Immunoprofiling of non-tuberculous mycobacterial infection patients reveal global T cell dysfunction and individuals at risk
The human immune system is a hugely complex network of cell types relentlessly communicating on host health through direct recognition and secreted compounds. We have recently found that listening to this immune cell “chatter” through phenotyping or molecular typing can inform pathology in rapid time using high-dimensional analysis and predictive analytics. We are currently developing highly sensitive and specific immune signatures for diagnostics, prognostics and identifying individuals at high risk of disease. In this talk, I will describe the work we have achieved from non-tuberculosis mycobacterium patients.
Professor John Miles is Principal Research Fellow of Molecular Immunology at the Australian Institute of Tropical Health and Medicine, James Cook University, Australia. He is co-director for the Centre for Tropical Bioinformatics and Molecular Biology and theme leader for the Centre for Molecular Therapeutics at James Cook University. Professor Miles is an expert in human immune system monitoring and modulation.