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Myeloid Cells and Innate Immunity in Solid Tumors

September 21-23, 2020 | 10:00AM EDT | 2:00PM UTC*
*Program is in development and subject to change

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Introductory Remarks and Keynote Address
10:00am - 10:30am Eastern - September 21, 2020
Judith A. Varner, PhD, Chair, University of California, San Diego
Track: Opening Remarks and Keynote Address

Monday
CD40 as a Gateway Pathway in the Tumor Microenvironment
10:00am - 10:30am Eastern - September 21, 2020
Robert H. Vonderheide, MD, PhD, University of Pennsylvania
Track: Keynote Address

Ontogeny of Myeloid Cells in Cancer
10:30am - 01:00pm Eastern - September 21, 2020
Judith A. Varner, PhD, Co-Chair, University of California, San Diego; Dmitry I. Gabrilovich, MD, PhD, Co-Chair, AstraZeneca
Track: Ontogeny of Myeloid Cells in Cancer

Monday
Identification of a Dendritic Cells Immunoregulatory Program that Dampens Tumor Specific Immunity
10:30am - 10:55am Eastern - September 21, 2020
Miriam Merad, MD, PhD, Mount Sinai School of Medicine
Track: Ontogeny of Myeloid Cells in Cancer

Monday
Mechanisms Governing Accumulation of Macrophages in Cancer
10:55am - 11:20am Eastern - September 21, 2020
Track: Ontogeny of Myeloid Cells in Cancer

Monday
Origins of Macrophages in Pancreatic Cancer
11:40am - 12:05pm Eastern - September 21, 2020
David G. DeNardo, PhD, Washington University Medical School
Track: Ontogeny of Myeloid Cells in Cancer

Monday
Monocyte-Like Precursors of Granulocytes in Cancer
12:05pm - 12:30pm Eastern - September 21, 2020
Track: Ontogeny of Myeloid Cells in Cancer

Monday
Short Talk: Dissecting the Role of MerTK Signaling in Promoting Alternatively Activated Macrophages Polarization
12:30pm - 12:45pm Eastern - September 21, 2020
Chang Su, Duke University
Track: Ontogeny of Myeloid Cells in Cancer

Monday
Short Talk: Single Cell Sequencing Identifies Novel Metastasis-Associated Macrophage Subsets in the Lung
12:45pm - 01:00pm Eastern - September 21, 2020
Danielle N. Huggins, PhD, University of Minnesota
Track: Ontogeny of Myeloid Cells in Cancer

Epigenetics, Metabolism and Metastasis of Myeloid Cells in Cancer
05:00pm - 08:00pm Eastern - September 21, 2020
Catherine Hedrick, PhD, Co-Chair, La Jolla Institute for Immunology; Weiping Zou, MD, PhD, Co-Chair, University of Michigan
Track: Epigenetics, Metabolism and Metastasis of Myeloid Cells in Cancer

Monday
Serous Cavity Macrophages and Ovarian Cancer in the Peritoneum-Studies in Mice
05:00pm - 05:25pm Eastern - September 21, 2020
Gwendalyn J. Randolph, PhD, Washington University
Track: Epigenetics, Metabolism and Metastasis of Myeloid Cells in Cancer

Monday
Myeloid Cells in Modulating Cancer Metastasis
05:25pm - 05:50pm Eastern - September 21, 2020
Catherine Hedrick, PhD, La Jolla Institute for Immunology
Track: Epigenetics, Metabolism and Metastasis of Myeloid Cells in Cancer

Monday
Impact of Autophagy on Tumor-Associated Macrophages and Cancer Metastasis
05:50pm - 06:15pm Eastern - September 21, 2020
Weiping Zou, MD, PhD, University of Michigan
Track: Epigenetics, Metabolism and Metastasis of Myeloid Cells in Cancer

Monday
Epigenetic Control of Myeloid Cells in Cancer
06:40pm - 07:05pm Eastern - September 21, 2020
Diana Hargreaves, PhD, The Salk Institute for Biological Studies
Track: Epigenetics, Metabolism and Metastasis of Myeloid Cells in Cancer

