custom image

Genomic Stability and DNA Repair

September 21-23, 2020 | 10:00AM EDT | 2:00PM UTC*
*Program is in development and subject to change


Reset

Advanced Filters
Introductory Remarks and Keynote Address
10:00am - 10:30am Eastern - September 21, 2020
Track: Opening Remarks and Keynote Address

Monday
The Causes and Consequences of Replication Stress
10:00am - 10:30am Eastern - September 21, 2020
Karlene A. Cimprich, PhD, Stanford University
Track: Welcoming Remarks and Keynote Address

Replication and Cell Cycle Dependent Mechanisms of Genome Stability
10:30am - 01:00pm Eastern - September 21, 2020
Sharon Cantor, PhD, Co-Chair, University of Massachusetts Medical School; Karlene A. Cimprich, PhD, Co-Chair, Stanford University
Track: Replication and Cell Cycle Dependent Mechanisms of Genome Stability

Monday
Mechanisms, Regulation, and Consequences of Fork Remodeling
10:30am - 10:50am Eastern - September 21, 2020
David Cortez, PhD, Vanderbilt University School of Medicine
Track: Replication and Cell Cycle Dependent Mechanisms of Genome Stability

Monday
GLOE-Seq – A New Genomic Tool to Map Replication Patterns and DNA Lesions with Nucleotide Resolution
10:50am - 11:10am Eastern - September 21, 2020
Helle D. Ulrich, PhD, Institute of Molecular Biology
Track: Replication and Cell Cycle Dependent Mechanisms of Genome Stability

Monday
Mechanisms Driving the Rapid Evolution of Cancer Genomes
11:10am - 11:30am Eastern - September 21, 2020
David Pellman, MD, Dana-Farber Cancer Institute
Track: Replication and Cell Cycle Dependent Mechanisms of Genome Stability

Monday
Mechanisms that Maintain Genome Stability
11:50am - 12:10pm Eastern - September 21, 2020
André Nussenzweig, PhD, NCI, National Institutes of Health
Track: Replication and Cell Cycle Dependent Mechanisms of Genome Stability

Monday
Short Talk: Human DNA Replication Origins
12:10pm - 12:22pm Eastern - September 21, 2020
Marcel Mechali, Institute of Human Genetics, CNRS-University of Montpellier
Track: Replication and Cell Cycle Dependent Mechanisms of Genome Stability

Monday
Short Talk: Repair of G1 Induced DNA Double-Strand Breaks in S-G2/M Promotes Cell Survival at the Expense of Genome Integrity
12:22pm - 12:34pm Eastern - September 21, 2020
Ludovic Deriano, PhD, Institut Pasteur, Paris
Track: Replication and Cell Cycle Dependent Mechanisms of Genome Stability

Monday
Short Talk: Genome-Wide Mapping of Transcription-Replication Interactions in Mouse Primary B Cells
12:34pm - 12:46pm Eastern - September 21, 2020
Commodore Perry St. Germain, PhD, University of California, Davis
Track: Replication and Cell Cycle Dependent Mechanisms of Genome Stability

Monday
Short Talk: 3D Genome Organization Contributes to Genome Instability at Fragile Sites
12:46pm - 12:58pm Eastern - September 21, 2020
Dan Sarni, M.S., Hebrew University of Jerusalem
Track: Replication and Cell Cycle Dependent Mechanisms of Genome Stability

Monday
Career Roundtable
02:30pm - 03:30pm Eastern - September 21, 2020
Karlene A. Cimprich, PhD, Stanford University; Joel A. Klappenbach, PhD, Pfizer; Katharina Schlacher, PhD, MD Anderson Cancer Center
Track: Career Roundtable


Speaking at this Roundtable


“Yvonne “Priti “Evan


Karlene A. Cimprich, PhD, Stanford University

Joel A. Klappenbach, PhD, Pfizer

Katharina Schlacher, PhD, MD, Anderson Cancer Center


Event Date/Time: Monday, September 21, 2:30–3:30PM ET

As part of our commitment to support and train the next generation of scientific leaders from all backgrounds, Keystone Symposia hosts Career Roundtables at selected in-person and virtual conferences. These workshops create a forum for field leaders to provide their unique perspectives on career development, professional pitfalls and the breadth of scientific opportunities available to support trainee scientists. Established researchers are chosen from a broad range of backgrounds (i.e., diverse demographics, career stages and career paths) to reflect a myriad of career paths and experiences. A panel discussion is followed by break out group sessions to enable trainees to interact with each senior scientist in a comfortable small group setting, to address specific questions, allow for mentorship and networking.

