Keyword Filter

Arginase Is an Immunosuppressive Enzyme [POSTER PRESENTATION]

Recorded during the Keystone Symposia meeting:

Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology

Mar 19 - Mar 23, 2017 | Whistler, British Columbia, Canada


Βeta-Alethine, an Immunostimulatory Drug that Synergizes with Anti-PD1 Therapy [POSTER PRESENTATION]

Recorded during the Keystone Symposia meeting:



Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology



Mar 19 - Mar 23, 2017 | Whistler, British Columbia, Canada


Humanized Mouse: A Model for Understanding Tumor-Immune System Interactions [SHORT TALK]

Recorded during the Keystone Symposia meeting:



Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology



Mar 19 - Mar 23, 2017 | Whistler, British Columbia, Canada


NHP Model Recapitulates B Cell-Directed CAR T Cell-Mediated CRS and Neurologic Toxicity [SHORT TALK]

Recorded during the Keystone Symposia meeting:



Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology



Mar 19 - Mar 23, 2017 | Whistler, British Columbia, Canada


Clinical HIV Research

Recorded on March 26, 2017

Pre Meeting Workshop

HIV VACCINES

March 26 - March 30, 2017

Steamboat Springs, Colorado, USA



This Keystone Symposia SciTalk was made possible by a grant from the

d0df3bff33825b37161989b255669eb6.png


The goal of the pre meeting workshop is to provide valuable background on what to expect for the upcoming Keystone Symposia. The intent is to bring participants up to speed on the concepts to be presented at the meeting and enable the them to maximize their experience.




Health Disparities: The Intersection of Science and Race

Forty years ago, the infamous Tuskegee syphilis trials called attention to the disparate treatment of underrepresented (UR) populations in the U.S., prompting a major overhaul of the U.S. public healthcare system. Since 2003, Congress has mandated that the Federal government produce the annual National Healthcare Disparities Report as part of the effort to monitor national progress in this domain.

Keystone Symposia is striving to move the health disparities conversation forward by incorporating discussion into our conferences on cardiovascular and metabolic diseases, immunology, cancer and other diseases that impact populations worldwide.

The focus of this roundtable is on the U.S. and the persistent health disparities that exist among UR communities. In this Keystone Symposia roundtable conversation on “Health Disparities: The Intersection of Science and Race” we will discuss how efforts undertaken by Keystone Symposia’s health disparities working groups on cancer and genetics/genomics may one day contribute to national research efforts on these issues.

The roundtable will examine the intersection of genes, race and disease. Watch this lively panel discussion moderated by Dr. Irelene Ricks and then ask the panelists your questions.

Among other topics, the discussion will focus on:

  • The biology of health disparities
  • The role of epigenetics in health disparities research
  • The public health issues surrounding disparate healthcare access and treatment
  • Priorities, obstacles and controversies facing the field, including lack of UR health care professionals
  • Catalytic research and novel ideas that push the field in the scientific community’s consciousness



Event Hashtag: #VKSdisparities






The views expressed in this ePanel are those of the participants and not necessarily of the participants’ organizations or of Keystone Symposia.







HIV: Antibody Functions Beyond Neutralization

Antibodies that neutralize HIV can potentially provide sterilizing protection against the virus by blocking infection of cells. Meanwhile, there is strong evidence that anti-HIV antibodies can destroy infected cells by binding to HIV envelope on the cell surface and activating a range of effector cells (NK cells, monocytes, macrophages, …) via their Fc receptors. Fc-mediated effector functions likely complement the neutralizing activity of antibodies, and may also play a role in protection by non-neutralizing antibodies. Indeed, in the only HIV vaccine trial that has so far shown efficacy, protection was associated with non-neutralizing antibodies.

Still, many questions persist in this area of HIV research, such as: How to disentangle the effects of neutralization and of various Fc-mediated functions of antibodies? Which of these functions are important for the prevention of HIV infection? What lessons can be drawn from animal models and how well can they be applied to humans? Can non-neutralizing antibodies with Fc-mediated functions contribute to protection? How can such antibodies be elicited by vaccination? Which antibody functions should be assayed? What are the limitations of current assays? What can we learn from ongoing and planned efficacy trials?

Watch this lively panel discussion moderated by Gabriella Scarlatti (Global HIV Vaccine Enterprise), along with expert panelists Ann Hessell (Oregon Health & Science University), Guido Ferrari (Duke University), and Robin Shattock (Imperial College London), as they attempt to answer these questions and more.

This broadcast was pre-recorded during Keystone Symposia’s conference on “HIV Vaccines” in Steamboat Springs, Colorado, USA, March 26-30, 2017.

Please note that there will be no live audience Q&A during the broadcast.


Event Hashtag: #vksHIV17


This virtual event is co-organized with:

GHVE



CRISPR droplet sequencing (CROP-seq)Massive-scale functional screens with single-cell transcriptome readout

Recorded during the Keystone Symposia meeting:

Single Cell Omics

May 26-30, 2017 | Stockholm, Sweden


What are Screencast Videos

A screencast is a digital video recording that captures actions taking place on a computer display. The Keystone Symposia thought leaders presented over the web and provided voice-over narration for their presentation materials.

  • Static and other audio anomalies are present on some videos due to internet traffic at the time of the presentation.
  • Since the talks were given a second time, they may not be identical to those presented in the meeting sessions.
  • To preview the titles and speakers of the scientific presentations videos, click on the "OnDemand Videos" tab on this page. Alternatively, click on this link to view an index.



Don’t fear the zeros: Identifying transcriptional states and cellular populations in sparse single-cell RNA-seq data with Bayesian hierarchical modeling

Recorded during the Keystone Symposia meeting:

Single Cell Omics

May 26-30, 2017 | Stockholm, Sweden


What are Screencast Videos

A screencast is a digital video recording that captures actions taking place on a computer display. The Keystone Symposia thought leaders presented over the web and provided voice-over narration for their presentation materials.

  • Static and other audio anomalies are present on some videos due to internet traffic at the time of the presentation.
  • Since the talks were given a second time, they may not be identical to those presented in the meeting sessions.
  • To preview the titles and speakers of the scientific presentations videos, click on the "OnDemand Videos" tab on this page. Alternatively, click on this link to view an index.


Resolving bifurcation of T helper cell fates at single-cell level

Recorded during the Keystone Symposia meeting:

Single Cell Omics

May 26-30, 2017 | Stockholm, Sweden


What are Screencast Videos

A screencast is a digital video recording that captures actions taking place on a computer display. The Keystone Symposia thought leaders presented over the web and provided voice-over narration for their presentation materials.

  • Static and other audio anomalies are present on some videos due to internet traffic at the time of the presentation.
  • Since the talks were given a second time, they may not be identical to those presented in the meeting sessions.
  • To preview the titles and speakers of the scientific presentations videos, click on the "OnDemand Videos" tab on this page. Alternatively, click on this link to view an index.