Monday
Macrophage and Dendritic Cell Biology: From Development to Functions
07:05pm - 07:30pm Eastern - September 21, 2020
Florent Ginhoux, PhD, Singapore Immunology Network
Track: Epigenetics, Metabolism and Metastasis of Myeloid Cells in Cancer

Monday
Short Talk: Tumor-Immune Communication via Extracellular Vesicles: A Lymph Node Macrophage Link
07:30pm - 07:45pm Eastern - September 21, 2020
Ferdinando Pucci, PhD, Oregon Health & Science University
Track: Epigenetics, Metabolism and Metastasis of Myeloid Cells in Cancer

Monday
Short Talk: Eosinophils Inhibit Pulmonary Metastasis and Directly Kill Tumor Cells
07:45pm - 08:00pm Eastern - September 21, 2020
Rachel Cederberg, BS, BC Cancer Research Centre
Track: Epigenetics, Metabolism and Metastasis of Myeloid Cells in Cancer

Immune Suppression and Metastasis Mediated by Myeloid Cells
10:00am - 01:00pm Eastern - September 22, 2020
Jeffrey W. Pollard, PhD, Co-Chair, Queen's Medical Research Institute; Vincenzo Bronte, MD, Co-Chair, University of Verona
Track: Immune Suppression and Metastasis Mediated by Myeloid Cells

Tuesday
Re-tuning the Tumor Microenvironment to Promote Immunotherapy
10:00am - 10:25am Eastern - September 22, 2020
Jeffrey W. Pollard, PhD, Queen's Medical Research Institute
Track: Immune Suppression and Metastasis Mediated by Myeloid Cells

Tuesday
Transcriptional Profiling of Glioblastoma-Associated Myeloid Cells across Species and Disease Stage Reveals Macrophage Competition and Functional Specialization
10:25am - 10:50am Eastern - September 22, 2020
Jo A. Van Ginderachter, PhD, VIB-Vrije Universiteit Brussel
Track: Immune Suppression and Metastasis Mediated by Myeloid Cells

Tuesday
DAB2-Expressing TAMs Promote Cancer Cell Invasion
10:50am - 11:15am Eastern - September 22, 2020
Vincenzo Bronte, MD, University of Verona
Track: Immune Suppression and Metastasis Mediated by Myeloid Cells

Tuesday
Metabolic Regulation of Myeloid Derived Suppressor Cells in Cancer
11:40am - 12:05pm Eastern - September 22, 2020
Antonio Sica, PhD, University of Eastern Piedmont
Track: Immune Suppression and Metastasis Mediated by Myeloid Cells

Tuesday
Myeloid Cells in Pancreatic Cancer Metastasis
12:05pm - 12:30pm Eastern - September 22, 2020
Michael C. Schmid, PhD, University of Liverpool
Track: Immune Suppression and Metastasis Mediated by Myeloid Cells

Tuesday
Short Talk: Wobble tRNA Modification and Translation Reprogramming in the Tumour Microenvironment during Breast Cancer Development
12:30pm - 12:45pm Eastern - September 22, 2020
Pierre Close, PhD, University of Liege
Track: Immune Suppression and Metastasis Mediated by Myeloid Cells

Tuesday
Short Talk: Amyloid β Secreted by the Tumor Microenvironment Drives Neutrophil Extracellular Traps Production to Support Tumor Progression
12:45pm - 01:00pm Eastern - September 22, 2020
Hafsa Munir, PhD, University of Cambridge
Track: Immune Suppression and Metastasis Mediated by Myeloid Cells

Tuesday
Career Roundtable
02:30pm - 03:30pm Eastern - September 22, 2020
Simon T. Barry, PhD, AstraZeneca; Claudia Jakubzick, PhD, Dartmouth College; Rosandra Natasha Kaplan, MD, NCI, National Institutes of Health
Track: Career Roundtable


