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Advances in Cancer Immunotherapy

August 17–19, 2020 | 10:00AM EDT | 2:00PM UTC | 4:00PM CEST*
*Program is subject to change


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Introductory Remarks and Keynote Address
10:00am - 10:40am Eastern - August 17, 2020
James P. Allison, PhD, University of Texas MD Anderson Cancer Center; Priti Hegde, PhD, Foundation Medicine; Antoni Ribas, MD, PhD, University of California, Los Angeles

Monday
Organizer Introductory Remarks
10:00am - 10:10am Eastern - August 17, 2020
Priti Hegde, PhD, Foundation Medicine; Antoni Ribas, MD, PhD, University of California, Los Angeles
Track: Introductory Remarks and Keynote Address

Monday
Immune Checkpoint Blockade in Cancer Therapy: New Insights into Therapeutic Mechanisms
10:10am - 10:40am Eastern - August 17, 2020
James P. Allison, PhD, University of Texas MD Anderson Cancer Center
Track: Keynote Address

[Full Session] Mechanisms of Action I
10:40am - 11:35am Eastern - August 17, 2020
Kelli Connolly, PhD, Co-Chair, Yale University; Ira Mellman, PhD, Co-Chair, Genentech, Inc.
Track: Mechanisms of Action I

Monday
Mechanistic Basis of Cancer Immunotherapy
10:40am - 11:05am Eastern - August 17, 2020
Ira Mellman, PhD, Genentech, Inc.
Track: Mechanisms of Action I

Monday
Short Talk: Tumor-Draining Lymph Nodes Contain an Untapped Reservoir of Stem-Like CD8 T Cells
11:05am - 11:20am Eastern - August 17, 2020
Kelli Connolly, PhD, Yale University
Track: Mechanisms of Action I

Monday
Short Talk: Loss of EMC Inhibits Tumor Growth through Enhanced Adaptive Immune Response
11:20am - 11:35am Eastern - August 17, 2020
AHyun Choi, PhD, Novartis Institutes for BioMedical Research
Track: Mechanisms of Action I

[Full Session] Mechanisms of Action II
12:00pm - 01:05pm Eastern - August 17, 2020
Kelli Connolly, PhD, Co-Chair, Yale University; Ira Mellman, PhD, Co-Chair, Genentech, Inc.
Track: Mechanisms of Action II

Monday
Identifying New Targets for Cancer Immunotherapy
12:00pm - 12:20pm Eastern - August 17, 2020
Jane Oliaro, PhD, Peter MacCallum Cancer Centre
Track: Mechanisms of Action II

Monday
Short Talk: PD-1 Signals Are Critical for Maintenance of CD8 T Cell Memory
12:20pm - 12:35pm Eastern - August 17, 2020
Vandana Kalia, PhD, University of Washington & Seattle Children’s Research Institute
Track: Mechanisms of Action II

Monday
Short Talk: Integrating DNA and RNA Sequencing Analysis to Describe Somatic Alterations and Expression in the HLA Gene Loci
12:35pm - 12:50pm Eastern - August 17, 2020
Katie Campbell, PhD, University of California, Los Angeles
Track: Mechanisms of Action II

Monday
Short Talk: Late Interferon-Gamma Blockade Improves Antitumor Efficacy of Anti-CTLA-4 and Anti-PD-1 Combination Treatment
12:50pm - 01:05pm Eastern - August 17, 2020
Stephen Mok, MD Anderson Cancer Center
Track: Mechanisms of Action II

Monday
Keystone Symposia Career Roundtable
02:00pm - 03:00pm Eastern - August 17, 2020


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Yvonne Y. Chen, PhD, University of California, Los Angeles

Priti Hegde, PhD, Foundation Medicine

Evan Scott, PhD, Northwestern University


Event Date/Time: Monday, August 17, 2:00–3:00PM ET

As part of our commitment to support and train the next generation of scientific leaders from all backgrounds, Keystone Symposia hosts Career Roundtables at selected in-person and virtual conferences. These workshops create a forum for field leaders to provide their unique perspectives on career development, professional pitfalls and the breadth of scientific opportunities available to support trainee scientists. Established researchers are chosen from a broad range of backgrounds (i.e., diverse demographics, career stages and career paths) to reflect a myriad of career paths and experiences. A panel discussion is followed by break out group sessions to enable trainees to interact with each senior scientist in a comfortable small group setting, to address specific questions, allow for mentorship and networking.


