FUNDC1-mediated mitophagy regulates mitochondrial quality and quality
Lei Liu1, Yanjun Li1, Yushan Zhu2 and Quan Chen1, 2 * 1 The State Key Laboratory of Membrane Biology, Chinese Academy of Sciences, Beijing 100101, China. 2Colleage of Life Science, Nankai University, China. *E-mail: email@example.com
Mitochondria control both the life and death of a cell. Mitophagy, a selective process that removes damaged or unwanted mitochondria, is critical for the maintenance of mitochondrial quality and quantity. Previously, we have revealed that FUNDC1, a mitochondrial outer-membrane protein, functions as a mitophagy receptor to mediate hypoxia-induced mitophagy. FUNDC1 harbors an LC-3 -interacting region (LIR) and interacts with LC-3 to mediate mitophagy both in cultured cell systems and in (patho-)physiological settings. Our recent results showed that FUNDC1 is involved in the cold induced mitophagy and contributes to adaptive thermogenesis. We suggest a new mechanism of how mitophagy is coupled with mitochondrial biogenesis, thus governing the overall mitochondrial abundance, quality and turnover.
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