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RNA Editing and Modifications: From Biology to Therapy

Sept. 30-Oct. 2, 2020 | 10:00AM EDT | 2:00PM UTC*
*Program is in development and subject to change


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Organizer Introduction and Keynote Address
10:00am - 10:45am Eastern - September 30, 2020
Jin Billy Li, PhD, Co-Chair, Stanford University, USA; Stacy M. Horner, PhD, Co-Chair, Duke University Medical Center; Chuan He, PhD, University of Chicago, USA

Wednesday
Organizer Introduction
10:00am - 10:05am Eastern - September 30, 2020
Jin Billy Li, PhD, Co-Chair, Stanford University, USA

Wednesday
Keynote Address | Reversible RNA Methylation in Gene Expression Regulation
10:05am - 10:45am Eastern - September 30, 2020
Stacy M. Horner, PhD, Chair, Duke University Medical Center; Chuan He, PhD, University of Chicago, USA
Track: Keynote Address

Dynamic Regulation of the Epitranscriptome
10:45am - 01:00pm Eastern - September 30, 2020
Blerta Xhemalce, PhD, Co-Chair, University of Texas, Austin, USA; Polly Chen, PhD, Co-Chair, National University of Singapore, Singapore
Track: Dynamic Regulation of the Epitranscriptome

Wednesday
Targeting RNA Methylation in Cancer
10:45am - 11:15am Eastern - September 30, 2020
Blerta Xhemalce, PhD, University of Texas, Austin, USA
Track: Dynamic Regulation of the Epitranscriptome

Wednesday
Short Talk: Dynamic RNA Acetylation as a Mechanism for RNA Thermostabilization
11:15am - 11:35am Eastern - September 30, 2020
Aldema Sas-Chen, PhD, Weizmann Institute of Science
Track: Dynamic Regulation of the Epitranscriptome

Wednesday
ADAR1 RNA Editing and Innate Immunity
11:50am - 12:20pm Eastern - September 30, 2020
Jin Billy Li, PhD, Stanford University, USA
Track: Dynamic Regulation of the Epitranscriptome

Wednesday
Short Talk: Lack of m5U Modification in tRNAs Induces the Formation of tRNA-Derived Fragments
12:20pm - 12:40pm Eastern - September 30, 2020
Marisa Almeida Pereira, PhD, iBiMED-Institute of Biomedicine, Portugal
Track: Dynamic Regulation of the Epitranscriptome

Wednesday
Short Talk: Dynamic Regulation of A-to-I RNA Editing by RNA Helicases
12:40pm - 01:00pm Eastern - September 30, 2020
Polly Chen, PhD, National University of Singapore, Singapore
Track: Dynamic Regulation of the Epitranscriptome

Wednesday
Career Roundtable
02:00pm - 03:00pm Eastern - September 30, 2020
Kate Meyer, PhD, Panelist, Duke University; Chuan He, PhD, Panelist, University of Chicago, USA; Lynn Abell, PhD, Panelist, Agios Pharmaceuticals
Track: Career Roundtable


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Kate Meyer, Duke University

Lynn Abell, Agios

Chuan He, University of Chicago


Event Date/Time: Wednesday, September 30, 2:00–3:00PM ET

As part of our commitment to support and train the next generation of scientific leaders from all backgrounds, Keystone Symposia hosts Career Roundtables at selected in-person and virtual conferences. These workshops create a forum for field leaders to provide their unique perspectives on career development, professional pitfalls and the breadth of scientific opportunities available to support trainee scientists. Established researchers are chosen from a broad range of backgrounds (i.e., diverse demographics, career stages and career paths) to reflect a myriad of career paths and experiences. A panel discussion is followed by break out group sessions to enable trainees to interact with each senior scientist in a comfortable small group setting, to address specific questions, allow for mentorship and networking.

For additional career advancement advice, see our Keypoint Blog "Words of Wisdom from Career Roundtables" with tips gleaned from past events on how to launch your career in academia, industry, publishing and beyond. Whether you are a student, post-doc, or early career investigator, check out these pearls of wisdom for all career stages!

https://keypoint.keystonesymposia.org/features/words-of-wisdom-from-career-roundtable-for-students-post-docs/


"Self" vs "Non-Self" RNA Pattern Recognition
03:00pm - 06:00pm Eastern - September 30, 2020
Carl Walkley, PhD, Co-Chair, St Vincent's Institute, Australia; Noam Stern-Ginossar, PhD, Co-Chair, Weizmann Institute of Science, Israel
Track: "Self" vs "Non-Self" RNA Pattern Recognition

Wednesday
RNA Methylation in Viral Infection
03:00pm - 03:30pm Eastern - September 30, 2020
Stacy M. Horner, PhD, Duke University Medical Center
Track: "Self" vs "Non-Self" RNA Pattern Recognition