[Full Session] Mechanisms of Response I
05:00pm - 06:25pm Eastern - August 17, 2020
Siwen Hu-Lieskovan, MD, PhD, Co-Chair, Huntsman Cancer Institute; Yuxuan Miao, PhD, Co-Chair, Rockefeller University
Track: Mechanisms of Response I

Monday
Clinical Testing Strategies against Heterogenous Mechanisms of Immune Resistance
05:05pm - 05:35pm Eastern - August 17, 2020
Siwen Hu-Lieskovan, MD, PhD, Huntsman Cancer Institute
Track: Mechanisms of Response I

Monday
Mechanisms of Primary and Acquired Resistance to PD-1 Blockade Therapy
05:35pm - 06:05pm Eastern - August 17, 2020
Antoni Ribas, MD, PhD, University of California, Los Angeles
Track: Mechanisms of Response I

Monday
Short Talk: Neuropilin-1 Is a T Cell Memory Checkpoint Limiting Long-Term Anti-Tumor Immunity
06:05pm - 06:25pm Eastern - August 17, 2020
Chang Liu, PhD, University of Pittsburgh
Track: Mechanisms of Response I

[Full Session] Mechanisms of Response II
06:50pm - 08:00pm Eastern - August 17, 2020
Siwen Hu-Lieskovan, MD, PhD, Co-Chair, Huntsman Cancer Institute; Yuxuan Miao, PhD, Co-Chair, Rockefeller University
Track: Mechanisms of Response II

Monday
From the Clinic to the Lab: Investigating Mechanisms of Response and Resistance to Immune Checkpoint Therapy
06:50pm - 07:15pm Eastern - August 17, 2020
Padmanee Sharma, MD, PhD, University of Texas MD Anderson Cancer Center
Track: Mechanisms of Response II

Monday
Short Talk: Adaptive Immune Resistance Emerges From Tumor-Initiating Stem Cells
07:15pm - 07:30pm Eastern - August 17, 2020
Yuxuan Miao, PhD, Rockefeller University
Track: Mechanisms of Response II

Monday
Short Talk: Characterization of Myeloid Cells Subsets in the Tumor Microenvironment of Merkel Cell Carcinoma
07:30pm - 07:45pm Eastern - August 17, 2020
Shira Tabachnick-Cherny, PhD, University of Washington
Track: Mechanisms of Response II

Monday

[Full Session] Therapeutic Play I
10:00am - 11:40am Eastern - August 18, 2020
Juan C. Jaen, PhD, Co-Chair, Arcus Biosciences, Inc.; Evan Scott, PhD, Co-Chair, Northwestern University
Track: Therapeutic Play I

Tuesday
Engineering Next-Generation CAR-T Cell Therapy for Cancer
10:05am - 10:30am Eastern - August 18, 2020
Yvonne Y. Chen, PhD, University of California, Los Angeles
Track: Therapeutic Play I

Tuesday
Clinical Applications of Adenosine Pathway Inhibitors
10:30am - 10:55am Eastern - August 18, 2020
Juan C. Jaen, PhD, Arcus Biosciences, Inc.
Track: Therapeutic Play I

Tuesday
Short Talk: Cell Penetrating Peptides Improve T Cell Response to Neoantigen Peptide Vaccines
10:55am - 11:10am Eastern - August 18, 2020
Coralie Backlund, PhD, Massachusetts Institute of Technology
Track: Therapeutic Play I