For additional career advancement advice, see our Keypoint Blog "Words of Wisdom from Career Roundtables" with tips gleaned from past events on how to launch your career in academia, industry, publishing and beyond. Whether you are a student, post-doc, or early career investigator, check out these pearls of wisdom for all career stages!

https://keypoint.keystonesymposia.org/features/words-of-wisdom-from-career-roundtable-for-students-post-docs/



Mechanisms of Recombination and Repair
05:00pm - 08:00pm Eastern - September 21, 2020
Alberto Ciccia, PhD, Co-Chair, Columbia University; Anna Malkova, PhD, Co-Chair, University of Iowa
Track: Mechanisms of Recombination and Repair

Monday
Initiation of DNA End Resection by the Mre11 Complex
05:00pm - 05:20pm Eastern - September 21, 2020
Lorraine S. Symington, PhD, Columbia University
Track: Mechanisms of Recombination and Repair

Monday
BRCA Control of Homologous Recombination and Replication Fork Protection
05:20pm - 05:40pm Eastern - September 21, 2020
Maria Jasin, PhD, Memorial Sloan Kettering Cancer Center
Track: Mechanisms of Recombination and Repair

Monday
The Regulation of Homologous Recombination in G1-Phase Cells
05:40pm - 06:00pm Eastern - September 21, 2020
Barry P. Sleckman, MD, PhD, University of Alabama Birmingham School of Medicine
Track: Mechanisms of Recombination and Repair

Monday
Reconstitution of Homologous Recombination Pathways
06:00pm - 06:20pm Eastern - September 21, 2020
Patrick M. Sung, PhD, University of Texas Health Science Center at San Antonio
Track: Mechanisms of Recombination and Repair

Monday
Competition between DNA Repair Mechanisms
06:40pm - 07:00pm Eastern - September 21, 2020
Dipanjan Chowdhury, PhD, Dana-Farber Cancer Institute, Harvard Medical School
Track: Mechanisms of Recombination and Repair

Monday
Replication Origin Modulation: Preventing Runaway DNA Synthesis to Insure Genomic Stability
07:00pm - 07:20pm Eastern - September 21, 2020
Mirit Aladjem, PhD, NCI, National Institutes of Health
Track: Mechanisms of Recombination and Repair

Monday
Short Talk: Homologous Recombination Repair Domains: Function and Impact on Genome Stability
07:20pm - 07:32pm Eastern - September 21, 2020
Jennifer Zagelbaum, Columbia University
Track: Mechanisms of Recombination and Repair

Monday
Short Talk: The Role of Break-Induced Replication in Alternative Lengthening of Telomeres and in Formation of Complex Genomic Rearrangements
07:32pm - 07:44pm Eastern - September 21, 2020
Anna Malkova, PhD, University of Iowa
Track: Mechanisms of Recombination and Repair

Monday
Short Talk: Mutations and Structural Variants Arising During Double-Strand Break Repair
07:44pm - 07:56pm Eastern - September 21, 2020
James E. Haber, PhD, Brandeis University
Track: Mechanisms of Recombination and Repair

RNA Mechanisms of Genome Stability
10:00am - 12:00pm Eastern - September 22, 2020
Jo R. Morris, PhD, Co-Chair, University of Birmingham; Rémi Buisson, PhD, Co-Chair, University of California, Irvine
Track: RNA Mechanisms of Genome Stability

Tuesday
How the Long Noncoding RNA TERRA Associates with Telomeres via R-Loops
10:00am - 10:20am Eastern - September 22, 2020
Joachim Lingner, PhD, École Polytechnique Fédérale de Lausanne
Track: RNA Mechanisms of Genome Stability

Tuesday
Nuclear and Chromatin Dynamics for Heterochromatin Repair
10:20am - 10:40am Eastern - September 22, 2020
Irene Chiolo, PhD, University of Southern California
Track: RNA Mechanisms of Genome Stability

Tuesday
A Surprising Role of RNA Transcripts in Homologous Recombination
10:40am - 11:00am Eastern - September 22, 2020
Lee Zou, PhD, Harvard Medical School
Track: RNA Mechanisms of Genome Stability

Tuesday
Chromatin and Chromosome Dynamics at DNA Double Strand Breaks
11:00am - 11:20am Eastern - September 22, 2020
Gaelle Legube, PhD, Center for Integrative Biology
Track: RNA Mechanisms of Genome Stability

Tuesday
Short Talk: RASSF1A Tumor Suppressor Controls Ribosomal DNA Break Repair
11:20am - 11:32am Eastern - September 22, 2020
Dafni Eleftheria Pefani, University of Patras
Track: RNA Mechanisms of Genome Stability

Tuesday
Short Talk: Double Strand Break Relocation Correlates with Heterochromatic Repeat Clustering
11:32am - 11:44am Eastern - September 22, 2020
Ioanna Mitrentsi, MS, IGBMC Gie CERBM
Track: RNA Mechanisms of Genome Stability

