Regulation of Selective Autophagy Anne Simonsen Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Regulation of mitochondrial mass and elimination of dysfunctional or superfluous mitochondria is essential for maintenance of healthy cellular homeostasis. Failure of the quality control system that recognizes damaged mitochondria is associated with aberrant mitochondrial accumulation, oxidative stress, protein aggregation and apoptosis. Using an immunoprecipitation approach we identified two mitochondrial matrix proteins as binding partners of the large scaffolding protein ALFY and the autophagy receptor p62, both found to be involved in selective autophagy of protein aggregates. We show that these matrix proteins relocalize to the surface of depolarized mitochondria and are important for Parkin-dependent mitophagy. Their depletion in zebrafish leads to parkinsonism, suggesting they function as eat-me signals for Parkin-dependent mitophagy.
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