Tuesday
Short Talk: Engineering Remotely Controllable CAR T Cells for Cancer Immunotherapy
11:25am - 11:40am Eastern - August 18, 2020
Yingxiao Wang, PhD, University of California, San Diego
Track: Therapeutic Play I

[Full Session] Therapeutic Play II
11:40am - 01:15pm Eastern - August 18, 2020
Juan C. Jaen, PhD, Co-Chair, Arcus Biosciences, Inc.; Evan Scott, PhD, Co-Chair, Northwestern University
Track: Therapeutic Play II

Tuesday
Engineered Nanobiomaterials for Cancer Immunotherapy
11:40am - 12:05pm Eastern - August 18, 2020
Evan Scott, PhD, Northwestern University
Track: Therapeutic Play II

Tuesday
Epigenetic Features of Exhausted Antitumor T Cells
12:05pm - 12:30pm Eastern - August 18, 2020
E. John Wherry, PhD, University of Pennsylvania
Track: Therapeutic Play II

Tuesday
Short Talk: Targeting the Stress Response Kinase GCN2 Potentiates Anti-Tumor Immune Response
12:30pm - 12:45pm Eastern - August 18, 2020
Buvana Ravishankar, PhD, Rapt Therapeutics, Inc.
Track: Therapeutic Play II

Tuesday

Tuesday
Short Talk: Personal Neoantigen Vaccines Induce Long-term Immune Responses in Patients with High Risk Melanoma
01:00pm - 01:15pm Eastern - August 18, 2020
Patrick A. Ott, MD, PhD, Dana-Farber Cancer Institute
Track: Therapeutic Play II

Tuesday
Meet-the-Editors Roundtable
02:00pm - 03:00pm Eastern - August 18, 2020


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Paloma Portela Torres, MPhil, SAGE Publishing

Lise Roth, PhD, EMBO Molecular Medicine

Alessandra Fornarelli, Dr. rer. nat., Frontiers in Immunology


Join Roundtable


Event Date/Time: Tuesday, August 18, 2:00–3:00PM ET

In this Meet-the-Editors ePanel, representatives from top tier journals including EMBO, Frontiers and SAGE Publishing, will discuss the state and direction of the field from the publishing perspective. In addition, they will share key tips on how to publish your work, and what they are looking for at the meeting.

Meet-the-Editor panels are important aspects of both in-person and virtual Keystone Symposia meetings, designed to foster connections between editors and scientists. These mutually beneficial relationships help to facilitate the publication process for researchers, while providing editors insight into exciting new discoveries and research directions to showcase in upcoming journal issues. We encourage you to take advantage of this special session, and to reach out to these editors during the meeting, to get the inside scoop on fast-tracking your work for publication.

Join us for this 30-minute ePanel discussion followed by a 30-minute live Q/A, and ask these editors your burning questions!


[Full Session] Genomics of Cancer I
05:00pm - 06:25pm Eastern - August 18, 2020
Nadine A. Defranoux, PhD, Co-Chair, Parker Institute for Cancer Immunotherapy; Priti Hegde, PhD, Co-Chair, Foundation Medicine
Track: Genomics of Cancer I

Tuesday
Pan-Cancer Analysis of Allele-Specific HLA-I Loss Suggests Widespread Occurrence across a Diverse Range of Tumor Types
05:05pm - 05:30pm Eastern - August 18, 2020
Priti Hegde, PhD, Foundation Medicine
Track: Genomics of Cancer I

Tuesday
Tumor Genomics and Selective Response to Cancer Immunotherapy
05:30pm - 05:55pm Eastern - August 18, 2020
Eliezer M. Van Allen, MD, Dana-Farber Cancer Institute
Track: Genomics of Cancer I

Tuesday
Short Talk: Splice Variants as Neoantigens for Cancer Immunotherapy
06:10pm - 06:25pm Eastern - August 18, 2020
Gloria Bora Kim, PhD, University of Pennsylvania
Track: Genomics of Cancer I