Quantitative assessment of the anti-inflammatory effects of progranulin on human and rodent microglia
Amanda Placone1, Joseph Corey Evans1, Andreas Zembrzycki1, Paul Wren2 & Min Li2 1Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037; 2GlaxoSmithKline, Neuroscience Discovery, Collegeville, PA 19426
Frontotemporal dementia (FTD) is a presenile dementia caused by degeneration of the frontal and temporal lobes, with significant heterogeneity in disease onset and symptomatology including progressive decline in behavior, language and in some cases motor function . One of the earliest histopathological features of FTD is a large degree of micro- and astrogliosis . Heterozygous loss of the pleiotropic protein progranulin (PGRN) is one of the most common genetic causes of FTD . We have conducted quantitative cellular studies to demonstrate that PGRN regulates pro-inflammatory cytokine secretion in both human and rodent microglia. These data provide insights into potential future studies to further understand the role of progranulin in neuroinflammation related to FTD and potentially other neurodegenerative diseases.
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