Speaking at this Roundtable


“Yvonne “Priti “Evan


Simon T. Barry, PhD, AstraZeneca

Claudia Jakubzick, PhD, Dartmouth College

Rosandra N. Kaplan, MD, NCI, National Institutes of Health



Event Date/Time: Tuesday, September 22, 2:30–3:30PM ET

As part of our commitment to support and train the next generation of scientific leaders from all backgrounds, Keystone Symposia hosts Career Roundtables at selected in-person and virtual conferences. These workshops create a forum for field leaders to provide their unique perspectives on career development, professional pitfalls and the breadth of scientific opportunities available to support trainee scientists. Established researchers are chosen from a broad range of backgrounds (i.e., diverse demographics, career stages and career paths) to reflect a myriad of career paths and experiences. A panel discussion is followed by break out group sessions to enable trainees to interact with each senior scientist in a comfortable small group setting, to address specific questions, allow for mentorship and networking.

For additional career advancement advice, see our Keypoint Blog "Words of Wisdom from Career Roundtables" with tips gleaned from past events on how to launch your career in academia, industry, publishing and beyond. Whether you are a student, post-doc, or early career investigator, check out these pearls of wisdom for all career stages!

https://keypoint.keystonesymposia.org/features/words-of-wisdom-from-career-roundtable-for-students-post-docs/


Promotion of Tumor Progression by Myeloid Cells
05:00pm - 08:00pm Eastern - September 22, 2020
Mikala Egeblad, PhD, Co-Chair, Cold Spring Harbor Laboratory; Rosandra Natasha Kaplan, MD, Co-Chair, NCI, National Institutes of Health
Track: Promotion of Tumor Progression by Myeloid Cells

Tuesday
Activating a Collaborative Innate-Adaptive Immune Response to Control Metastasis
05:00pm - 05:25pm Eastern - September 22, 2020
Mikala Egeblad, PhD, Cold Spring Harbor Laboratory
Track: Promotion of Tumor Progression by Myeloid Cells

Tuesday
Horizontal Transfer of Macrophage Mitochondria in Cancer
05:25pm - 05:50pm Eastern - September 22, 2020
Minna Roh-Johnson, PhD, University of Utah
Track: Promotion of Tumor Progression by Myeloid Cells

Tuesday
Rediscovering the Role of B Cells in Cancer Immune Surveillance
05:50pm - 06:15pm Eastern - September 22, 2020
Claudia Jakubzick, PhD, Dartmouth College
Track: Promotion of Tumor Progression by Myeloid Cells

Tuesday
Eavesdropping on the Conversation between Immune and Epithelial Stem Cells during Tissue Repair
06:40pm - 07:05pm Eastern - September 22, 2020
Shruti Naik, PhD, New York University
Track: Promotion of Tumor Progression by Myeloid Cells

Tuesday
Myeloid Cells as Regulators of Immune Suppression in the Pre-Metastatic Niche and Myeloid Based Approaches to Rebalance the Dysregulated Niche
07:05pm - 07:30pm Eastern - September 22, 2020
Rosandra Natasha Kaplan, MD, NCI, National Institutes of Health
Track: Promotion of Tumor Progression by Myeloid Cells

Tuesday
Short Talk: Blocking Dying Tumor Cell Clearance Enhances Antitumor Immune Response
07:30pm - 07:45pm Eastern - September 22, 2020
Mingjian Fei, Genentech
Track: Promotion of Tumor Progression by Myeloid Cells

Tuesday
Short Talk: Lipid Metabolism Controls Macrophage Functional Reprogramming in Tumor Microenvironment
07:45pm - 08:00pm Eastern - September 22, 2020
Ziyan Zoe Xu, BS, The Salk Institute
Track: Promotion of Tumor Progression by Myeloid Cells

Targeting Myeloid Cells in Cancer Therapy I
10:00am - 01:00pm Eastern - September 23, 2020
Lisa M. Coussens, PhD, Co-Chair, Oregon Health & Science University; Simon T. Barry, PhD, Co-Chair, AstraZeneca
Track: Targeting Myeloid Cells in Cancer Therapy I

