Bret H. Goodpaster PhD

Translational Research Institute for Metabolism and Diabetes

Bret Goodpaster, Ph.D. is a Senior Investigator and Scientific Director at the AdventHealth Translational Research Institute (TRI). Dr. Goodpaster’s primary research is in the pathophysiology of human obesity, insulin resistance, and diabetes, and to help decipher biological mechanisms underlying the health benefits of exercise that can be translated back into new and better treatments for these conditions. He has received a number of awards and honors for his work, including the Nathan Shock Award from the National Institute of Aging in 2008, awarded to the most outstanding investigator in the US in the field of Aging, for his work investigating the role of muscle fat infiltration in aging and muscle quality. He is particularly well known for “the athlete’s paradox” which has shifted the paradigm in Type 2 diabetes research to investigate, how and why does fat accumulation in muscle cause insulin resistance in some subjects but not others?

Dr. Goodpaster has published over 250 peer-reviewed papers, review articles and book chapters, and his papers have received more than 26,000 citations (h-index 81). He has served on Editorial Boards for Diabetes, the American Journal of Physiology, the Journals of Gerontology, and is currently an Associate Editor for Diabetologia. He has also served on several NIH grant review panels as well as the American Diabetes Association. Dr. Goodpaster obtained a B.S. in Biology from Purdue, and after completing a Pre-doctoral Fellowship at Maastricht University in the Netherlands, received his Ph.D. in Human Bioenergetics from Ball State University in 1995. Prior to coming to the AdventHealth TRI, he was Professor of Medicine and UPMC Chair for Diabetes and Metabolism Research at the University of Pittsburgh.