Tuesday
Funding Panel Discussion
12:00pm - 01:00pm Eastern - September 22, 2020
Gaelle Legube, PhD, Co-Chair, Center for Integrative Biology; Dipanjan Chowdhury, PhD, Co-Chair, Dana-Farber Cancer Institute, Harvard Medical School; Keren Witkin, PhD, NCI, National Institutes of Health; Philipp Oberdoerffer, PhD, NCI, National Institutes of Health; Geneviève Almouzni, PhD, Centre National de la Recherche Scientifique; Gerlind Wallon
Track: Funding Panel Discussion

DNA Repair Mechanisms in Cancer
05:00pm - 08:00pm Eastern - September 22, 2020
Ralph Scully, MD, PhD, Co-Chair, Beth Israel Deaconess Medical Center; Gaorav Gupta, MD, PhD, Co-Chair, University of North Carolina, Chapel Hill
Track: DNA Repair Mechanisms in Cancer

Tuesday
Molecular Interplay between BRCA1-BARD1 Complexes and the 53BP1 Pathway
05:00pm - 05:20pm Eastern - September 22, 2020
J. Ross Chapman, PhD, University of Oxford
Track: DNA Repair Mechanisms in Cancer

Tuesday
Navigating the Genetic Networks Underpinning Genome Integrity
05:20pm - 05:40pm Eastern - September 22, 2020
Daniel Durocher, PhD, Lunenfeld-Tanenbaum Research Institute
Track: DNA Repair Mechanisms in Cancer

Tuesday
New Players in the Alkylation Damage Response
05:40pm - 06:00pm Eastern - September 22, 2020
Nima Mosammaparast, MD, PhD, Washington University in St. Louis
Track: DNA Repair Mechanisms in Cancer

Tuesday
Chromatin Accessibility - A New Vulnerability in BRCA Mutant Cancers
06:00pm - 06:20pm Eastern - September 22, 2020
Roger Greenberg, MD, PhD, University of Pennsylvania
Track: DNA Repair Mechanisms in Cancer

Tuesday
Short Talk: Structure and Function of the WRN Helicase ATPase Domain as a Dependency in MSI-H Cancer Cells
06:40pm - 06:52pm Eastern - September 22, 2020
Madhwesh Coimbatore Ravichandran, Boehringer Ingelheim RCV GmbH & Co KG
Track: DNA Repair Mechanisms in Cancer

Tuesday
Short Talk: Defining the Role of Translesion Synthesis in BRCA1/2-Mutant Cancer Cells
06:52pm - 07:04pm Eastern - September 22, 2020
Alberto Ciccia, PhD, Columbia University
Track: DNA Repair Mechanisms in Cancer

Tuesday
Short Talk: An in vivo Genetic Screen for Tumor Suppressive DNA Damage Responses in Myc-Induced Breast Cancer
07:04pm - 07:16pm Eastern - September 22, 2020
Gaorav Gupta, MD, PhD, University of North Carolina, Chapel Hill
Track: DNA Repair Mechanisms in Cancer

Tuesday
Short Talk: Repression of HR ‘Back-Up’ Pathway Use by BRCA1
07:16pm - 07:28pm Eastern - September 22, 2020
Jo R. Morris, PhD, University of Birmingham
Track: DNA Repair Mechanisms in Cancer

Tuesday
Short Talk: The Use of Microhomologies by RAD51 Promotes Genomic Rearrangements between Non Homologous Sequences
07:28pm - 07:40pm Eastern - September 22, 2020
Track: DNA Repair Mechanisms in Cancer

Tuesday
Short Talk: Mechanisms of Mutagenesis Induced by APOBEC3A in Tumors: The Genomic “Twin Paradox”
07:40pm - 07:52pm Eastern - September 22, 2020
Rémi Buisson, PhD, University of California, Irvine
Track: DNA Repair Mechanisms in Cancer

Tuesday
Short Talk: Persistent Broken Chromosome Inheritance Drives Genome Instability
07:52pm - 08:04pm Eastern - September 22, 2020
Timothy C. Humphrey, PhD, University of Oxford
Track: DNA Repair Mechanisms in Cancer

Day 3 Keynote Address
10:00am - 10:30am Eastern - September 23, 2020
Dipanjan Chowdhury, PhD, Chair, Dana-Farber Cancer Institute, Harvard Medical School
Track: Opening Remarks and Keynote Address

Wednesday
The Deshieldin Complex Regulates DNA Repair Pathway Choice
10:00am - 10:30am Eastern - September 23, 2020
Alan D. D'Andrea, MD, Dana-Farber Cancer Institute
Track: Keynote Address

Genome Stability, Human Physiology and Therapeutic Potential
10:30am - 01:00pm Eastern - September 23, 2020
Petr Cejka, PhD, Co-Chair, Institute for Research in Biomedicine; Anna Malkova, PhD, Co-Chair, University of Iowa
Track: Genome Stability, Human Physiology and Therapeutic Potential

