Bacterial Flora Associated With Prostate Cancer Patients in Lagos, Nigeria Olayemi Oluseun Ayepola1*,Emeka E.J. Iweala1, Chidiebere Ndukwe Ogo2, Stephen Odunayo Ikuerowo3,Bamidele Mutiu4, Olumuyiwa Louis Ojongbede4 1Department of Biological Sciences, Covenant University, Ota, Ogun State, Nigeria; 2Department of Urology, Federal Medical Centre, Abeokuta, Ogun State, Nigeria; 3Department of Surgery, Urology Division, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria; 4Department of Microbiology, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria *Corresponding author
Epidemiological studies have shown signiﬁcant associations between infection, inﬂammation and prostatic carcinoma. Bacterial species postulated to contribute to prostate cancer include Chlamydia trachomatis, Trichomonas vaginalis, Escherichia coli, Pseudomonas spp., Proteus mirabilis, Klebsiella spp. and Serratia spp. In this study we investigated the bacterial flora especially those previously reported as being capable of establishing prostatic infections present in the urine of prostate cancer patients. We also investigated the antibiotic susceptibility profile of the isolates. Mid-stream urine were collected from 36 patients and cultured on appropriate media and bacterial isolates were identified using established microbiological techniques. The results showed the presence of Escherichia coli (45%), Pseudomonas aeruginosa (17%), Klebsiella oxytoca (24%), Proteus mirabilis (7%) and Staphylococcus aureus (7%).The results of the antibiotic susceptibility testing of the isolates showed 100% susceptibility to fluoroquinolone and 79% susceptibility to amikacin. However we observed high level resistance to other antibiotics such as ceftazidime (100%), sulphamethoxazole (100%), augmentin (100%), ceftriaxone (97%) and erythromycin (88%). The results of this study have shown the presence of previously documented bacteria which have been associated with inflammation. This suggests that there might be a role of these colonizing bacteria in the development of prostate cancer.
Sfanos KS, Isaacs WB, De Marzo AM (2013) Infections and inflammation in prostate cancer. American journal of clinical and experimental urology 1(1): 3-11.
Shrestha E et al. (2018) Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer Journal of Urology 199(1): 161-171.
Funding Source Prostate cancer transatlantic consortium (CaPTC).
Credits: None available.
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