Wednesday
The in vivo Functions of A-to-I Editing
03:30pm - 04:00pm Eastern - September 30, 2020
Carl Walkley, PhD, St Vincent's Institute, Australia
Track: "Self" vs "Non-Self" RNA Pattern Recognition

Wednesday
Short Talk: Cap-Proximal N6-Methylation Protects Viral mRNA against Interferon beta Pretreatment
04:00pm - 04:20pm Eastern - September 30, 2020
Michael Armen Tartell, BA, Harvard University
Track: "Self" vs "Non-Self" RNA Pattern Recognition

Wednesday
m6A and Innate Immunity
04:40pm - 05:10pm Eastern - September 30, 2020
Noam Stern-Ginossar, PhD, Weizmann Institute of Science, Israel
Track: "Self" vs "Non-Self" RNA Pattern Recognition

Wednesday
Circular RNA Immunity
05:10pm - 05:40pm Eastern - September 30, 2020
Grace Chen, PhD, Yale University School of Medicine
Track: "Self" vs "Non-Self" RNA Pattern Recognition

Wednesday
Short Talk: ADAR3 Alters the MAVS/NF-kappaB Signaling Pathway in Glioblastoma
05:40pm - 06:00pm Eastern - September 30, 2020
Reshma Kurup, MS, Indiana University, USA
Track: "Self" vs "Non-Self" RNA Pattern Recognition

Functions and Mechanism
10:00am - 01:00pm Eastern - October 1, 2020
Yunsun Nam, PhD, Co-Chair, University of Texas Southwestern Medical Center, USA; Peter Beal, PhD, Co-Chair, University of California, Davis, USA
Track: Functions and Mechanism

Thursday
ADAR RNA Editing and Genome Stability
10:30am - 11:00am Eastern - October 1, 2020
Kazuko Nishikura, PhD, Wistar Institute, USA
Track: Functions and Mechanism

Thursday
Uncovering m6A and Its Role in RNA Regulation
11:40am - 12:10pm Eastern - October 1, 2020
Kate Meyer, PhD, Duke University
Track: Functions and Mechanism

Thursday
Short Talk: CAPS1 RNA Editing Selectivity Mediates Dopamine Neurotransmission in the Dorsal Striatum
12:40pm - 01:00pm Eastern - October 1, 2020
Kayla Shumate, MS, Vanderbilt University, USA
Track: Functions and Mechanism

Understanding and Exploiting Epitranscriptome in Cancer
03:00pm - 06:00pm Eastern - October 1, 2020
Jianjun Chen, PhD, Co-Chair, Beckman Research Institute of City of Hope; F. Nina Papavasiliou, PhD, Co-Chair, Deutsches Krebsforschungszentrum, Germany
Track: Understanding and Exploiting Epitranscriptome in Cancer

Thursday
Human Recoding Sites: Profile, Evolution, Adaptation
03:00pm - 03:30pm Eastern - October 1, 2020
Eli Eisenberg, PhD, Tel Aviv University, Israel
Track: Understanding and Exploiting Epitranscriptome in Cancer

Thursday
m6A in Cancer
03:30pm - 04:00pm Eastern - October 1, 2020
Jianjun Chen, PhD, Beckman Research Institute of City of Hope
Track: Understanding and Exploiting Epitranscriptome in Cancer

Thursday
Short Talk: Dual Protection from Endogenous dsRNA-Induced Type-I IFN Responses by ADAR and hnRNPC
04:00pm - 04:20pm Eastern - October 1, 2020
Anna-Maria Herzner, PhD, Genentech, Inc., USA
Track: Understanding and Exploiting Epitranscriptome in Cancer

Thursday
RNA Deamination in Immunity and Cancer
04:40pm - 05:10pm Eastern - October 1, 2020
F. Nina Papavasiliou, PhD, Deutsches Krebsforschungszentrum, Germany
Track: Understanding and Exploiting Epitranscriptome in Cancer

Thursday
RNA Methylation and the Control of Cell Fate in the Blood
05:10pm - 05:40pm Eastern - October 1, 2020
Michael G. Kharas, PhD, Memorial Sloan Kettering Cancer Center
Track: Understanding and Exploiting Epitranscriptome in Cancer

Thursday
Short Talk: Loss of Adar1 in Pancreatic Acinar Cells Leads to Apoptosis and Inflammation
05:40pm - 06:00pm Eastern - October 1, 2020
Dhwani Rupani, MS, MD Anderson Cancer Center, USA
Track: Understanding and Exploiting Epitranscriptome in Cancer

