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Chewing the Fat: Panel and Discussion about Autophagy and Future Directions of the Autophagy Field

Keystone Symposia ePanel:

Chewing the Fat: Panel and Discussion about Autophagy and Future Directions of the Autophagy Field

This panel discussion occurred during the "Autophagy: Molecular and Physiological Mechanisms" Keystone Symposia conference in Whistler, British Columbia, Canada on June 7, 2016. Eric Baehrecke, Ana Maria Cuervo, Vojo Deretic and Leon Murphy met to discuss their interests in autophagy. Topics included some history, current and future areas of research focus, controversies, and speculation about the future directions of the autophagy field.


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About Keystone Symposia:

Keystone Symposia is a 501(c)(3) nonprofit organization founded in 1972 that convenes 50-60 open, international scientific research conferences each year across the full range of the life sciences – from cardiovascular disease to immunology to neurobiology. The conferences accelerate life science discovery by bringing together and fostering collaboration among the world’s leading and next generation of research scientists.

Website: www.keystonesymposia.org




Autophagy: Controversies, Challenges & Opportunities

Keystone Symposia ePanel:

Autophagy: Controversies, Challenges & Opportunities


Recorded during Keystone Symposia meeting: Autophagy [E615]

Date: June 19 - 24, 2015

Location: Beaver Run Resort, Breckenridge, CO


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About Keystone Symposia:

Keystone Symposia is a 501(c)(3) nonprofit organization founded in 1972 that convenes 50-60 open, international scientific research conferences each year across the full range of the life sciences – from cardiovascular disease to immunology to neurobiology. The conferences accelerate life science discovery by bringing together and fostering collaboration among the world’s leading and next generation of research scientists.

Website: www.keystonesymposia.org




Determinants of viral control following ART-interruption in SIV-infected macaques

Keystone Symposia SciTalks:

Determinants of viral control following ART-interruption in SIV-infected macaques


Recorded: March 20 - 24, 2016

Keystone Symposia meeting: HIV Vaccines [X8]

Location: Resort at Squaw Creek, Olympic Valley, CA


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About Keystone Symposia:

Keystone Symposia is a 501(c)(3) nonprofit organization founded in 1972 that convenes 50-60 open, international scientific research conferences each year across the full range of the life sciences – from cardiovascular disease to immunology to neurobiology. The conferences accelerate life science discovery by bringing together and fostering collaboration among the world’s leading and next generation of research scientists.

Website: www.keystonesymposia.org




Immunogen Design

Recorded on March 26, 2017


Pre Meeting Workshop

HIV VACCINES

March 26 - March 30, 2017

Steamboat Springs, Colorado, USA


This Keystone Symposia SciTalk was made possible by a grant from the


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The goal of the pre meeting workshop is to provide valuable background on what to expect for the upcoming Keystone Symposia. The intent is to bring participants up to speed on the concepts to be presented at the meeting and enable the them to maximize their experience.




Broadly Neutralizing Antibodies to HIV: History, Challenges and Hopes

Recorded on March 26, 2017


Pre Meeting Workshop

HIV VACCINES

March 26 - March 30, 2017

Steamboat Springs, Colorado, USA


This Keystone Symposia SciTalk was made possible by a grant from the

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The goal of the pre meeting workshop is to provide valuable background on what to expect for the upcoming Keystone Symposia. The intent is to bring participants up to speed on the concepts to be presented at the meeting and enable the them to maximize their experience.

Recorded on March 26, 2017






At the edge of survival: Genetic associations for cell death in pemphigus foliaceus


Biotechnology applied to therapeutic and diagnostic innovation for cancer in Brazil

Cancer is a major cause of mortality worldwide, killing about 9 million people each year. Ovarian cancer is one of the ten most common cancers in women, considered the most fatal among gynecological tumors; and prostate cancer one of the most frequent and fatal in men. The detection of these tumor types currently has important limitations, hindering the efficiency of treatment and consequently patient’s survival. Specific molecules produced by tumors could be used as biomarkers and are considered good targets for diagnosis. Thus, the use of aptamers represents an important tool that could be applied to improve specificity in tumor diagnosis and personalized therapy. Aptamers are small, single-stranded synthetic oligonucleotides, capable of binding with high specificity to a molecular target, and are promising due to their unique pharmacokinetic properties: they are not immunogenic and are susceptible to chemical modifications and bioconjugations to nanoparticles, imaging agents and therapeutic drugs. In this way, the application of this technology could generate diagnoses for rapid and preventive detection that improve the life expectancy of patients with ovarian and prostate tumors. The main goal of this project is the creation of a tumor-specific diagnostic method, which differentiates benign, metastatic, and non-metastatic tumors, for application in liquid biopsies and magnetic resonance for ovarian and prostate cancer. In this purpose, the Cell-Selex method was applied for the selection of specific aptamers for each tumor type considering its condition as: benign, metastatic, and non-metastatic. Although the use of this methodology is being explored in several diseases, its application in ovarian and prostate tumors has an innovative character and will contribute to the technological development of public health in Brazil.

Development of CAR-T Cell Therapies for Leukemia


Tumor neoantigens identificsation and formulation testing for therapeutic vaccines development to treat cancer


The Genome Editing Revolution - Translating Genome Editing Technologies into Human Therapies

Keystone Symposia Live Panel:
The Genome Editing Revolution: Translating Genome Editing Technologies into Human Therapies


Recent advances in genome editing nucleases have led to their broader application in biomedical research and dramatically accelerated efforts to develop therapeutics based on this technology. In this dynamic, interactive panel event, experts in genome editing and gene therapy from academia and industry will discuss the following topics and others relevant to clinical translation of the technology:

  • What are the most important recent basic science and technological advances and biggest impacts in the field of genome editing that will substantially advance the prospects of gene-based therapy?
  • How can the experiences of the gene therapy field inform the development of genome editing therapeutics?
  • What are the risks and biggest obstacles that must be minimized and overcome to successfully translate genome editing into human therapeutics?
  • Which diseases are the most promising candidates to benefit from genome editing therapies?
  • What impact, if any, has the CRISPR IP dispute had on developing gene-based therapeutics?


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Copyright Keystone Symposia, 2017. All rights reserved.

About Keystone Symposia:
Keystone Symposia is a 501(c)(3) nonprofit organization founded in 1972 that convenes 50-60 open, international scientific research conferences each year across the full range of the life sciences – from cardiovascular disease to immunology to neurobiology. The conferences accelerate life science discovery by bringing together and fostering collaboration among the world’s leading and next generation of research scientists.

Website: www.keystonesymposia.org