Expression of HBeAg, anti-HCV and HIVP24Ag-Ab in relationship with the evidence of anti-viral immune response in newly infected Mycobacterium tuberculosis patients


Identification: Olaniyan-Mathew


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Expression of HBeAg, anti-HCV and HIVP24Ag-Ab in relationship with the evidence of anti-viral immune response in newly infected Mycobacterium tuberculosis patients
Mathew Folaranmi OLANIYAN1**, Tolulope Busayo OJEDIRAN1 and Shedrack Gbenga OLAYINKA2

1. Department of Medical Laboratory Science, Edo University, Iyamho- Nigeria; 2.Department of Medical Laboratory Science, Achievers University, Owo- Nigeria
Email: olaniyanmat@yahoo.com  GSM : +2348052248019
**1 Principal and Corresponding Author 
 
Abstract
Study Background: Mycobacterium tuberculosis coinfection with virus may generate active viral process that may bring about inflammation and liver damage due to anti-viral host immune response especially in hepatotropic viral infections. Aim and Objective: This work therefore sought to investigate the expression of HBeAg, anti-HCV and HIVP24Ag-Ab in relationship with the evidence of anti-viral immune response in newly infected Mycobacterium tuberculosis patients. Materials and Methods: This work was carried out among forty one (41: Female – 17; Male-24) newly infected M. tuberculosis patients aged 46 – 64 years ; those who expressed viral immuno serological markers were studied as test subjects while  those who were not infected with HIV, HCV and HBV were studied as Control. All subjects were negative to Giemsa thick blood film test for identification of Plasmodium. TNFα, HBeAg, anti-HCV and HIVP24Ag-Ab were determined by ELISA while ALT was determined by spectrophotometry. M. tuberculosis was detected using Ziehl Neelsen staining. Results: The frequency of immune serological markers in M. tuberculosis patients  include 17%(7)HBeAg; 9.8%(4)Anti-HCV; 2.4%(1)HIVP24Ag-Ab and 70.7%(29)Mycobacterium tuberculosis patients not infected with HIV, HCV and HBV. Plasma TNFα and ALT were significantly higher in patients with Mycobacterium tuberculosis + HBeAg and Mycobacterium tuberculosis  + Anti-HCV compared with Mycobacterium tuberculosis patients not infected with HIV, HCV and HBV(p<0.05). There was a significant increase in plasma TNFα in patients with Mycobacterium tuberculosis + HIVP24Ag-Ab compared with the Mycobacterium tuberculosis patients not infected with HIV, HCV and HBV(p<0.05).There was a significant increase in TNFα and ALT in patients with M. tuberculosis + HBeAg compared with the results obtained patients with Mycobacterium tuberculosis + HIVP24Ag-Ab(p<0.05). There was a significant increase in plasma ALT in patients with Mycobacterium tuberculosis + HBeAg compared with patients Mycobacterium tuberculosis + Anti-HCV and patients with Mycobacterium tuberculosis patients + Anti-HCV compared Mycobacterium tuberculosis + HIVP24Ag-Ab(p<0.05). Conclusion: This work revealed antiviral immune response in Mycobacterium tuberculosis patients  as manifested by increase in plasma TNFα and ALT in relationship with the immune serological markers in Mycobacterium tuberculosis patients that include 17%(7)HBeAg; 9.8%(4)Anti-HCV; 2.4%(1)HIVP24Ag-Ab; and 70.7%(29)Mycobacterium tuberculosis patients not infected with HIV, HCV and HBV which can be prevented in Mycobacterium tuberculosis patients through adequate viral evaluation and vaccination against HBV and HCV.
Keywords: HBeAg,  anti-HCV, HIVP24Ag-Ab, anti-viral immune response, ALT, TNFα, Mycobacterium tuberculosis patients    

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