Wednesday
TRF2-Independent Chromosome End Protection in Pluripotent Cells and Early Development
10:30am - 10:50am Eastern - September 23, 2020
Simon J. Boulton, PhD, Francis Crick Institute
Track: Genome Stability, Human Physiology and Therapeutic Potential

Wednesday
Mechanisms of Telomere End Protection
10:50am - 11:10am Eastern - September 23, 2020
Jacqueline J. Jacobs, PhD, Netherlands Cancer Institute
Track: Genome Stability, Human Physiology and Therapeutic Potential

Wednesday
Targeting BRCA beyond PARP Inhibitors
11:10am - 11:30am Eastern - September 23, 2020
Madalena Tarsounas, PhD, University of Oxford
Track: Genome Stability, Human Physiology and Therapeutic Potential

Wednesday
The Role of CST/Polalpha/Primase in DSB Repair
11:50am - 12:10pm Eastern - September 23, 2020
Titia de Lange, PhD, Rockefeller University
Track: Genome Stability, Human Physiology and Therapeutic Potential

Wednesday
Short Talk: Cas9-Induced Large Deletions and Small Indels are Controlled in a Convergent Fashion
12:10pm - 12:22pm Eastern - September 23, 2020
Michael Kosicki, PhD, Lawrence Berkeley National Laboratory
Track: Genome Stability, Human Physiology and Therapeutic Potential

Wednesday
Short Talk: New Insight into the Relationship between UV Damage Formation, Transcription and Mutagenesis
12:22pm - 12:34pm Eastern - September 23, 2020
Sheera Adar, PhD, Hebrew Institute of Jerusalem
Track: Genome Stability, Human Physiology and Therapeutic Potential

Wednesday
Short Talk: Mono-ubiquitination by the FA Core Complex Clamps FANCI:FANCD2 on DNA as a Filamentous Array
12:34pm - 12:46pm Eastern - September 23, 2020
Winnie Tan, PhD, St Vincent's Institute
Track: Genome Stability, Human Physiology and Therapeutic Potential

Wednesday
Short Talk: ELOF1 is a Transcription-Coupled DNA Repair Factor that Directs RNA Polymerase II Ubiquitylation
12:46pm - 12:58pm Eastern - September 23, 2020
Yana van der Weegen, MSc, Leiden University Medical Center
Track: Genome Stability, Human Physiology and Therapeutic Potential

Emerging Concepts in Genome Stability
05:00pm - 08:00pm Eastern - September 23, 2020
Gaelle Legube, PhD, Center for Integrative Biology; Sheera Adar, PhD, Hebrew Institute of Jerusalem
Track: Emerging Concepts in Genome Stability

Wednesday
Polygenic Mutations Model the Pleiotropic Disease of Fanconi Anemia
05:00pm - 05:20pm Eastern - September 23, 2020
Katharina Schlacher, PhD, MD Anderson Cancer Center
Track: Emerging Concepts in Genome Stability

Wednesday
Strange Tales of Genomic Instability: eccDNAs and Life without ORC
05:20pm - 05:40pm Eastern - September 23, 2020
Anindya Dutta, PhD, University of Virginia
Track: Emerging Concepts in Genome Stability

Wednesday
Short Talk: TopBP1 Assembles Nuclear Condensates to Switch on ATR Signalling
05:40pm - 05:52pm Eastern - September 23, 2020
Track: Emerging Concepts in Genome Stability

Wednesday
Short Talk: Mitochondria Responds to DNA Damage with Adjusted Mitophagy
05:52pm - 06:04pm Eastern - September 23, 2020
Xiuli Dan, PhD, National Institutes of Health
Track: Emerging Concepts in Genome Stability

Wednesday
Short Talk: High-Throughput Single Cell Sequencing for Studying HR Partner Choice
06:04pm - 06:16pm Eastern - September 23, 2020
Yi Yin, PhD, University of California, Los Angeles
Track: Emerging Concepts in Genome Stability

Wednesday
Industry Panel Discussion
06:35pm - 07:45pm Eastern - September 23, 2020
Roger Greenberg, MD, PhD, Co-Chair, University of Pennsylvania; Alan D. D'Andrea, MD, Co-Chair, Dana-Farber Cancer Institute; Katya Marjon, PhD, Agios Pharmaceuticals; Josep V Forment, PhD, AstraZeneca; Scott Pesiridis, PhD, GlaxoSmithKline; Robert T. Abraham, PhD, Vividion Therapeutics; Cory Johannessen, Novartis
Track: Industry Panel Discussion

Wednesday
Closing Remarks (Organizers)
07:45pm - 08:00pm Eastern - September 23, 2020
Track: Closing Remarks (Organizers)