Transcriptome Engineering and Technology Development
10:00am - 01:00pm Eastern - October 2, 2020
Eva Maria Novoa Pardo, PhD, Co-Chair, Centre for Genomic Regulation, Spain; Thorsten Stafforst, PhD, Co-Chair, Universität Tübingen, Germany
Track: Transcriptome Engineering and Technology Development

Friday
Harnessing ADAR Activity for Site-Directed RNA Editing
10:00am - 10:30am Eastern - October 2, 2020
Thorsten Stafforst, PhD, Universität Tübingen, Germany
Track: Transcriptome Engineering and Technology Development

Friday
Pseudouridine-Mediated Stop Codon Read Through
10:30am - 11:00am Eastern - October 2, 2020
Yi-Tao Yu, PhD, University of Rochester Medical Center, USA
Track: Transcriptome Engineering and Technology Development

Friday
Short Talk: Development of an Efficient and Specific Platform for Programmable RNA Base Editing
11:00am - 11:20am Eastern - October 2, 2020
Meng How Tan, PhD, Nanyang Technology University, Singapore
Track: Transcriptome Engineering and Technology Development

Friday
Quantitative Profiling of Pseudouridine Modification Dynamics Using Native RNA Nanopore Sequencing
11:40am - 12:10pm Eastern - October 2, 2020
Eva Maria Novoa Pardo, PhD, Centre for Genomic Regulation, Spain
Track: Transcriptome Engineering and Technology Development

Friday
Harnessing Novel CRISPR Systems for Programmable RNA Editing
12:10pm - 12:40pm Eastern - October 2, 2020
Omar Abudayyeh, PhD, Massachusetts Institute of Technology, USA; Jonathan Gootenberg, PhD, Massachusetts Institute of Technology, USA
Track: Transcriptome Engineering and Technology Development

Friday
Short Talk: Chemistry to Discover and Decode RNA Acetylation
12:40pm - 01:00pm Eastern - October 2, 2020
Supuni Thalalla Gamage, PhD, NCI, National Institutes of Health, USA
Track: Transcriptome Engineering and Technology Development

The Role of Epitranscriptome in Development and Stem Cell
03:00pm - 06:00pm Eastern - October 2, 2020
Kamil R. Kranc, MD, PhD, Co-Chair, Barts Cancer Institute, Queen Mary University of London, UK; Alexey Ruzov, PhD, Co-Chair, University of Nottingham, UK
Track: The Role of Epitranscriptome in Development and Stem Cell

Friday
m5C RNA Methylation
03:00pm - 03:30pm Eastern - October 2, 2020
Michaela Frye, PhD, Deutsches Krebsforschungszentrum, Germany
Track: The Role of Epitranscriptome in Development and Stem Cell

Friday
Short Talk: Acute Depletion of METTL3 Identifies a Role for N6-Methyladenosine in Alternative Intron/Exon Inclusion in the Nascent Transcriptome
03:30pm - 03:50pm Eastern - October 2, 2020
Guifeng Wei, PhD, University of Oxford, UK
Track: The Role of Epitranscriptome in Development and Stem Cell

Friday
Targeting m6A mRNA Readers in Blood Malignancies
03:50pm - 04:20pm Eastern - October 2, 2020
Kamil R. Kranc, MD, PhD, Barts Cancer Institute, Queen Mary University of London, UK
Track: The Role of Epitranscriptome in Development and Stem Cell

Friday
Short Talk: Dynamic Epitranscriptomic Regulation of Self-Renewing Epithelia via METTL3-Mediated m6A
04:25pm - 04:45pm Eastern - October 2, 2020
Brian C. Capell, MD, PhD, University of Pennsylvania, USA
Track: The Role of Epitranscriptome in Development and Stem Cell

Friday
The Role of m6A in R-Loop Regulation
04:45pm - 05:15pm Eastern - October 2, 2020
Alexey Ruzov, PhD, University of Nottingham, UK
Track: The Role of Epitranscriptome in Development and Stem Cell

Friday
Short Talk: ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress
05:15pm - 05:35pm Eastern - October 2, 2020
Diana Guallar, PhD, Universidade de Santiago de Compostela, Spain
Track: The Role of Epitranscriptome in Development and Stem Cell

Friday
Short Talk: Intersection between RNA Methylation and TDP43-Mediated Toxicity in ALS
05:35pm - 05:55pm Eastern - October 2, 2020
Michael McMillan, BS, University of Michigan, USA
Track: The Role of Epitranscriptome in Development and Stem Cell

Friday
Closing Remarks
05:55pm - 06:00pm Eastern - October 2, 2020
Michaela Frye, PhD, Chair, Deutsches Krebsforschungszentrum, Germany
Track: Closing Remarks