Wednesday
Therapeutic Targeting of Macrophages: Lessons Learned from Mouse Models and Their Translation to the Clinic
10:00am - 10:25am Eastern - September 23, 2020
Lisa M. Coussens, PhD, Oregon Health & Science University
Track: Targeting Myeloid Cells in Cancer Therapy I

Wednesday
CD47 Targeting in Cancer Therapy
10:25am - 10:50am Eastern - September 23, 2020
Limin Shang, PhD, Light Chain Bioscience
Track: Targeting Myeloid Cells in Cancer Therapy I

Wednesday
Therapeutic Targeting of Macrophages and Neutrophils
10:50am - 11:15am Eastern - September 23, 2020
Simon T. Barry, PhD, AstraZeneca
Track: Targeting Myeloid Cells in Cancer Therapy I

Wednesday
MTL - CEBPA - Next Generation Immunotherapy Targeting Myeloid Cell Differentiation
11:40am - 12:05pm Eastern - September 23, 2020
Nagy A. Habib, MD, PhD, Imperial College London and MiNA Therapeutics
Track: Targeting Myeloid Cells in Cancer Therapy I

Wednesday
Short Talk: Unravelling the Identity and Function of MDSC in Human Cancer Patients
12:05pm - 12:20pm Eastern - September 23, 2020
Sven Brandau, PhD, University Hospital Essen
Track: Targeting Myeloid Cells in Cancer Therapy I

Wednesday

Wednesday
Short Talk: Polarization of TAMs by Iron Nanoparticles as an Adjuvant Lung Cancer Therapy
12:35pm - 12:50pm Eastern - September 23, 2020
Natalie Horvat, MSc, European Molecular Biological Laboratories
Track: Targeting Myeloid Cells in Cancer Therapy I

Targeting Myeloid Cells in Cancer Therapy II
05:00pm - 08:00pm Eastern - September 23, 2020
Jennifer Guerriero, PhD, Co-Chair, Dana-Farber Cancer Institute; David A. Cheresh, PhD, Co-Chair, University of California, San Diego
Track: Targeting Myeloid Cells in Cancer Therapy II

Wednesday
Targeting PI3K-gamma with IPI-549, a Tumor Macrophage-Reprogramming Small Molecule, in Patients with Advanced Solid Tumors
05:00pm - 05:25pm Eastern - September 23, 2020
Brenda C. O'Connell, PhD, Infinity Pharmaceuticals, Inc
Track: Targeting Myeloid Cells in Cancer Therapy II

Wednesday

Wednesday
Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression
05:50pm - 06:15pm Eastern - September 23, 2020
David A. Cheresh, PhD, University of California, San Diego
Track: Targeting Myeloid Cells in Cancer Therapy II

Wednesday
Short Talk: Antagonistic Antibodies Targeting LAIR1 Promote Inflammatory Phenotypes in Myeloid Cells and Activate Lymphocytes
06:40pm - 06:55pm Eastern - September 23, 2020
Caroline Bonnans, Immune-Onc Therapeutics
Track: Targeting Myeloid Cells in Cancer Therapy II

Wednesday
Short Talk: PKC Delta Activation Restricts Innate Immune Suppression and Promotes antigen Presentation in Triple Negative Breast Cancer
07:10pm - 07:25pm Eastern - September 23, 2020
Mehdi Chaib, M.S., University of Tennessee Health Science Center
Track: Targeting Myeloid Cells in Cancer Therapy II

Wednesday
Short Talk: Extracellular Vesicles Derived from a Commensal Bacteria Enhance Anticancer Immunity by Modulating Tumor Infiltrating Immune Cells
07:25pm - 07:40pm Eastern - September 23, 2020
Jihong Bae, M.S., Korea Advanced Institute of Science and Technology
Track: Targeting Myeloid Cells in Cancer Therapy II

Wednesday
Closing Remarks (Organizers)
07:45pm - 08:00pm Eastern - September 23, 2020