020
Tianliang Sun, PhD, Novartis Institutes for BioMedical Research
Track: Cancer Stem Cells and Their Niche

Wednesday
Short Talk: Loss of TSC1 or TSC2 Drives Lineage Infidelity and Hamartoma Formation in a Renal Organoid Model of Angiomyolipoma
12:12pm - 12:24pm Eastern - October 7, 2020
Adam Pietrobon, BS, Ottawa Hospital Research Institute
Track: Cancer Stem Cells and Their Niche

Wednesday
Short Talk: Autophagy Drives in vivo Transdifferentiation
12:24pm - 12:36pm Eastern - October 7, 2020
Rashmi Mishra, PhD, Sanford Burnham Prebys Medical Discovery Institute
Track: Cancer Stem Cells and Their Niche

Wednesday
Panel Discussion with Speakers
12:36pm - 12:50pm Eastern - October 7, 2020
Track: Cancer Stem Cells and Their Niche

Wednesday
Closing Remarks (Organizers)
12:50pm - 01:00pm Eastern - October 7, 2020
Ophir Klein, MD, PhD, Organizer, University of California, San Francisco; Ramesh A. Shivdasani, MD, PhD, Organizer, Dana‑Farber Cancer Institute; Stacey S. Huppert, PhD, Organizer, Cincinnati Children’s Hospital Medical Center
Track: Closing Remarks (Organizers)